The Hardest Slay the Spire Bosses Tier List

A list of all Slay the Spire bosses, ranked from hardest to easiest. We combined votes from 9 players to create this list. Boss fights are typically the most challenging fights you'll face in Slay the Spire. The hardest bosses have ended numerous runs. All bosses pose a threat, but some are more consistently difficult than others to overcome.