The Best Angel Room Items

A list of all angel room items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 81 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

Rankings updated August 22, 2025.

66 Items

1K Votes

81 Voters

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1.Sacred Heart
1.Sacred Heart
Angel Room
Passive
Ultra Secret Room
Quality 4
64
100
Rating
0.3
Spread
64
100
Rating
0.3
Spread

2.Trisagion
2.Trisagion
Angel Room
Quality 3
Passive
7
89
Rating
3.1
Spread
7
89
Rating
3.1
Spread

3.Holy Light
3.Holy Light
Angel Room
Quality 3
Passive
Treasure Room
8
85
Rating
2.2
Spread
8
85
Rating
2.2
Spread

4.Book of Virtues
4.Book of Virtues
Angel Room
Quality 3
Activated
Library
10
84
Rating
3.2
Spread
10
84
Rating
3.2
Spread

5.Sacred Orb
5.Sacred Orb
Angel Room
Passive
Secret Room
Quality 4
65
83
Rating
0.4
Spread
65
83
Rating
0.4
Spread

6.The Halo
6.The Halo
Quality 2
Angel Room
Passive
Treasure Room
Boss
7
81
Rating
2.6
Spread
7
81
Rating
2.6
Spread

7.Blood of the Martyr
7.Blood of the Martyr
Angel Room
Quality 3
Passive
Treasure Room
Wooden Chest
9
80
Rating
2.7
Spread
9
80
Rating
2.7
Spread

8.Godhead
8.Godhead
Angel Room
Passive
Quality 4
63
78
Rating
0.4
Spread
63
78
Rating
0.4
Spread

9.The Mind
9.The Mind
Angel Room
Quality 3
Passive
Treasure Room
9
78
Rating
2.3
Spread
9
78
Rating
2.3
Spread

10.Holy Grail
10.Holy Grail
Angel Room
Quality 3
Passive
6
77
Rating
6.9
Spread
6
77
Rating
6.9
Spread

11.Eucharist
11.Eucharist
Angel Room
Quality 3
Passive
8
77
Rating
4.1
Spread
8
77
Rating
4.1
Spread

12.Dead Dove
12.Dead Dove
Angel Room
Quality 3
Passive
5
77
Rating
5.9
Spread
5
77
Rating
5.9
Spread

13.The Stairway
13.The Stairway
Angel Room
Quality 3
Passive
9
75
Rating
4.2
Spread
9
75
Rating
4.2
Spread

14.Holy Mantle
14.Holy Mantle
Angel Room
Passive
Treasure Room
Quality 4
61
75
Rating
0.5
Spread
61
75
Rating
0.5
Spread

15.Spirit Sword
15.Spirit Sword
Angel Room
Quality 3
Passive
11
69
Rating
4.4
Spread
11
69
Rating
4.4
Spread

16.Genesis
16.Genesis
Angel Room
Quality 3
Activated
9
68
Rating
2.9
Spread
9
68
Rating
2.9
Spread

17.Book of Revelations
17.Book of Revelations
Angel Room
Quality 3
Treasure Room
Activated
Library
8
67
Rating
5
Spread
8
67
Rating
5
Spread

18.The Soul
18.The Soul
Angel Room
Quality 3
Passive
Treasure Room
8
67
Rating
4.4
Spread
8
67
Rating
4.4
Spread

19.Duality
19.Duality
Angel Room
Passive
Quality 1
Devil Room
10
66
Rating
4
Spread
10
66
Rating
4
Spread

20.Eden's Soul
20.Eden's Soul
Angel Room
Quality 3
Activated
9
64
Rating
3.1
Spread
9
64
Rating
3.1
Spread

21.Act of Contrition
21.Act of Contrition
Angel Room
Quality 3
Passive
10
61
Rating
2.7
Spread
10
61
Rating
2.7
Spread

22.Habit
22.Habit
Quality 2
Angel Room
Passive
Shop
10
61
Rating
3.4
Spread
10
61
Rating
3.4
Spread

23.Immaculate Heart
23.Immaculate Heart
Angel Room
Quality 3
Passive
Ultra Secret Room
11
61
Rating
3.5
Spread
11
61
Rating
3.5
Spread

24.Paschal Candle
24.Paschal Candle
Angel Room
Quality 3
Passive
9
58
Rating
4.6
Spread
9
58
Rating
4.6
Spread

25.Angelic Prism
25.Angelic Prism
Angel Room
Quality 3
Passive
9
55
Rating
4.1
Spread
9
55
Rating
4.1
Spread

26.Holy Water
26.Holy Water
Angel Room
Quality 3
Passive
Treasure Room
6
55
Rating
4.1
Spread
6
55
Rating
4.1
Spread

27.Salvation
27.Salvation
Angel Room
Quality 3
Passive
8
52
Rating
5.3
Spread
8
52
Rating
5.3
Spread

28.Rosary
28.Rosary
Quality 2
Angel Room
Passive
Ultra Secret Room
Treasure Room
10
49
Rating
3.4
Spread
10
49
Rating
3.4
Spread

29.7 Seals
29.7 Seals
Quality 2
Angel Room
Passive
Devil Room
13
48
Rating
3.4
Spread
13
48
Rating
3.4
Spread

30.The Relic
30.The Relic
Angel Room
Quality 3
Passive
Treasure Room
7
48
Rating
6.2
Spread
7
48
Rating
6.2
Spread

31.Seraphim
31.Seraphim
Angel Room
Quality 3
Passive
Baby Shop
Treasure Room
11
47
Rating
3.3
Spread
11
47
Rating
3.3
Spread

32.Censer
32.Censer
Angel Room
Quality 3
Passive
11
47
Rating
4
Spread
11
47
Rating
4
Spread

33.Purity
33.Purity
Angel Room
Quality 3
Passive
Treasure Room
9
47
Rating
3.7
Spread
9
47
Rating
3.7
Spread

34.Trinity Shield
34.Trinity Shield
Quality 2
Angel Room
Passive
9
45
Rating
4.9
Spread
9
45
Rating
4.9
Spread

35.Glyph of Balance
35.Glyph of Balance
Quality 2
Angel Room
Passive
7
44
Rating
5.5
Spread
7
44
Rating
5.5
Spread

36.Stigmata
36.Stigmata
Quality 2
Angel Room
Passive
Treasure Room
Wooden Chest
8
44
Rating
5.9
Spread
8
44
Rating
5.9
Spread

37.Scapular
37.Scapular
Quality 2
Angel Room
Passive
Treasure Room
9
44
Rating
3.4
Spread
9
44
Rating
3.4
Spread

38.Soul Locket
38.Soul Locket
Angel Room
Passive
Quality 1
7
44
Rating
5.7
Spread
7
44
Rating
5.7
Spread

39.Divine Intervention
39.Divine Intervention
Quality 2
Angel Room
Passive
11
41
Rating
4.1
Spread
11
41
Rating
4.1
Spread

40.Mitre
40.Mitre
Angel Room
Quality 3
Passive
Treasure Room
10
41
Rating
3.5
Spread
10
41
Rating
3.5
Spread

41.Crown of Light
41.Crown of Light
Angel Room
Passive
Quality 4
66
40
Rating
0.6
Spread
66
40
Rating
0.6
Spread

42.The Body
42.The Body
Angel Room
Quality 3
Passive
Ultra Secret Room
Treasure Room
9
40
Rating
4.4
Spread
9
40
Rating
4.4
Spread

43.Star of Bethlehem
43.Star of Bethlehem
Angel Room
Quality 3
Passive
6
40
Rating
8.5
Spread
6
40
Rating
8.5
Spread

44.Immaculate Conception
44.Immaculate Conception
Angel Room
Passive
Quality 1
9
37
Rating
4.4
Spread
9
37
Rating
4.4
Spread

45.The Bible
45.The Bible
Angel Room
Quality 1
Activated
Library
Shop
5
37
Rating
10.6
Spread
5
37
Rating
10.6
Spread

46.Revelation
46.Revelation
Angel Room
Passive
Quality 4
61
36
Rating
0.6
Spread
61
36
Rating
0.6
Spread

47.Prayer Card
47.Prayer Card
Angel Room
Quality 3
Treasure Room
Activated
8
36
Rating
5.3
Spread
8
36
Rating
5.3
Spread

48.The Wafer
48.The Wafer
Angel Room
Passive
Treasure Room
Quality 4
65
35
Rating
0.5
Spread
65
35
Rating
0.5
Spread

49.Circle of Protection
49.Circle of Protection
Quality 2
Angel Room
Passive
9
34
Rating
5
Spread
9
34
Rating
5
Spread

50.Hallowed Ground
50.Hallowed Ground
Angel Room
Passive
Quality 1
Treasure Room
9
33
Rating
3.7
Spread
9
33
Rating
3.7
Spread

51.Urn of Souls
51.Urn of Souls
Angel Room
Quality 3
Activated
8
33
Rating
5.7
Spread
8
33
Rating
5.7
Spread

52.Spear of Destiny
52.Spear of Destiny
Quality 2
Angel Room
Passive
11
33
Rating
3.5
Spread
11
33
Rating
3.5
Spread

53.Purgatory
53.Purgatory
Quality 2
Angel Room
Passive
Devil Room
9
30
Rating
4
Spread
9
30
Rating
4
Spread

54.Sworn Protector
54.Sworn Protector
Angel Room
Quality 3
Passive
Baby Shop
10
30
Rating
3.6
Spread
10
30
Rating
3.6
Spread

55.Guardian Angel
55.Guardian Angel
Quality 2
Angel Room
Passive
Baby Shop
8
28
Rating
5.3
Spread
8
28
Rating
5.3
Spread

56.Monstrance
56.Monstrance
Quality 2
Angel Room
Passive
7
26
Rating
3.2
Spread
7
26
Rating
3.2
Spread

57.Lil Delirium
57.Lil Delirium
Quality 2
Angel Room
Passive
Baby Shop
Devil Room
9
25
Rating
3
Spread
9
25
Rating
3
Spread

58.Jesus Juice
58.Jesus Juice
Quality 2
Angel Room
Passive
Boss
8
25
Rating
4.3
Spread
8
25
Rating
4.3
Spread

59.Breath of Life
59.Breath of Life
Angel Room
Quality 1
Activated
8
25
Rating
4.1
Spread
8
25
Rating
4.1
Spread

60.Jar of Wisps
60.Jar of Wisps
Quality 2
Angel Room
Activated
8
22
Rating
4.2
Spread
8
22
Rating
4.2
Spread

61.Celtic Cross
61.Celtic Cross
Angel Room
Passive
Quality 1
Treasure Room
9
21
Rating
3.2
Spread
9
21
Rating
3.2
Spread

62.Lazarus' Rags
62.Lazarus' Rags
Angel Room
Passive
Quality 1
Treasure Room
9
13
Rating
3.8
Spread
9
13
Rating
3.8
Spread

63.Void
63.Void
Angel Room
Quality 4
Activated
Devil Room
59
12
Rating
0.5
Spread
59
12
Rating
0.5
Spread

64.Vade Retro
64.Vade Retro
Quality 2
Angel Room
Activated
8
7
Rating
2.8
Spread
8
7
Rating
2.8
Spread

65.Dead Sea Scrolls
65.Dead Sea Scrolls
Angel Room
Quality 1
Treasure Room
Activated
7
6
Rating
0.9
Spread
7
6
Rating
0.9
Spread

66.Delirious
66.Delirious
Angel Room
Quality 1
Activated
9
0
Rating
1
Spread
9
0
Rating
1
Spread