The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, Twisted Pair, Godhead, Sacred Orb, R Key, The D6, Holy Mantle, Spindown Dice, Mom's Knife, D Infinity, Brimstone, Tech X, Cricket's Head, Psy Fly, Incubus, Magic Mushroom, Mutant Spider, Goat Head, Crown of Light, Jacob's Ladder, Trisagion, A Lump of Coal, Rock Bottom, Red Key, The Parasite, Ceremonial Robes, Birthright, The Wafer, More Options, Holy Light, Stop Watch, Apple!, Pyromaniac, Diplopia, Revelation, Succubus, The Stairway, Chaos, Athame, Eternal D6, Technology Zero, Ghost Pepper, 20/20, Mega Mush, Dead Eye, Binge Eater, Technology, Polyphemus, Spoon Bender, Cricket's Body, Gnawed Leaf, The Mark, Death's Touch, Host Hat, Flip, Eye of Belial, 8 Inch Nails, The Pact, Tractor Beam, Pluto, Immaculate Heart, Backstabber, Abaddon, Spirit Sword, Haemolacria, Mystery Gift, Steam Sale, Bird's Eye, Blood of the Martyr, Tough Love, Little Horn (Item), Head of the Keeper, Star of Bethlehem, Black Candle, The Mind, Holy Grail, Lusty Blood, Maw of the Void, Dark Matter, Eucharist, Binky, The Halo, Fruit Cake, Growth Hormones, Dead Dove, Bag of Crafting, Dead Cat, Pentagram, Rotten Baby, Sausage, Fire Mind, Tech.5, Lachryphagy, YO LISTEN!, Rubber Cement, Explosivo, Paschal Candle, Libra, Book of Revelations, Genesis, Ocular Rift, Eden's Blessing, Terra, The Small Rock, Dogma (Item), Squeezy, SMB Super Fan, Money = Power

B Tier

Lost Contact, Monstro's Lung, Daddy Longlegs, Lemegeton, Cancer, Cat-O-Nine-Tails, Mucormycosis, Capricorn, Proptosis, Guppy's Tail, The Battery, Forget Me Now, Stigmata, Guppy's Eye, Purity, Wire Coat Hanger, Fate, Technology 2, Voodoo Head, Book of Shadows, Lodestone, Sharp Plug, Damocles, Eve's Mascara, Lord of the Pit, Member Card, Book of Virtues, Blue Map, Ipecac, The Inner Eye, The Soul, Toxic Shock, Mama Mega!, Uranus, Duality, Knockout Drops, Dark Arts, Placenta, Red Stew, Champion Belt, Humbleing Bundle, Rosary, Seraphim, Car Battery, The Sad Onion, Eye of the Occult, Soy Milk, Spirit of the Night, Mr. Dolly, Angelic Prism, Satanic Bible, Stapler, A Dollar, 9 Volt, Saturnus, My Reflection, Habit, Sagittarius, Euthanasia, Synthoil, Camo Undies, We Need to Go Deeper!, Continuum, PJs, Dog Tooth, Infestation 2, Coupon, Lil Dumpy, Sulfur, Blanket, Mom's Contacts, Restock, Whore of Babylon, Lil Brimstone, Tooth Picks, Pyro, Salvation, Compound Fracture, Act of Contrition, Odd Mushroom (Large), Rune Bag, Black Lotus, PHD, Roid Rage, Sinus Infection, Neptunus, The Ludovico Technique, Bot Fly, Playdough Cookie, Worm Friend, Lead Pencil, Tarot Cloth, Scapular, X-Ray Vision, Gimpy, Guppy's Paw, 4.5 Volt, Chocolate Milk, Lil Abaddon, Gello, Lucky Foot, Sacrificial Altar, Eden's Soul, Dead Onion, There's Options, Scorpio, Infamy, Mom's Key, Serpent's Kiss, The Body, Sulfuric Acid, Void, Keeper's Sack, Monstrance, Blue Cap, Flat Stone, BFFS!, 1up!, Almond Milk, Sack Head, Crystal Ball, Mom's Pearls, Ouija Board, Jumper Cables, Judas' Shadow, Blood Bag, Echo Chamber, Mitre, Blank Card, Pisces, A Bar of Soap, Mysterious Liquid, Epic Fetus, The Relic, 3 Dollar Bill, The Intruder, Dark Bum, Dr. Fetus, Parasitoid, Fanny Pack, Abyss, Trinity Shield, 7 Seals, Guppy's Collar, Guppy's Head, Cambion Conception, The Mulligan, Sacrificial Dagger, Charged Baby, Treasure Map, Schoolbag, Contagion, Options?, Censer, Spider Mod, Charm of the Vampire, Odd Mushroom (Thin), The Polaroid, Eye Drops, Glass Eye, Virgo, Transcendence, Mr. ME!, Marbles, Divorce Papers, Urn of Souls, Cupid's Arrow, Starter Deck, False PHD, Dad's Ring, Mini Mush, White Pony, Tropicamide, Bloody Lust, Freezer Baby, Divine Intervention, Leech, Crooked Penny, Dry Baby, Little Steven, Consolation Prize, Mega Blast, Speed Ball, Jesus Juice, Mom's Ring, Multidimensional Baby, Book of Secrets, Cube of Meat, Broken Modem, Torn Photo, Old Bandage, Analog Stick, Holy Water

C Tier

Yum Heart, The Nail, Luna, Astral Projection, Magic Scab, Mars, Magic 8 Ball, The Book of Belial, Kidney Stone, A Pony, Skeleton Key, Ghost Bombs, Alabaster Box, Screw, Maggy's Bow, Brittle Bones, Contract From Below, The Compass, Quints, Pop!, Mom's Perfume, Scatter Bombs, Orphan Socks, Sissy Longlegs, Montezuma's Revenge, 120 Volt, Sol, Loki's Horns, The Bible, Glitter Bombs, Soul Locket, Tooth and Nail, Hungry Soul, Rotten Tomato, Adrenaline, Cain's Other Eye, Prayer Card, Aquarius, Cone Head, Inner Child, Mercurius, Mom's Purse, D20, Pupula Duplex, Redemption, Box of Friends, Steven (Item), Tiny Planet, Book of the Dead, Lil Loki, Chemical Peel, Glyph of Balance, Spelunker Hat, Mom's Eye, Telepathy for Dummies, Black Hole, Marrow, Ankh, Midas' Touch, Iron Bar, MEAT!, Gemini (Item), Spider Bite, Robo-Baby, The Negative, Bozo, Empty Vessel, Buddy in a Box, Sticky Bombs, Dream Catcher, Brother Bobby, Raw Liver, Metal Plate, Caffeine Pill, Spear of Destiny, Belly Jelly, Card Reading, Everything Jar, Big Fan, Boom!, Death's List, Evil Charm, Anemic, The Peeper, Immaculate Conception, Suplex!, Dad's Lost Coin, Dark Prince's Crown, Smart Fly, Smelter, Glowing Hourglass, Mongo Baby, Pandora's Box, Sad Bombs, D1, Purgatory, Epiphora, Bloody Gust, Breakfast, Hallowed Ground, Deep Pockets, Acid Baby, Super Bandage, Lil Monstro, The Candle, Belly Button, Robo-Baby 2.0, Anima Sola, Isaac's Tomb, Evil Eye, Recall, Bogo Bombs, D100, The Book of Sin, Number One, Guppy's Hair Ball, Hive Mind, Taurus, Harlequin Baby, Demon Baby, No. 2, The Ladder, Rocket in a Jar, Bomber Boy, Papa Fly, Blood Clot, Lunch, Safety Pin, The Common Cold, Moving Box, Sworn Protector, King Baby, Butt Bombs, Halo of Flies, Larynx, Stitches, Deck of Cards, Greed's Gullet, Shoop Da Whoop!, Azazel's Rage, Brimstone Bombs, Vanishing Twin, Stye, Lazarus' Rags, Magic Skin, Dad's Key, Sack of Pennies, Lil Portal, Clear Rune, Spiderbaby, Cracked Orb, Large Zit, Skatole, Monster Manual, Latch Key, Blood Bombs, Ghost Baby, Boiled Baby, Wooden Nickel, Tammy's Head, The Swarm, Rainbow Baby, Stem Cells, ???'s Only Friend, Lil Chest, Box, Aries, Black Powder, Spirit Shackles, Lil Gurdy, Celtic Cross, Anti-Gravity, Eye of Greed, Mystery Sack, Cube Baby, Venus, Bloodshot Eye, Mr. Mega, Ball of Bandages, Distant Admiration, Circle of Protection, D4, Zodiac, Fruity Plum, Fast Bombs, Hot Bombs, A Quarter, Vengeful Spirit, Bobby-Bomb, Plum Flute, Berserk!, Bone Spurs, Bob's Curse, Lost Soul, Dead Bird, Telekinesis, Little C.H.A.D., BBF, Obsessed Fan, Lost Fly, Box of Spiders, Experimental Treatment, Varicose Veins, Placebo, Abel, Crack Jacks, Finger!, My Shadow, Bursting Sack, Sumptorium, Vade Retro, The Virus, Giant Cell

D Tier

Guardian Angel, Fortune Cookie, Decap Attack, Sanguine Bond, Polydactyly, IV Bag, Lil Delirium, Magic Fingers, Sister Maggy, The Belt, Key Piece 1, Mom's Eyeshadow, Jar of Wisps, Juicy Sack, Head of Krampus, Wooden Spoon, Match Book, Piggy Bank, Crack the Sky, 2Spooky, Sack of Sacks, Mom's Lipstick, Bum Friend, Fate's Reward, Booster Pack (Item), My Little Unicorn, Friend Zone, God's Flesh, Bomb Bag, Hypercoagulation, Midnight Snack, Pageant Boy, Friendly Ball, A Pound of Flesh, The Necronomicon, Teleport 2.0, Dull Razor, How to Jump, Thunder Thighs, Jaw Bone, Rotten Meat, Hushy, Vasculitis, Glass Cannon, Lil Haunt, Mom's Razor, Jupiter, Ventricle Razor, Mom's Box, Glaucoma, Potato Peeler, Converter, Esau Jr., Leo, Betrayal, Isaac's Tears, Little Gish, Supper, The Hourglass, Mystery Egg, Red Candle, Dinner, Mom's Wig, Cursed Eye, Headless Baby, Night Light, Isaac's Heart, Nancy Bombs, Pointy Rib, Mom's Coin Purse, Sharp Straw, Candy Heart, Guillotine, Missing Page 2, Heartbreak, Best Bud, Notched Axe, Bucket of Lard, Empty Heart, Ball of Tar, Pay to Play, Battery Pack, Dead Tooth, Linger Bean, Wavy Cap, Unicorn Stump, Keeper's Box, Undefined, The Gamekid, Bob's Brain, Lemon Mishap, Little Chubby, Mom's Bottle of Pills, Strawman, A Snack, Shade, E. Coli, Plan C, Friend Finder, Strange Attractor, Breath of Life, Dessert, Little Baggy, <3, D7, Dirty Mind, D8, Eye Sore, Milk!, Tinytoma, Punching Bag, Eraser, Samson's Chains, Sprinkler, Mom's Bracelet, Bird Cage, Key Bum, Delirious, Hemoptysis, Broken Watch, Infestation, Mine Crafter, Akeldama, Metronome, GB Bug, Poke Go, Scissors, Leprosy, Yuck Heart, The Pinking Shears, Mom's Underwear, Depression, Mr. Boom, Razor Blade, Slipped Rib, Blood Oath, It Hurts, Farting Baby, TMTRAINER, Angry Fly, Doctor's Remote, Teleport!, Dad's Note, Portable Slot, Flush!, Free Lemonade, Blood Rights, Key Piece 2, Spider Butt, Mom's Bra, The Wiz, Big Chubby, IBS, The Boomerang, Missing No., The Poop, Mom's Heels, Clicker, Forever Alone, Dead Sea Scrolls, Remote Detonator, Hold, Magneto, Wait What?, Lil Spewer, Marked, Best Friend, Tonsil, Mega Bean, Shard of Glass, Meat Cleaver, Brown Nugget, Bob's Rotten Head, The Bean, Mom's Shovel, Tear Detonator, Kamikaze!, Compost, Knife Piece 2, Blood Puppy, Dataminer, Anarchist Cookbook, Sharp Key, Spin to Win, The Jar, D10, Monstro's Tooth, Jar of Flies, Pause, The Scooper, D12, Keeper's Kin, Bumbo, Broken Glass Cannon, Broken Shovel, Golden Razor, Kidney Bean

F Tier

Knife Piece 1, Curse of the Tower, Butter Bean, The Black Bean, Mom's Pad