The Hardest Binding of Isaac Bosses
A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest. We combined votes from 4 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.
Vote Now27 Enemies
30 Votes
4 Voters
All Votes
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Rating
1.Ultra Greedier
1100Rating0
Spread1.The Visage
1100Rating0
Spread1.Tuff Twins
1100Rating0
Spread4.Mega Satan
293Rating1.8
Spread5.Delirium
192Rating0
Spread6.Hornfel
186Rating0
Spread7.Ultra Greed
179Rating0
Spread8.The Heretic
175Rating0
Spread9.Mother
171Rating0
Spread9.Reap Creep
171Rating0
Spread11.Hush
164Rating0
Spread12.Singe
157Rating0
Spread12.Dogma
157Rating0
Spread14.??? (Boss)
150Rating0
Spread14.The Siren
150Rating0
Spread16.Satan
143Rating0
Spread16.The Pile
143Rating0
Spread18.Isaac (Boss)
129Rating0
Spread18.Great Gideon
129Rating0
Spread20.Mom's Heart
227Rating10.9
Spread21.The Horny Boys
125Rating0
Spread22.Mom
121Rating0
Spread23.The Shell
114Rating0
Spread24.The Lamb
213Rating3.3
Spread25.It Lives
17Rating0
Spread26.Clutch
10Rating0
Spread26.The Beast
10Rating0
Spread
