The Best Activated Items Tier List

171 Items2.5K Votes93 Voters
Updated October 19, 2025

A list of all activated items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 93 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.


Sort by

Filter by


S
A
B
C
D
F

Activated Item Tier List | The Binding of Isaac | Unduel