The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, Twisted Pair, Sacred Orb, Godhead, The D6, R Key, Holy Mantle, Mom's Knife, Spindown Dice, D Infinity, Tech X, Brimstone, Cricket's Head, Psy Fly, Incubus, Mutant Spider, Magic Mushroom, Jacob's Ladder, Trisagion, Crown of Light, Goat Head, A Lump of Coal, Holy Light, More Options, Stop Watch, Red Key, The Wafer, The Parasite, Rock Bottom, Pyromaniac, Apple!, Ceremonial Robes, Diplopia, Revelation, Athame, Eternal D6, Technology Zero, Birthright, Succubus, 20/20, Cricket's Body, Mega Mush, Chaos, Spoon Bender, The Stairway, Binge Eater, Flip, Polyphemus, Ghost Pepper, Pluto, Dead Eye, The Mark, Death's Touch, 8 Inch Nails, Abaddon, Bag of Crafting, The Mind, Head of the Keeper, Fire Mind, Host Hat, Immaculate Heart, Gnawed Leaf, Technology, Little Horn (Item), Haemolacria, The Small Rock, Dark Matter, Backstabber, The Pact, Money = Power, Steam Sale, Eye of Belial, Binky, Mystery Gift, Tech.5, Blood of the Martyr, Rubber Cement, Duality

B Tier

Tractor Beam, Black Candle, The Battery, Bird's Eye, Explosivo, Mucormycosis, Tough Love, Eden's Blessing, Placenta, Sausage, Lusty Blood, Ocular Rift, Soy Milk, Cat-O-Nine-Tails, Spirit Sword, Guppy's Tail, SMB Super Fan, The Halo, Stigmata, Growth Hormones, Cancer, Pentagram, Maw of the Void, Technology 2, Book of Revelations, Monstro's Lung, Dead Cat, Member Card, Tooth Picks, Paschal Candle, Wire Coat Hanger, Capricorn, Squeezy, Dead Dove, Holy Grail, Blue Map, Genesis, Knockout Drops, Daddy Longlegs, PJs, Rotten Baby, Libra, Champion Belt, Guppy's Eye, Forget Me Now, Eucharist, Book of Virtues, Fruit Cake, Eve's Mascara, Lodestone, Lemegeton, Lachryphagy, Damocles, YO LISTEN!, Sagittarius, Rosary, Proptosis, Almond Milk, Red Stew, Lost Contact, Euthanasia, Ipecac, The Sad Onion, Dogma (Item), Mom's Contacts, The Soul, Terra, Car Battery, Spider Mod, Sacrificial Altar, Star of Bethlehem, Voodoo Head, Sulfur, Dark Arts, Fate, Uranus, Humbleing Bundle, Mom's Pearls, Sharp Plug, My Reflection, Blanket, Mom's Key, Book of Shadows, Blank Card, Lead Pencil, Habit, Tarot Cloth, Mama Mega!, Sinus Infection, 4.5 Volt, Purity, 1up!, Mr. Dolly, Saturnus, The Inner Eye, Satanic Bible, Treasure Map, Synthoil, Toxic Shock, Stapler, Angelic Prism, Restock, Gimpy, Playdough Cookie, Lord of the Pit, Sulfuric Acid, Infamy, Bot Fly, Coupon, Roid Rage, The Ludovico Technique, Whore of Babylon, Sacrificial Dagger, Flat Stone, Monstrance, Eye of the Occult, Scapular, Tropicamide, A Dollar, Jumper Cables, Scorpio, Contagion, Dark Bum, Continuum, Dog Tooth, Spirit of the Night, 9 Volt, Void, We Need to Go Deeper!, The Intruder, Pyro, A Bar of Soap, 7 Seals, Leech, Guppy's Paw, 3 Dollar Bill, Eye Drops, Pisces, Lucky Foot, Gello, Act of Contrition, Guppy's Collar, Keeper's Sack, Serpent's Kiss, Odd Mushroom (Large), Blue Cap, Mysterious Liquid, Charm of the Vampire, Eden's Soul, Guppy's Head, X-Ray Vision, Chocolate Milk, Ouija Board, Infestation 2, Echo Chamber, Seraphim, Rune Bag, Salvation, Trinity Shield, Transcendence, Abyss, Neptunus, Glass Eye, Marbles, Torn Photo, Dad's Ring, Crystal Ball, Mitre, Worm Friend, Compound Fracture, Mom's Perfume, Pupula Duplex, Epic Fetus, Sack Head, PHD, Lil Dumpy, Dr. Fetus, Dead Onion, White Pony, Black Lotus, Charged Baby, The Body, Options?, Bloody Lust, Schoolbag, Alabaster Box, Fanny Pack, Freezer Baby, There's Options, Cambion Conception, Blood Bag, BFFS!, Urn of Souls, Camo Undies, Skeleton Key, Astral Projection, Kidney Stone

C Tier

Scatter Bombs, Contract From Below, Metal Plate, Pop!, Divorce Papers, Censer, Mr. ME!, Jesus Juice, Analog Stick, Lil Abaddon, Mom's Purse, False PHD, The Nail, Cupid's Arrow, Judas' Shadow, Mega Blast, Magic 8 Ball, Lil Brimstone, Mini Mush, Speed Ball, Divine Intervention, Adrenaline, Consolation Prize, Crooked Penny, Tiny Planet, Cube of Meat, Rotten Tomato, The Mulligan, Mom's Eye, Yum Heart, Glitter Bombs, Parasitoid, Odd Mushroom (Thin), The Compass, The Bible, Multidimensional Baby, Book of Secrets, The Relic, 120 Volt, D20, Sticky Bombs, Holy Water, Broken Modem, The Book of Belial, Loki's Horns, Iron Bar, Smelter, Midas' Touch, Sissy Longlegs, Chemical Peel, MEAT!, Magic Scab, Big Fan, Greed's Gullet, Screw, Hungry Soul, The Polaroid, Dry Baby, Gemini (Item), Anemic, Ghost Bombs, Black Hole, Orphan Socks, Azazel's Rage, Luna, Spider Bite, Virgo, Starter Deck, Lunch, Magic Skin, Little Steven, Book of the Dead, Safety Pin, Mars, Evil Charm, Bozo, Boom!, Maggy's Bow, Soul Locket, Mom's Ring, Aquarius, Moving Box, Dad's Lost Coin, Taurus, Marrow, Telepathy for Dummies, Papa Fly, A Pony, Hallowed Ground, Breakfast, Brother Bobby, Brittle Bones, Old Bandage, Shoop Da Whoop!, Guppy's Hair Ball, Empty Vessel, Raw Liver, Skatole, Cone Head, Deep Pockets, Quints, Dark Prince's Crown, Number One, Box of Friends, Plum Flute, Card Reading, Caffeine Pill, Spelunker Hat, Vanishing Twin, Lil Portal, The Common Cold, Prayer Card, Halo of Flies, Suplex!, Smart Fly, Tooth and Nail, Isaac's Tomb, Bogo Bombs, Blood Clot, Purgatory, Montezuma's Revenge, Dad's Key, Sack of Pennies, Mercurius, Anima Sola, Spear of Destiny, Eye of Greed, Belly Button, Cain's Other Eye, Buddy in a Box, Experimental Treatment, Evil Eye, Immaculate Conception, Acid Baby, Rocket in a Jar, Everything Jar, D1, Inner Child, Dream Catcher, Sol, Redemption, Glyph of Balance, Stye, Varicose Veins, Latch Key, Little C.H.A.D., Robo-Baby, No. 2, Thunder Thighs, Giant Cell, Bomber Boy, Spirit Shackles, Box of Spiders, Cracked Orb, The Negative, The Swarm, The Candle, The Book of Sin, Bloody Gust, Rainbow Baby, The Ladder, Epiphora, Robo-Baby 2.0, Steven (Item), Distant Admiration, Sad Bombs, Lil Monstro, Ankh, Lil Loki, Lost Soul, Mystery Sack, BBF, Boiled Baby, Spiderbaby, Hive Mind, The Peeper, Sumptorium, Black Powder, Harlequin Baby, Monster Manual, The Virus, Sworn Protector, Zodiac, Stem Cells, Large Zit, Venus, Tammy's Head, Wooden Nickel, Death's List, Recall, D100, Sister Maggy, Jaw Bone, Box, Berserk!, Bobby-Bomb, Glowing Hourglass, Pandora's Box, Butt Bombs, Polydactyly, Dead Bird, Stitches, Juicy Sack, Larynx, Bob's Curse, Mr. Mega, Belly Jelly, ???'s Only Friend, Fast Bombs, Glaucoma, Bloodshot Eye, Mom's Eyeshadow, Brimstone Bombs, Head of Krampus, Obsessed Fan, Cube Baby, Key Piece 1, My Shadow, Clear Rune, Betrayal

D Tier

Celtic Cross, Mongo Baby, Super Bandage, Bum Friend, A Pound of Flesh, Jar of Wisps, Bursting Sack, Vengeful Spirit, Night Light, D4, Fortune Cookie, Vade Retro, King Baby, Aries, A Quarter, The Belt, Circle of Protection, Finger!, Isaac's Tears, Vasculitis, Placebo, Lil Gurdy, Decap Attack, Blood Bombs, Midnight Snack, Mystery Egg, Pageant Boy, Mom's Razor, Lil Delirium, Hot Bombs, Crack the Sky, Keeper's Box, Friend Zone, Bone Spurs, My Little Unicorn, Lil Haunt, Pointy Rib, Bob's Brain, Little Baggy, Abel, Lil Chest, Lemon Mishap, Fate's Reward, The Hourglass, Hypercoagulation, Telekinesis, Deck of Cards, Sack of Sacks, Friendly Ball, Ghost Baby, Ball of Tar, Crack Jacks, Demon Baby, Ball of Bandages, Guardian Angel, Potato Peeler, Key Bum, Mom's Lipstick, Mom's Wig, Lazarus' Rags, 2Spooky, E. Coli, Glass Cannon, Fruity Plum, Match Book, Mom's Underwear, Metronome, Booster Pack (Item), Teleport 2.0, Leo, Magic Fingers, Tinytoma, Dead Tooth, Mom's Box, Piggy Bank, How to Jump, Broken Watch, Jupiter, Supper, Eye Sore, IV Bag, Undefined, Best Bud, Pay to Play, Hushy, Missing No., Wooden Spoon, Ventricle Razor, Candy Heart, D7, Empty Heart, Infestation, Rotten Meat, Mom's Bracelet, Dad's Note, Sharp Straw, Strange Attractor, Free Lemonade, Guillotine, Dull Razor, Cursed Eye, Lost Fly, Bucket of Lard, Razor Blade, Shade, Strawman, God's Flesh, Dessert, Mom's Bottle of Pills, Dinner, Esau Jr., Bomb Bag, Missing Page 2, Sanguine Bond, Scissors, Samson's Chains, The Poop, The Pinking Shears, Mr. Boom, Bird Cage, Hemoptysis, TMTRAINER, Mom's Coin Purse, Blood Oath, Portable Slot, Converter, Depression, Blood Rights, Anti-Gravity, Dirty Mind, Isaac's Heart, Key Piece 2, Red Candle, Teleport!, Battery Pack, Breath of Life, Unicorn Stump, Linger Bean, Punching Bag, Delirious, Milk!, The Boomerang, The Necronomicon, Akeldama, Yuck Heart, Headless Baby, Wavy Cap, Nancy Bombs, Clicker, Notched Axe, Mom's Bra, It Hurts, Angry Fly, Little Gish, Heartbreak, Plan C, Poke Go, Eraser, Dead Sea Scrolls, <3, D8, A Snack, Doctor's Remote, Sprinkler, Flush!, Spider Butt, Magneto, Best Friend, IBS, Friend Finder, Hold, The Gamekid, Slipped Rib, GB Bug, Forever Alone, Lil Spewer, Tonsil, Meat Cleaver, Leprosy, The Wiz, Mom's Heels, Remote Detonator, Mega Bean, Brown Nugget, Compost, Tear Detonator, Kamikaze!, Spin to Win, Wait What?, Little Chubby, Dataminer, Mine Crafter, Knife Piece 2, Marked, Anarchist Cookbook, Blood Puppy, Monstro's Tooth, Bob's Rotten Head, The Scooper, D12, Farting Baby, The Jar, Broken Glass Cannon, Shard of Glass, The Bean, D10, Big Chubby, Golden Razor, Kidney Bean, Mom's Shovel, Sharp Key, Curse of the Tower, Jar of Flies, Pause, Knife Piece 1, Keeper's Kin, The Black Bean, Bumbo, Butter Bean, Broken Shovel

F Tier

Mom's Pad