The Hardest Chapter 1 Bosses - Hardest Rankings

17 Enemies

85 Votes

5 Voters

Updated August 27, 2025

A list of all bosses from chapter 1 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 1 includes the Basement, the Cellar, and the Burning Basement.

This list is based on the latest version of The Binding of Isaac: Repentance.

Sort by

Filter by

Group by

All 17 Chapter 1 Bosses Ranked, Hardest to Easiest | The Binding of Isaac | Unduel