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The Best Devil Room Items Ranked List

95 Items2K Votes102 Voters
Updated November 20, 2025
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A list of all devil room items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 102 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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All 95 Devil Room Items Ranked, Best to Worst | The Binding of Isaac | Unduel