The Best Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Red Key, Glitched Crown, Apple!

A Tier

Spoon Bender, Technology, More Options, SMB Super Fan, Goat Head, Eternal D6, Mucormycosis, Jacob's Ladder, Host Hat, Binky, Book of Shadows, Mama Mega!, C Section, Fruit Cake, Rock Bottom, Diplopia, Athame, Car Battery, A Lump of Coal, Black Candle, Bag of Crafting, Holy Light, Mutant Spider, Twisted Pair, Technology Zero, Tough Love, 8 Inch Nails, Eden's Blessing, Sacred Orb, Sharp Plug, Ghost Pepper, Trisagion, Birthright, Glass Eye, Ceremonial Robes, Chaos, The D6, Mr. Dolly, Mom's Pearls, Book of Virtues, R Key, Placenta, The Halo, Godhead, White Pony, Sinus Infection, Spindown Dice, Mom's Knife, Cat-O-Nine-Tails, Technology 2, Growth Hormones, Head of the Keeper, The Small Rock, Explosivo, Holy Mantle, Blood of the Martyr, Euthanasia, Shoop Da Whoop!, The Mind, Fire Mind, Lemegeton, Tooth Picks, Holy Grail, PJs, D20, Eucharist, The Parasite, Mystery Gift, Little Horn (Item), Yum Heart, Playdough Cookie, The Sad Onion, Champion Belt, Rubber Cement, Lil Dumpy, Humbleing Bundle, A Dollar, Wire Coat Hanger, Red Stew, Spirit Sword, Blank Card, Sausage, Tech X, Lodestone, Latch Key, Adrenaline, The Stairway, Dead Dove, Monstro's Lung, Tractor Beam, D Infinity, The Mark, Dogma (Item), Pupula Duplex, Dark Arts, Abaddon, Mom's Perfume, The Intruder, The Pact, Dead Eye, Fate, Dark Matter, Book of Revelations, Blood Bag, Toxic Shock, Rotten Baby, Pluto

B Tier

Camo Undies, Crooked Penny, Eve's Mascara, The Inner Eye, Saturnus, Gnawed Leaf, Serpent's Kiss, Ocular Rift, Divorce Papers, Glitter Bombs, Mom's Contacts, Proptosis, Gello, Scorpio, The Soul, Box of Friends, Blue Map, Treasure Map, Tarot Cloth, Tropicamide, Paschal Candle, Lost Contact, Genesis, Sulfur, Brittle Bones, Almond Milk, Eden's Soul, Death's Touch, YO LISTEN!, Mr. ME!, Transcendence, The Battery, Immaculate Heart, Mysterious Liquid, Duality, Big Fan, MEAT!, Dry Baby, Wooden Nickel, Mega Bean, Habit, Lusty Blood, Contract From Below, The Virus, BFFS!, Rune Bag, Guppy's Eye, Bozo, My Reflection, Leech, Neptunus, 9 Volt, Spider Mod, Magic Skin, Bot Fly, Black Hole, Act of Contrition, Cricket's Body, Bob's Curse, Steam Sale, Eye of Belial, Guppy's Collar, Card Reading, Mom's Key, Echo Chamber, 4.5 Volt, Worm Friend, Eye of the Occult, Aquarius, Angelic Prism, Brimstone, The Candle, Bobby-Bomb, Odd Mushroom (Large), Sulfuric Acid, Rosary, Pop!, Forget Me Now, Succubus, Keeper's Box, Cain's Other Eye, Varicose Veins, Cancer, Pyro, Lil Monstro, Soy Milk, Lachryphagy, Backstabber, Knockout Drops, Chocolate Milk, Contagion, Lil Abaddon, Incubus, The Ludovico Technique, Ventricle Razor, Member Card, Mom's Ring, Psy Fly, Holy Water, Cricket's Head, Suplex!, Bird's Eye, Tooth and Nail, Lead Pencil, Salvation, Montezuma's Revenge, Blanket, Libra, Metal Plate, Gimpy, Whore of Babylon, Capricorn, The Body, Maw of the Void, Mr. Mega, Money = Power, Infamy, Cube of Meat, Roid Rage, PHD, Papa Fly, Bomber Boy, Polydactyly, Lil Portal, Voodoo Head, Stem Cells, Lucky Foot, Crown of Light, Mitre, My Shadow, Deck of Cards, Magic Scab, Magic Mushroom, Virgo, Sumptorium, Spirit of the Night, Alabaster Box, Pentagram, Tech.5, Black Lotus, Astral Projection, Deep Pockets, Revelation, There's Options, Pyromaniac, Fanny Pack, Censer, Luna, Dead Cat, Hive Mind, Damocles, Schoolbag, Terra, Moving Box, Mom's Eye, Empty Vessel, D7, Guppy's Tail, X-Ray Vision, The Wafer, Dad's Key, Sissy Longlegs, 7 Seals, Vanishing Twin, Stigmata, Fast Bombs, Dad's Ring, The Peeper, Tiny Planet, Everything Jar, Stop Watch, Binge Eater, Sticky Bombs, Dark Bum, Compound Fracture, Mega Mush, Night Light, Seraphim, The Common Cold, Torn Photo, Boom!, We Need to Go Deeper!, Teleport 2.0, A Pony, Flat Stone, The Relic, Jaw Bone, Daddy Longlegs, Dead Tooth, Lil Brimstone, Key Piece 1, Potato Peeler, Mystery Sack, Book of the Dead, Smelter, Sacrificial Dagger

C Tier

Marbles, Harlequin Baby, Lunch, Sad Bombs, The Book of Belial, Guillotine, Keeper's Sack, Options?, Raw Liver, Judas' Shadow, D1, Caffeine Pill, Jumper Cables, Guppy's Head, Crystal Ball, Purity, Box of Spiders, Scapular, Soul Locket, Pisces, Match Book, Blue Cap, Immaculate Conception, 3 Dollar Bill, Spirit Shackles, A Bar of Soap, Guppy's Paw, Lil Loki, Synthoil, The Polaroid, Larynx, Odd Mushroom (Thin), Divine Intervention, Halo of Flies, Mom's Lipstick, Analog Stick, Scatter Bombs, Sacrificial Altar, Orphan Socks, Crack the Sky, Flip, Sack of Pennies, Bogo Bombs, Eye Drops, Marrow, Star of Bethlehem, Golden Razor, Cambion Conception, IV Bag, Kidney Stone, Restock, Brother Bobby, Starter Deck, Loki's Horns, The Bible, Sharp Straw, Giant Cell, Dead Bird, Plum Flute, Glyph of Balance, Spear of Destiny, Freezer Baby, Isaac's Tears, Multidimensional Baby, Little Steven, Skeleton Key, Cone Head, Finger!, Magic 8 Ball, Magic Fingers, Consolation Prize, Head of Krampus, Little C.H.A.D., Hallowed Ground, Trinity Shield, Glowing Hourglass, My Little Unicorn, Parasitoid, Cube Baby, Dog Tooth, Coupon, Prayer Card, Sworn Protector, Gemini (Item), 20/20, Eye Sore, Lord of the Pit, Rainbow Baby, Pandora's Box, Bloody Lust, Screw, The Nail, Experimental Treatment, Speed Ball, Mars, Squeezy, BBF, Maggy's Bow, Mom's Purse, Infestation 2, Purgatory, Super Bandage, Butt Bombs, False PHD, Mini Mush, The Mulligan, Sack Head, Broken Modem, Book of Secrets, Sol, Stapler, Monstrance, Breakfast, Ouija Board, Azazel's Rage, Decap Attack, Stye, Cracked Orb, Guppy's Hair Ball, Pointy Rib, Polyphemus, Uranus, Greed's Gullet, Spiderbaby, Glaucoma, Chemical Peel, Ghost Bombs, Teleport!, Belly Jelly, How to Jump, Redemption, Haemolacria, Urn of Souls, The Belt, Isaac's Tomb, Circle of Protection, Dead Onion, Blood Clot, Midas' Touch, Candy Heart, Iron Bar, Blood Rights, Evil Charm, Guardian Angel, Continuum, Quints, Magneto, Monstro's Tooth, The Compass, Jesus Juice, Box, No. 2, Doctor's Remote, Evil Eye, Safety Pin, Jupiter, Bloody Gust, 1up!, Charm of the Vampire, Stitches, Lemon Mishap, Best Bud, Wooden Spoon, 120 Volt, Bloodshot Eye, ???'s Only Friend, Number One, Best Friend, Friend Finder, The Book of Sin, Little Baggy, Venus, Boiled Baby, Telekinesis, Sagittarius, Inner Child, Rocket in a Jar, Dream Catcher, Robo-Baby, Plan C, Distant Admiration, Charged Baby, A Pound of Flesh, Old Bandage, Clear Rune, Steven (Item), The Negative, Zodiac, Broken Watch, Lil Gurdy, Jar of Wisps, Demon Baby, Mom's Underwear, D4, Blood Bombs, Void, The Scooper, Hungry Soul, Free Lemonade, Eraser, Scissors, Eye of Greed, Satanic Bible, Buddy in a Box, Bomb Bag, Little Chubby, Midnight Snack, Bird Cage, Rotten Tomato, Lil Delirium, Cupid's Arrow, Ipecac, Bum Friend, Mystery Egg, Anima Sola, D100, Lil Chest, Rotten Meat, Skatole, Empty Heart, Fate's Reward, Pay to Play, The Swarm, Cursed Eye

D Tier

Key Piece 2, Mercurius, Dinner, Dataminer, Sack of Sacks, Poke Go, Spider Bite, Slipped Rib, Juicy Sack, Lost Soul, Yuck Heart, Isaac's Heart, Hypercoagulation, Portable Slot, Mom's Wig, Abyss, Crack Jacks, 2Spooky, Ball of Bandages, Nancy Bombs, Belly Button, Heartbreak, The Boomerang, King Baby, The Pinking Shears, The Ladder, Berserk!, Vengeful Spirit, Brimstone Bombs, Smart Fly, Wavy Cap, Dull Razor, Recall, Placebo, Hot Bombs, Notched Axe, Mega Blast, Dr. Fetus, Sanguine Bond, Pageant Boy, Dark Prince's Crown, Mom's Razor, Breath of Life, Monster Manual, Flush!, Celtic Cross, Epic Fetus, Razor Blade, Strawman, Anti-Gravity, Tammy's Head, The Wiz, Sharp Key, Fruity Plum, Sister Maggy, Epiphora, Booster Pack (Item), Death's List, Mom's Box, Taurus, Supper, Lazarus' Rags, Shard of Glass, Bursting Sack, Dad's Lost Coin, Broken Glass Cannon, Ghost Baby, Black Powder, Mom's Bottle of Pills, A Quarter, Little Gish, Headless Baby, Robo-Baby 2.0, Abel, Acid Baby, Akeldama, Spelunker Hat, Missing No., Knife Piece 2, Vasculitis, D8, Mom's Bra, Unicorn Stump, Mr. Boom, Leo, It Hurts, Glass Cannon, The Poop, The Hourglass, Bucket of Lard, Blood Oath, Spin to Win, Lil Haunt, Hushy, Samson's Chains, Undefined, Fortune Cookie, Mom's Eyeshadow, Aries, Ankh, Anemic, D12, Friendly Ball, Tear Detonator, Betrayal, Curse of the Tower, Vade Retro, Red Candle, Dessert, Depression, The Jar, Bob's Rotten Head, Esau Jr., Ball of Tar, Wait What?, Hemoptysis, Remote Detonator, Missing Page 2, Marked, Battery Pack, Thunder Thighs, Bone Spurs, Spider Butt, Metronome, Punching Bag, Large Zit, Shade, Dead Sea Scrolls, Converter, Pause, Piggy Bank, Kidney Bean, Obsessed Fan, E. Coli, Forever Alone, Meat Cleaver, Telepathy for Dummies, <3, D10, Lil Spewer, The Gamekid, GB Bug, Bumbo, Milk!, Friend Zone, Strange Attractor, Tonsil, Leprosy, Mom's Heels, A Snack, Compost, Dad's Note, Mongo Baby, God's Flesh, Infestation, Mom's Coin Purse, Brown Nugget, The Necronomicon, Mom's Pad

F Tier

Clicker, Hold, Key Bum, Delirious, Lost Fly, The Bean, IBS, Sprinkler, Anarchist Cookbook, Mine Crafter, Dirty Mind, Farting Baby, Tinytoma, Broken Shovel, Angry Fly, Mom's Shovel, Mom's Bracelet, Bob's Brain, Keeper's Kin, Jar of Flies, TMTRAINER, Big Chubby, Knife Piece 1, Kamikaze!, Butter Bean, Linger Bean, The Black Bean, Blood Puppy