The Hardest Slay the Spire Bosses - Hardest Mood Board

A list of all Slay the Spire bosses, ranked from hardest to easiest.

We combined votes from 13 players to create this list. Boss fights

are typically the most challenging fights you'll face in Slay the

Spire. The hardest bosses have ended numerous runs. All bosses pose

a threat, but some are more consistently difficult than others to

overcome.