The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, Twisted Pair, Sacred Orb, Godhead, R Key, The D6, Holy Mantle, Mom's Knife, Spindown Dice, D Infinity, Tech X, Brimstone, Cricket's Head, Psy Fly, Incubus, Magic Mushroom, Mutant Spider, Crown of Light, Goat Head, Trisagion, A Lump of Coal, Jacob's Ladder, Red Key, Stop Watch, The Wafer, The Parasite, More Options, Rock Bottom, Pyromaniac, Ceremonial Robes, Revelation, Eternal D6, Birthright, Diplopia, Holy Light, Apple!, 20/20, Mega Mush, Athame, Succubus, The Stairway, Technology Zero, Polyphemus, Spoon Bender, Chaos, Flip, Pluto, Dead Eye, Binge Eater, Ghost Pepper, Cricket's Body, 8 Inch Nails, The Mark, Immaculate Heart, Technology, The Mind, Gnawed Leaf, Haemolacria, Host Hat, Eye of Belial, The Pact, Death's Touch, Fire Mind, Tractor Beam, Little Horn (Item), Mystery Gift, Steam Sale, Blood of the Martyr, Bird's Eye, Abaddon, Backstabber, Sausage, Lusty Blood, Tech.5, Rubber Cement, Head of the Keeper, Binky, Spirit Sword, Dark Matter, The Halo, Tough Love, SMB Super Fan, Black Candle, Bag of Crafting, Genesis, The Small Rock, Holy Grail, Ocular Rift, Money = Power, Book of Revelations, Technology 2, Growth Hormones

B Tier

Fruit Cake, Capricorn, Dead Cat, Pentagram, Eden's Blessing, Guppy's Eye, Dead Dove, Cat-O-Nine-Tails, Maw of the Void, Stigmata, Explosivo, Dogma (Item), Lemegeton, Rotten Baby, Eucharist, Star of Bethlehem, Lachryphagy, Guppy's Tail, Squeezy, Cancer, PJs, YO LISTEN!, Paschal Candle, Libra, Daddy Longlegs, Ipecac, Terra, The Battery, Soy Milk, Blue Map, Dark Arts, Red Stew, Fate, Book of Shadows, Mucormycosis, Wire Coat Hanger, Duality, Rosary, Book of Virtues, Monstro's Lung, Lost Contact, The Inner Eye, Placenta, Lodestone, Proptosis, Blanket, Car Battery, Knockout Drops, Saturnus, Tooth Picks, Forget Me Now, Damocles, Eve's Mascara, Voodoo Head, Lord of the Pit, Sulfur, Member Card, Satanic Bible, Toxic Shock, Purity, Sharp Plug, Mr. Dolly, Eye of the Occult, Mama Mega!, Blank Card, Humbleing Bundle, Dog Tooth, Uranus, Habit, Whore of Babylon, Sulfuric Acid, Mom's Contacts, Monstrance, Champion Belt, The Soul, A Dollar, Stapler, 9 Volt, Almond Milk, My Reflection, Sagittarius, Act of Contrition, Coupon, Roid Rage, Worm Friend, Lead Pencil, Gello, Odd Mushroom (Large), Spirit of the Night, Void, 4.5 Volt, The Sad Onion, Seraphim, Pyro, Scapular, Dark Bum, Infestation 2, Euthanasia, Angelic Prism, Guppy's Paw, Sacrificial Dagger, Synthoil, Restock, Mom's Key, X-Ray Vision, Gimpy, Continuum, Salvation, Spider Mod, Flat Stone, Jumper Cables, Sinus Infection, Blue Cap, We Need to Go Deeper!, Keeper's Sack, Epic Fetus, Bot Fly, Camo Undies, Sacrificial Altar, Tarot Cloth, Serpent's Kiss, 1up!, Guppy's Collar, Compound Fracture, Infamy, The Body, PHD, 7 Seals, Transcendence, Treasure Map, The Ludovico Technique, Lucky Foot, Scorpio, Options?, Dr. Fetus, Crystal Ball, Playdough Cookie, Contagion, Charm of the Vampire, Abyss, Lil Dumpy, Sack Head, Eden's Soul, Black Lotus, Mom's Pearls, Leech, Rune Bag, Ouija Board, Neptunus, Chocolate Milk, Trinity Shield, Parasitoid, There's Options, Dead Onion, BFFS!, Judas' Shadow, Charged Baby, The Intruder, Pisces, A Bar of Soap, Echo Chamber, Censer, Mitre, Blood Bag, Urn of Souls, Tropicamide, Marbles, Lil Abaddon, White Pony, 3 Dollar Bill, Eye Drops, Guppy's Head, Lil Brimstone, Freezer Baby, Mysterious Liquid, Mr. ME!, Cambion Conception, Torn Photo, Skeleton Key, Mini Mush, Bloody Lust, The Polaroid, Mega Blast, The Mulligan, Dad's Ring, Schoolbag, Multidimensional Baby, Odd Mushroom (Thin), Magic 8 Ball, Orphan Socks, Consolation Prize, Cupid's Arrow, The Relic, Speed Ball, Glass Eye, Divine Intervention, Virgo, Crooked Penny, Divorce Papers, Alabaster Box, Rotten Tomato, Jesus Juice, Mars, Fanny Pack

C Tier

False PHD, Magic Scab, Mom's Perfume, Yum Heart, Kidney Stone, Sissy Longlegs, Book of Secrets, Cube of Meat, Starter Deck, Pop!, Holy Water, A Pony, The Nail, Cone Head, Astral Projection, Analog Stick, Adrenaline, The Compass, The Book of Belial, Luna, Little Steven, Pupula Duplex, The Bible, Broken Modem, Dry Baby, Scatter Bombs, 120 Volt, Ghost Bombs, Chemical Peel, Screw, Tooth and Nail, MEAT!, Book of the Dead, Raw Liver, Maggy's Bow, Aquarius, Quints, Mom's Purse, Hungry Soul, Gemini (Item), Old Bandage, Everything Jar, D20, Contract From Below, Tiny Planet, Inner Child, Box of Friends, Metal Plate, Mom's Ring, Breakfast, Spelunker Hat, Montezuma's Revenge, Sticky Bombs, Soul Locket, Marrow, Glitter Bombs, Prayer Card, Brittle Bones, Black Hole, Big Fan, Telepathy for Dummies, Glyph of Balance, Midas' Touch, Iron Bar, Mom's Eye, Caffeine Pill, Hallowed Ground, Spider Bite, Papa Fly, Bozo, Mercurius, Deep Pockets, Empty Vessel, Sol, Dad's Lost Coin, Smelter, Steven (Item), Spear of Destiny, Immaculate Conception, Purgatory, Evil Charm, Taurus, Loki's Horns, No. 2, Ankh, D1, The Negative, The Candle, Azazel's Rage, Lil Loki, Card Reading, Anemic, Redemption, Smart Fly, Isaac's Tomb, Brother Bobby, Number One, Bogo Bombs, Greed's Gullet, Glowing Hourglass, Pandora's Box, Robo-Baby, Lunch, Lil Monstro, Suplex!, Cain's Other Eye, Epiphora, Bloody Gust, Rocket in a Jar, Acid Baby, Skatole, The Book of Sin, Dream Catcher, Bomber Boy, Dark Prince's Crown, Sad Bombs, Halo of Flies, The Common Cold, Boom!, Clear Rune, Anima Sola, Buddy in a Box, Evil Eye, Recall, Robo-Baby 2.0, Rainbow Baby, Lil Portal, D100, Sworn Protector, Shoop Da Whoop!, Mongo Baby, Magic Skin, Belly Button, Vanishing Twin, Stye, Boiled Baby, Death's List, Moving Box, Stitches, Sack of Pennies, Blood Clot, Butt Bombs, Guppy's Hair Ball, Larynx, Eye of Greed, Venus, Safety Pin, The Peeper, Zodiac, Stem Cells, Super Bandage, Little C.H.A.D., Monster Manual, Belly Jelly, Dad's Key, Spiderbaby, The Swarm, Berserk!, Box, Celtic Cross, Harlequin Baby, Hive Mind, ???'s Only Friend, Latch Key, Spirit Shackles, The Ladder, Blood Bombs, Brimstone Bombs, King Baby, A Quarter, Vengeful Spirit, My Shadow, Mr. Mega, Varicose Veins, Finger!, Circle of Protection, Mystery Sack, Fast Bombs, Plum Flute, Deck of Cards, Crack Jacks, Juicy Sack, Black Powder, Bobby-Bomb, Giant Cell, Distant Admiration, Lil Chest, Experimental Treatment, Cracked Orb, Ghost Baby, Box of Spiders, Vade Retro, Hot Bombs, Large Zit, Sumptorium, Lost Fly, Lazarus' Rags, Lil Delirium, Key Piece 1, Bone Spurs, Sister Maggy, Bob's Curse, Lost Soul, Wooden Nickel, Aries, Tammy's Head, D4, Obsessed Fan, Bloodshot Eye, The Virus, Telekinesis, Dead Bird, Fortune Cookie, Head of Krampus, BBF, Mom's Eyeshadow, Cube Baby, Fate's Reward, Match Book, Thunder Thighs, IV Bag

D Tier

Demon Baby, Placebo, Mom's Lipstick, Pageant Boy, Midnight Snack, The Belt, Sack of Sacks, Jar of Wisps, My Little Unicorn, Jaw Bone, Wooden Spoon, Polydactyly, Anti-Gravity, Vasculitis, A Pound of Flesh, Lil Gurdy, Teleport 2.0, 2Spooky, Ball of Bandages, Friend Zone, Guardian Angel, How to Jump, Bursting Sack, Booster Pack (Item), God's Flesh, Mystery Egg, Bum Friend, Esau Jr., Supper, Hypercoagulation, Abel, Betrayal, Lil Haunt, Sanguine Bond, Night Light, Decap Attack, Mom's Wig, Bomb Bag, Fruity Plum, The Hourglass, Jupiter, Rotten Meat, Glaucoma, Mom's Box, Ventricle Razor, Magic Fingers, Potato Peeler, Converter, Mom's Coin Purse, Red Candle, Piggy Bank, Crack the Sky, Isaac's Tears, Mom's Razor, Bob's Brain, Bucket of Lard, Ball of Tar, Empty Heart, Sharp Straw, Pay to Play, Leo, Dead Tooth, Hushy, Dull Razor, Glass Cannon, Key Bum, Best Bud, Headless Baby, Keeper's Box, Friendly Ball, Tinytoma, Little Baggy, Dinner, Little Gish, Breath of Life, Isaac's Heart, Guillotine, Notched Axe, Pointy Rib, A Snack, Unicorn Stump, E. Coli, Candy Heart, Dessert, Missing Page 2, Strange Attractor, Heartbreak, Mom's Bottle of Pills, Broken Watch, Undefined, Friend Finder, Infestation, Shade, Lemon Mishap, The Necronomicon, Milk!, Samson's Chains, Mom's Underwear, Blood Oath, Cursed Eye, D7, Akeldama, Dad's Note, Metronome, <3, Depression, Eye Sore, Eraser, Battery Pack, Sprinkler, Mom's Bracelet, Razor Blade, Wavy Cap, Strawman, Plan C, Yuck Heart, The Pinking Shears, Nancy Bombs, Dirty Mind, Scissors, Missing No., Mr. Boom, Blood Rights, GB Bug, Bird Cage, The Gamekid, Key Piece 2, Teleport!, Hemoptysis, Little Chubby, Free Lemonade, Portable Slot, Flush!, Doctor's Remote, Farting Baby, Poke Go, Delirious, Mom's Bra, Slipped Rib, Spider Butt, The Boomerang, TMTRAINER, Forever Alone, Linger Bean, It Hurts, Dead Sea Scrolls, D8, The Poop, Angry Fly, Punching Bag, Magneto, Leprosy, Marked, Clicker, Tonsil, Wait What?, Remote Detonator, Mine Crafter, Hold, Mom's Heels, Best Friend, IBS, Lil Spewer, Mega Bean, Mom's Shovel, Knife Piece 2, The Wiz, Meat Cleaver, Brown Nugget, The Bean, Bob's Rotten Head, Tear Detonator, Blood Puppy, Shard of Glass, Kamikaze!, Compost, Dataminer, Anarchist Cookbook, Sharp Key, Spin to Win, The Jar, D10, Big Chubby, Monstro's Tooth, Jar of Flies, Pause, The Scooper, Keeper's Kin, D12, Broken Glass Cannon, Golden Razor, Broken Shovel, Kidney Bean

F Tier

Curse of the Tower, Knife Piece 1, The Black Bean, Butter Bean, Bumbo, Mom's Pad