The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, R Key, Twisted Pair, The D6, Godhead, Sacred Orb, Holy Mantle, Mom's Knife, Spindown Dice, Brimstone, Rock Bottom, Tech X, Incubus, D Infinity, Cricket's Head, Psy Fly, Magic Mushroom, Crown of Light, Jacob's Ladder, Goat Head, Holy Light, Mutant Spider, The Parasite, Ghost Pepper, More Options, Chaos, Succubus, Trisagion, Birthright, Diplopia, The Wafer, Revelation, Stop Watch, Dead Eye, Pyromaniac, The Stairway, Red Key, Death's Touch, Spirit Sword, Spoon Bender, Host Hat, Technology, Abaddon, Eucharist, 20/20, Ceremonial Robes, Apple!, Mega Mush, Polyphemus, Immaculate Heart, Cricket's Body, Backstabber, Tough Love, Technology Zero, A Lump of Coal, Athame, Tractor Beam, Sausage, The Halo, Haemolacria, The Pact, The Mark, Mystery Gift, 8 Inch Nails, Maw of the Void, Proptosis, Eye of Belial, Guppy's Eye, Star of Bethlehem, Explosivo, Head of the Keeper, PHD, Bird's Eye, Dead Cat, Flip, Mucormycosis, Pluto, Rubber Cement, Blood of the Martyr, Black Candle, The Mind, SMB Super Fan, Dead Dove, Pentagram, Genesis, Eternal D6, Capricorn, Dark Matter

B Tier

Terra, YO LISTEN!, Ocular Rift, Little Horn (Item), Eden's Blessing, Lusty Blood, Fruit Cake, Lord of the Pit, Binge Eater, Damocles, Fire Mind, Tech.5, Money = Power, Book of Virtues, My Reflection, Daddy Longlegs, Book of Revelations, Euthanasia, Squeezy, Cat-O-Nine-Tails, Holy Grail, Purity, The Soul, Stigmata, Humbleing Bundle, Mom's Key, Lachryphagy, Soy Milk, Steam Sale, Forget Me Now, Infestation 2, The Small Rock, Binky, Lucky Foot, 1up!, Uranus, Member Card, Toxic Shock, Cancer, Eve's Mascara, Rotten Baby, Ipecac, Car Battery, Mama Mega!, Synthoil, Red Stew, Libra, Monstro's Lung, The Sad Onion, 9 Volt, Divorce Papers, Growth Hormones, Sulfuric Acid, Gnawed Leaf, Worm Friend, Paschal Candle, Mysterious Liquid, Seraphim, Restock, Technology 2, The Battery, Wire Coat Hanger, Mom's Contacts, Stapler, Camo Undies, Echo Chamber, Blue Map, The Inner Eye, Lemegeton, Spirit of the Night, Mr. Dolly, Infamy, Dogma (Item), Dark Arts, Lost Contact, Continuum, Bot Fly, Habit, Sharp Plug, Eye of the Occult, Duality, Angelic Prism, Black Lotus, Bag of Crafting, Options?, Lead Pencil, A Dollar, Saturnus, Guppy's Tail, Lil Brimstone, 4.5 Volt, PJs, Champion Belt, Lil Abaddon, Whore of Babylon, Eden's Soul, Sagittarius, Act of Contrition, There's Options, Dark Bum, Gimpy, BFFS!, Tooth Picks, Blue Cap, Scorpio, Compound Fracture, Dog Tooth, Sulfur, Mitre, Book of Shadows, Satanic Bible, Neptunus, The Body, We Need to Go Deeper!, Pisces, Sinus Infection, Mom's Ring, Sack Head, Crooked Penny, Rosary, Torn Photo, Knockout Drops, Mr. ME!, Glass Eye, Schoolbag, The Relic, Eye Drops, Blank Card, Holy Water, X-Ray Vision, Voodoo Head, Flat Stone, Jumper Cables, Alabaster Box, Void, Epic Fetus, Cupid's Arrow, Monstrance, Lil Dumpy, Brittle Bones, Broken Modem, Coupon, The Book of Belial, 3 Dollar Bill, Pyro, Odd Mushroom (Large), Trinity Shield, Treasure Map, Ouija Board, Scapular, Serpent's Kiss, Dead Onion, Charm of the Vampire, Luna, Censer, Guppy's Collar, Gello, Crystal Ball, Odd Mushroom (Thin), The Intruder, Chocolate Milk, Playdough Cookie, Virgo, Urn of Souls, Keeper's Sack, Blanket, 120 Volt, Salvation, 7 Seals, Abyss, Dr. Fetus, Placenta, Tarot Cloth, Mom's Pearls, Steven (Item), Contagion, Fanny Pack, Lodestone, Skeleton Key, Spider Mod, Guppy's Head, Guppy's Paw, Sacrificial Altar, Roid Rage, A Bar of Soap, Divine Intervention, Rune Bag, Dream Catcher, Bloody Lust, Starter Deck, Prayer Card, Fate, D20, White Pony, Pupula Duplex

C Tier

Tropicamide, False PHD, Pandora's Box, The Ludovico Technique, Cube of Meat, Sacrificial Dagger, Box of Friends, The Compass, Transcendence, Freezer Baby, Pop!, Mega Blast, Judas' Shadow, Sol, Orphan Socks, Telepathy for Dummies, Kidney Stone, Clear Rune, Old Bandage, Deep Pockets, Jesus Juice, Marbles, Screw, Leech, MEAT!, Charged Baby, Mini Mush, Raw Liver, Aquarius, Dad's Ring, Glowing Hourglass, The Polaroid, Cambion Conception, Book of the Dead, Rotten Tomato, Almond Milk, Dry Baby, Spelunker Hat, A Pony, Hungry Soul, Mars, Midas' Touch, Spear of Destiny, The Nail, Parasitoid, Cone Head, Tooth and Nail, Cube Baby, Contract From Below, Guardian Angel, Suplex!, Loki's Horns, Iron Bar, Tiny Planet, Quints, Blood Clot, Lil Loki, Maggy's Bow, The Mulligan, Bloody Gust, Evil Charm, Tammy's Head, Mom's Perfume, Belly Jelly, Hive Mind, Mercurius, Rocket in a Jar, Bozo, Mom's Eye, Mongo Baby, Blood Bag, Ghost Bombs, Yum Heart, Consolation Prize, Wooden Nickel, Analog Stick, Safety Pin, Cain's Other Eye, Mom's Box, Redemption, Sworn Protector, Dad's Key, D100, The Negative, Multidimensional Baby, Buddy in a Box, Magic Scab, Big Fan, Latch Key, Moving Box, Aries, Lil Delirium, Adrenaline, Vanishing Twin, Soul Locket, Lil Chest, The Swarm, Venus, Chemical Peel, Lil Portal, Little Steven, Sack of Pennies, Astral Projection, Mom's Purse, Belly Button, Dad's Lost Coin, Polydactyly, Card Reading, Evil Eye, Halo of Flies, Azazel's Rage, Robo-Baby, Metal Plate, Magic 8 Ball, Empty Vessel, Book of Secrets, Number One, Death's List, The Bible, Epiphora, Crack Jacks, Stitches, Gemini (Item), Inner Child, Stem Cells, A Quarter, Lil Monstro, Speed Ball, Anti-Gravity, Anima Sola, Purgatory, Hallowed Ground, Deck of Cards, Brother Bobby, Booster Pack (Item), The Virus, Magic Skin, Brimstone Bombs, Ghost Baby, Mr. Mega, Spirit Shackles, Immaculate Conception, Demon Baby, Glitter Bombs, Bogo Bombs, Finger!, Ankh, Dark Prince's Crown, Harlequin Baby, Boom!, Zodiac, Red Candle, Scatter Bombs, Sad Bombs, Smelter, Shoop Da Whoop!, 2Spooky, Butt Bombs, Spiderbaby, Black Hole, Fate's Reward, D1, Robo-Baby 2.0, Celtic Cross, The Candle, Anemic, Sticky Bombs, Circle of Protection, The Common Cold, No. 2, Everything Jar, Pageant Boy, Greed's Gullet, Notched Axe, Bursting Sack, Juicy Sack, Sissy Longlegs, Vengeful Spirit, Bloodshot Eye, The Ladder, Eye Sore, Jupiter, Glyph of Balance, Little C.H.A.D., Hypercoagulation, Skatole, Fruity Plum, The Peeper, Cracked Orb, Wooden Spoon, Blood Bombs, The Book of Sin, Mystery Sack, Montezuma's Revenge, Rainbow Baby, Teleport 2.0, Breakfast, Boiled Baby, Ball of Tar, Smart Fly, Telekinesis, Eraser, Potato Peeler, Piggy Bank, Key Piece 1, Marrow, Guillotine, Varicose Veins, Headless Baby, Eye of Greed, Lost Soul, Bone Spurs, Bomber Boy, Stye, Placebo, IV Bag, Super Bandage, Ball of Bandages, King Baby, Papa Fly, Isaac's Tomb, Caffeine Pill, Spider Bite, Jaw Bone, Fortune Cookie, Bobby-Bomb, Lunch, Recall, Dull Razor, Midnight Snack, <3, Plum Flute

D Tier

Isaac's Tears, Large Zit, Vade Retro, Fast Bombs, The Belt, A Snack, Guppy's Hair Ball, Little Gish, Betrayal, Berserk!, How to Jump, Sack of Sacks, Black Powder, Taurus, Crack the Sky, Esau Jr., Sister Maggy, Mom's Eyeshadow, My Little Unicorn, Wavy Cap, The Pinking Shears, Delirious, Glaucoma, Lil Haunt, Distant Admiration, ???'s Only Friend, Candy Heart, Monster Manual, Box, Sumptorium, Glass Cannon, Lost Fly, Head of Krampus, Experimental Treatment, Breath of Life, Nancy Bombs, D4, Mom's Wig, Box of Spiders, Lil Gurdy, Night Light, Dead Bird, Bomb Bag, It Hurts, Acid Baby, Dead Tooth, Mr. Boom, Battery Pack, Hot Bombs, Tinytoma, Slipped Rib, The Necronomicon, Dirty Mind, Dessert, Mom's Bottle of Pills, Vasculitis, Lazarus' Rags, Little Chubby, Broken Watch, My Shadow, Bird Cage, Giant Cell, Strawman, Mom's Razor, D7, Unicorn Stump, Dinner, Hemoptysis, Rotten Meat, Undefined, The Boomerang, BBF, Abel, Bob's Curse, Larynx, Pay to Play, Supper, Sprinkler, Pointy Rib, Jar of Wisps, Plan C, Depression, Mom's Lipstick, Sanguine Bond, God's Flesh, Hushy, Bum Friend, Farting Baby, Friend Finder, The Hourglass, Mega Bean, Mystery Egg, Angry Fly, Leo, Key Piece 2, Magic Fingers, Thunder Thighs, Bucket of Lard, Poke Go, Mom's Coin Purse, D8, Keeper's Box, Heartbreak, Match Book, Isaac's Heart, Decap Attack, Metronome, A Pound of Flesh, Friendly Ball, Free Lemonade, Mom's Heels, Linger Bean, Shard of Glass, Flush!, Mom's Underwear, Best Bud, Sharp Key, Mine Crafter, Friend Zone, Key Bum, Bob's Rotten Head, The Gamekid, Missing Page 2, Akeldama, Big Chubby, Sharp Straw, Obsessed Fan, The Wiz, Samson's Chains, Converter, Doctor's Remote, Razor Blade, Bob's Brain, Spider Butt, Milk!, Mom's Bracelet, Marked, Forever Alone, Monstro's Tooth, Scissors, Blood Puppy, The Scooper, Ventricle Razor, TMTRAINER, Blood Oath, Leprosy, Portable Slot, Empty Heart, Cursed Eye, Brown Nugget, Lil Spewer, Kamikaze!, E. Coli, Infestation, Magneto, Jar of Flies, Wait What?, Strange Attractor, Knife Piece 2, Dad's Note, Bumbo, Punching Bag, Teleport!, Little Baggy, Missing No., Mom's Shovel, GB Bug, Lemon Mishap, Mom's Bra, IBS, Remote Detonator, Tear Detonator, D10, Compost, Best Friend, Blood Rights, D12, Shade, The Poop, Anarchist Cookbook, Dead Sea Scrolls, The Jar, Yuck Heart, Dataminer, Tonsil, Meat Cleaver, Hold, Keeper's Kin, Golden Razor, Spin to Win, The Bean, Broken Shovel, Clicker, Curse of the Tower, Broken Glass Cannon, Butter Bean, Knife Piece 1, Pause, Kidney Bean

F Tier

The Black Bean, Mom's Pad