The Hardest Slay the Spire Bosses Tier List

A list of all Slay the Spire bosses, ranked from hardest to easiest. We combined votes from 10 players to create this list. Boss fights are typically the most challenging fights you'll face in Slay the Spire. The hardest bosses have ended numerous runs. All bosses pose a threat, but some are more consistently difficult than others to overcome.