The Hardest Slay the Spire Bosses Tier List

A list of all Slay the Spire bosses, ranked from hardest to easiest. We combined votes from 9 players to create this list. Boss fights are typically the most challenging fights you'll face in Slay the Spire. The hardest bosses have ended numerous runs. All bosses pose a threat, but some are more consistently difficult than others to overcome.

10 Enemies

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98 Votes

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9  Voters

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S

A

B

C

D

F

S Tier

Corrupt Heart

A Tier

The Collector, Time Eater

B Tier

Awakened One, Bronze Automaton

C Tier

The Champ, Slime Boss, Donu and Deca

D Tier

Hexaghost

F Tier

The Guardian

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