The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, Twisted Pair, R Key, The D6, Godhead, Sacred Orb, Mom's Knife, Holy Mantle, Spindown Dice, Brimstone, Tech X, Rock Bottom, Incubus, D Infinity, Psy Fly, Cricket's Head, Goat Head, Magic Mushroom, Jacob's Ladder, Crown of Light, Mutant Spider, The Parasite, Trisagion, Red Key, Holy Light, Birthright, A Lump of Coal, Ghost Pepper, Chaos, Succubus, The Wafer, Stop Watch, More Options, Athame, Diplopia, The Stairway, Pyromaniac, Revelation, Dead Eye, Ceremonial Robes, Spirit Sword, Technology Zero, Abaddon, Technology, Immaculate Heart, Mega Mush, Backstabber, 20/20, The Mark, Polyphemus, Eucharist, The Halo, Host Hat, Sausage, Apple!, Tough Love, Death's Touch, Haemolacria, Eye of Belial, Tractor Beam, Cricket's Body, SMB Super Fan, Spoon Bender, Blood of the Martyr, Mystery Gift, The Pact, Eternal D6, Pluto, Capricorn, Maw of the Void, Black Candle, Guppy's Eye, Flip, Head of the Keeper, Bird's Eye, 8 Inch Nails, Terra, Proptosis, YO LISTEN!, Lusty Blood, Binge Eater, The Mind, Ocular Rift, Book of Revelations, Explosivo, Pentagram, Mucormycosis, Star of Bethlehem, Tech.5, Cancer, Rubber Cement, Rotten Baby, Dark Matter, Fire Mind, Lachryphagy, The Soul, Genesis, Dead Cat, Dead Dove, Daddy Longlegs, Money = Power, My Reflection, Bag of Crafting, Eden's Blessing, Book of Virtues

B Tier

Holy Grail, Lord of the Pit, Dogma (Item), Damocles, Fruit Cake, Growth Hormones, Little Horn (Item), Paschal Candle, Cat-O-Nine-Tails, Technology 2, PHD, The Small Rock, Stigmata, Forget Me Now, The Sad Onion, Infestation 2, Eye of the Occult, Binky, Worm Friend, Purity, Ipecac, 4.5 Volt, Lead Pencil, Squeezy, Steam Sale, Lemegeton, Soy Milk, Car Battery, Mr. Dolly, Guppy's Tail, The Battery, Euthanasia, 9 Volt, Lucky Foot, Continuum, Humbleing Bundle, Libra, Mom's Contacts, Mom's Key, Mama Mega!, Monstro's Lung, Wire Coat Hanger, Eve's Mascara, Dark Arts, Camo Undies, Uranus, Rosary, Seraphim, Red Stew, Lil Brimstone, Angelic Prism, The Inner Eye, Bot Fly, Blue Map, Voodoo Head, Echo Chamber, Restock, Gnawed Leaf, Member Card, 1up!, Mysterious Liquid, Infamy, Book of Shadows, Stapler, Champion Belt, Divorce Papers, Lost Contact, A Dollar, Blank Card, There's Options, Spirit of the Night, Toxic Shock, Sulfuric Acid, X-Ray Vision, Lil Abaddon, Saturnus, Mom's Ring, Act of Contrition, PJs, Sagittarius, Sack Head, Torn Photo, Gimpy, Satanic Bible, Sharp Plug, Dark Bum, Habit, Synthoil, Scorpio, Dog Tooth, We Need to Go Deeper!, Black Lotus, Mitre, Whore of Babylon, Duality, Knockout Drops, Neptunus, Sulfur, Compound Fracture, Playdough Cookie, Treasure Map, Odd Mushroom (Large), Schoolbag, Blanket, Epic Fetus, Blue Cap, Lil Dumpy, Rune Bag, Placenta, Glass Eye, Monstrance, Ouija Board, Tooth Picks, Chocolate Milk, The Body, Dead Onion, The Relic, Eden's Soul, Eye Drops, Void, Roid Rage, Virgo, Alabaster Box, Mom's Pearls, Sinus Infection, Options?, 3 Dollar Bill, A Pony, Flat Stone, Cupid's Arrow, Lodestone, Broken Modem, The Polaroid, Pyro, The Intruder, Crooked Penny, Crystal Ball, Prayer Card, Dr. Fetus, Odd Mushroom (Thin), Contagion, Jumper Cables, Keeper's Sack, 7 Seals, Charm of the Vampire, BFFS!, Gello, Marbles, Brittle Bones, Charged Baby, Pisces, Guppy's Paw, Holy Water, Leech, Guppy's Collar, Serpent's Kiss, Luna, Transcendence, Urn of Souls, Scapular, The Book of Belial, Coupon, Salvation, Mr. ME!, Trinity Shield, The Ludovico Technique, Judas' Shadow, Abyss, A Bar of Soap, Freezer Baby, Fate, Sacrificial Altar, False PHD, Censer, Parasitoid, Sacrificial Dagger, Skeleton Key, Blood Clot, Divine Intervention, Pupula Duplex, D20, Starter Deck, Spelunker Hat, Quints, Almond Milk, Tropicamide, White Pony, Orphan Socks, Bloody Lust, Dad's Ring, Hungry Soul, Spider Mod, Aquarius, Dream Catcher

C Tier

Mini Mush, Sol, Cube of Meat, Cain's Other Eye, Mega Blast, Steven (Item), Guppy's Head, Analog Stick, Cone Head, The Mulligan, Pop!, Clear Rune, Ghost Bombs, Tarot Cloth, Lil Loki, Dry Baby, Magic Scab, 120 Volt, Jesus Juice, Midas' Touch, The Negative, Fanny Pack, The Compass, Maggy's Bow, Kidney Stone, Raw Liver, Consolation Prize, Bloody Gust, Box of Friends, The Swarm, Mercurius, MEAT!, Spear of Destiny, Bozo, Iron Bar, Cambion Conception, Telepathy for Dummies, Multidimensional Baby, Mom's Purse, Contract From Below, The Nail, Screw, Book of the Dead, Mom's Eye, Lil Monstro, Rocket in a Jar, Buddy in a Box, Mars, Belly Button, Black Hole, Deep Pockets, Yum Heart, Inner Child, Tiny Planet, Suplex!, Astral Projection, Mongo Baby, Glowing Hourglass, Mom's Perfume, Big Fan, Chemical Peel, D100, Blood Bag, Little Steven, Book of Secrets, Moving Box, Old Bandage, Anti-Gravity, Rotten Tomato, Tooth and Nail, The Common Cold, Belly Jelly, Pandora's Box, Magic 8 Ball, The Peeper, Death's List, Cube Baby, Sworn Protector, Aries, Adrenaline, Halo of Flies, Loki's Horns, Tammy's Head, Safety Pin, Scatter Bombs, Guardian Angel, Dad's Lost Coin, Fate's Reward, Metal Plate, Hive Mind, Harlequin Baby, Redemption, Glitter Bombs, Super Bandage, The Bible, Lil Portal, Ankh, Sissy Longlegs, Soul Locket, Azazel's Rage, Brother Bobby, Dad's Key, Gemini (Item), Smelter, Evil Eye, Demon Baby, Vanishing Twin, Celtic Cross, D1, Boom!, Card Reading, Stitches, Evil Charm, Smart Fly, Anemic, Empty Vessel, Shoop Da Whoop!, Speed Ball, Sack of Pennies, Finger!, Wooden Nickel, Robo-Baby, Fruity Plum, Greed's Gullet, The Virus, Dark Prince's Crown, Spiderbaby, Montezuma's Revenge, Sticky Bombs, Lil Chest, Rainbow Baby, Glyph of Balance, Everything Jar, Hallowed Ground, Ghost Baby, Skatole, Immaculate Conception, Booster Pack (Item), Lil Delirium, Robo-Baby 2.0, Magic Skin, Butt Bombs, Stye, Brimstone Bombs, Sad Bombs, Bogo Bombs, Latch Key, The Candle, Boiled Baby, Caffeine Pill, No. 2, Eraser, Telekinesis, Zodiac, Venus, Cracked Orb, The Book of Sin, Ball of Bandages, Juicy Sack, Mr. Mega, Blood Bombs, Stem Cells, Number One, Spirit Shackles, Epiphora, Notched Axe, Guillotine, Mom's Box, Lost Soul, Circle of Protection, Breakfast, Purgatory, Black Powder, Sack of Sacks, Jupiter, Large Zit, Anima Sola, Mystery Sack, Marrow, ???'s Only Friend, Eye of Greed, Bloodshot Eye, Bomber Boy, Wooden Spoon, My Little Unicorn, Red Candle, Little C.H.A.D., Polydactyly, Spider Bite, Pageant Boy, Guppy's Hair Ball, Bursting Sack, Lil Gurdy, King Baby, Teleport 2.0, Ball of Tar, Vade Retro, Papa Fly, Crack the Sky, Midnight Snack, Bone Spurs, Lunch, Potato Peeler, Piggy Bank, Acid Baby, Hypercoagulation, The Ladder, Eye Sore, A Quarter, 2Spooky, Key Piece 1, Sister Maggy, Headless Baby, Recall, Dead Bird, Hot Bombs, Distant Admiration, Taurus, Lost Fly

D Tier

Esau Jr., Varicose Veins, Box of Spiders, Little Chubby, It Hurts, Monster Manual, Isaac's Tears, Mom's Eyeshadow, Fast Bombs, Placebo, Isaac's Tomb, Vengeful Spirit, Bobby-Bomb, A Snack, D7, My Shadow, Little Gish, Head of Krampus, Berserk!, Deck of Cards, Night Light, Breath of Life, Jaw Bone, Abel, D4, Betrayal, The Belt, Bum Friend, Plum Flute, Lazarus' Rags, Leo, How to Jump, BBF, Dead Tooth, Mr. Boom, Thunder Thighs, Vasculitis, Pointy Rib, Bob's Curse, Lil Haunt, Tinytoma, Slipped Rib, Nancy Bombs, Hushy, IV Bag, Mom's Lipstick, <3, Dinner, Larynx, Jar of Wisps, Dull Razor, Fortune Cookie, Rotten Meat, Giant Cell, Crack Jacks, Mom's Wig, Experimental Treatment, Sprinkler, Sumptorium, Glass Cannon, Bomb Bag, Delirious, Wavy Cap, Depression, Sanguine Bond, Candy Heart, Mom's Bottle of Pills, The Necronomicon, The Pinking Shears, Dirty Mind, Box, Bird Cage, Glaucoma, Broken Watch, Battery Pack, Strawman, Bucket of Lard, Hemoptysis, Decap Attack, Friend Finder, Friend Zone, Heartbreak, Obsessed Fan, Unicorn Stump, Match Book, Isaac's Heart, Bob's Brain, Poke Go, Plan C, The Wiz, Mom's Razor, Linger Bean, Best Bud, God's Flesh, Magic Fingers, Shard of Glass, Supper, Key Bum, Big Chubby, Pay to Play, D8, The Gamekid, Keeper's Box, Milk!, Mom's Underwear, Dessert, Farting Baby, Undefined, Lil Spewer, Mom's Coin Purse, Friendly Ball, Portable Slot, Akeldama, Angry Fly, Converter, Infestation, The Hourglass, Mystery Egg, Key Piece 2, The Boomerang, Doctor's Remote, Leprosy, Mom's Bracelet, Scissors, Samson's Chains, Sharp Straw, A Pound of Flesh, Strange Attractor, Mom's Heels, Ventricle Razor, TMTRAINER, Missing Page 2, Cursed Eye, Empty Heart, Flush!, Metronome, Free Lemonade, Razor Blade, Punching Bag, E. Coli, Forever Alone, Blood Puppy, Blood Oath, GB Bug, Spider Butt, Bob's Rotten Head, Mom's Shovel, Dad's Note, Mine Crafter, The Scooper, Knife Piece 2, Best Friend, Marked, Bumbo, Remote Detonator, Lemon Mishap, Shade, Teleport!, Kamikaze!, Mega Bean, Dead Sea Scrolls, IBS, Magneto, Golden Razor, Wait What?, Mom's Bra, Tonsil, Brown Nugget, Little Baggy, Yuck Heart, Sharp Key, Clicker, Missing No., Monstro's Tooth, Hold, Keeper's Kin, Anarchist Cookbook, Tear Detonator, Compost, Curse of the Tower, Broken Shovel, The Jar, The Poop, Blood Rights, Meat Cleaver, Jar of Flies, Kidney Bean, Dataminer, Spin to Win, The Bean, Broken Glass Cannon, D10, D12, Butter Bean, Pause, The Black Bean

F Tier

Knife Piece 1, Mom's Pad