The Best Devil Room Items

A list of all devil room items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 66 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

95 Items

849 Votes

66 Voters

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1.Twisted Pair
1.Twisted Pair
Passive
Baby Shop
Quality 4
Devil Room
48
100
Rating
0.3
Spread
48
100
Rating
0.3
Spread

2.Mom's Knife
2.Mom's Knife
Passive
Treasure Room
Old Chest
Quality 4
Devil Room
50
100
Rating
0.3
Spread
50
100
Rating
0.3
Spread

3.Ceremonial Robes
3.Ceremonial Robes
Quality 3
Passive
Devil Beggar
Curse Room
Devil Room
3
99
Rating
3.2
Spread
3
99
Rating
3.2
Spread

4.Lemegeton
4.Lemegeton
Quality 3
Activated
Library
Devil Room
4
98
Rating
2
Spread
4
98
Rating
2
Spread

5.Little Horn (Item)
5.Little Horn (Item)
Quality 3
Passive
Devil Beggar
Curse Room
Devil Room
3
96
Rating
2.8
Spread
3
96
Rating
2.8
Spread

6.Goat Head
6.Goat Head
Quality 3
Passive
Curse Room
Red Chest
Devil Room
Golden Chest
6
96
Rating
2.7
Spread
6
96
Rating
2.7
Spread

7.Dark Arts
7.Dark Arts
Quality 2
Ultra Secret Room
Activated
Devil Room
5
91
Rating
3.5
Spread
5
91
Rating
3.5
Spread

8.Athame
8.Athame
Quality 3
Passive
Curse Room
Devil Room
3
89
Rating
6.8
Spread
3
89
Rating
6.8
Spread

9.Brimstone
9.Brimstone
Passive
Ultra Secret Room
Quality 4
Devil Room
48
85
Rating
0.5
Spread
48
85
Rating
0.5
Spread

10.Incubus
10.Incubus
Passive
Baby Shop
Quality 4
Devil Room
49
85
Rating
0.5
Spread
49
85
Rating
0.5
Spread

11.Guppy's Eye
11.Guppy's Eye
Quality 2
Passive
Curse Room
Red Chest
Devil Room
5
83
Rating
5.3
Spread
5
83
Rating
5.3
Spread

12.The Mark
12.The Mark
Quality 3
Passive
Ultra Secret Room
Devil Beggar
Curse Room
Devil Room
6
80
Rating
3.9
Spread
6
80
Rating
3.9
Spread

13.Abaddon
13.Abaddon
Quality 3
Passive
Ultra Secret Room
Devil Beggar
Devil Room
8
79
Rating
2.5
Spread
8
79
Rating
2.5
Spread

14.The Pact
14.The Pact
Quality 3
Passive
Ultra Secret Room
Devil Beggar
Curse Room
Devil Room
4
79
Rating
5.8
Spread
4
79
Rating
5.8
Spread

15.Dark Matter
15.Dark Matter
Quality 3
Passive
Devil Beggar
Devil Room
5
79
Rating
7.7
Spread
5
79
Rating
7.7
Spread

16.Eye of the Occult
16.Eye of the Occult
Quality 3
Passive
Ultra Secret Room
Devil Room
6
78
Rating
4.1
Spread
6
78
Rating
4.1
Spread

17.Gello
17.Gello
Quality 3
Ultra Secret Room
Treasure Room
Activated
Devil Room
4
78
Rating
3.8
Spread
4
78
Rating
3.8
Spread

18.Lusty Blood
18.Lusty Blood
Quality 3
Passive
Ultra Secret Room
Treasure Room
Devil Room
6
74
Rating
6.9
Spread
6
74
Rating
6.9
Spread

19.We Need to Go Deeper!
19.We Need to Go Deeper!
Quality 2
Secret Room
Activated
Devil Room
6
70
Rating
4.9
Spread
6
70
Rating
4.9
Spread

20.Damocles
20.Damocles
Quality 2
Activated
Devil Room
6
70
Rating
6.4
Spread
6
70
Rating
6.4
Spread

21.Death's Touch
21.Death's Touch
Quality 3
Passive
Treasure Room
Devil Room
7
68
Rating
6.3
Spread
7
68
Rating
6.3
Spread

22.Contract From Below
22.Contract From Below
Quality 3
Passive
Devil Beggar
Curse Room
Devil Room
5
67
Rating
6.2
Spread
5
67
Rating
6.2
Spread

23.Pentagram
23.Pentagram
Quality 3
Passive
Ultra Secret Room
Devil Beggar
Curse Room
Crane Game
Boss
Devil Room
6
66
Rating
4.4
Spread
6
66
Rating
4.4
Spread

24.Sulfur
24.Sulfur
Quality 3
Ultra Secret Room
Activated
Devil Room
5
65
Rating
6.9
Spread
5
65
Rating
6.9
Spread

25.Ocular Rift
25.Ocular Rift
Quality 3
Passive
Ultra Secret Room
Devil Room
5
63
Rating
8.1
Spread
5
63
Rating
8.1
Spread

26.Spirit of the Night
26.Spirit of the Night
Quality 3
Passive
Ultra Secret Room
Devil Beggar
Devil Room
5
63
Rating
6.7
Spread
5
63
Rating
6.7
Spread

27.The Book of Belial
27.The Book of Belial
Quality 2
Activated
Library
Devil Room
7
60
Rating
5.5
Spread
7
60
Rating
5.5
Spread

28.Book of the Dead
28.Book of the Dead
Quality 3
Treasure Room
Activated
Library
Devil Room
4
58
Rating
12.5
Spread
4
58
Rating
12.5
Spread

29.Guppy's Collar
29.Guppy's Collar
Passive
Quality 1
Curse Room
Crane Game
Red Chest
Devil Room
5
57
Rating
6.5
Spread
5
57
Rating
6.5
Spread

30.Rotten Baby
30.Rotten Baby
Quality 3
Passive
Baby Shop
Treasure Room
Devil Room
Rotten Beggar
5
57
Rating
4.7
Spread
5
57
Rating
4.7
Spread

31.Satanic Bible
31.Satanic Bible
Treasure Room
Quality 4
Activated
Library
Devil Room
45
56
Rating
0.9
Spread
45
56
Rating
0.9
Spread

32.Void
32.Void
Angel Room
Quality 4
Activated
Devil Room
47
56
Rating
0.8
Spread
47
56
Rating
0.8
Spread

33.Forget Me Now
33.Forget Me Now
Quality 3
Treasure Room
Secret Room
Activated
Devil Beggar
Devil Room
6
56
Rating
4.2
Spread
6
56
Rating
4.2
Spread

34.Azazel's Rage
34.Azazel's Rage
Quality 2
Passive
Devil Room
5
55
Rating
9.8
Spread
5
55
Rating
9.8
Spread

35.Dead Cat
35.Dead Cat
Quality 3
Passive
Curse Room
Red Chest
Devil Room
5
55
Rating
11.2
Spread
5
55
Rating
11.2
Spread

36.Whore of Babylon
36.Whore of Babylon
Quality 2
Passive
Ultra Secret Room
Devil Beggar
Devil Room
6
55
Rating
5.1
Spread
6
55
Rating
5.1
Spread

37.Eye of Belial
37.Eye of Belial
Quality 3
Passive
Ultra Secret Room
Devil Room
7
55
Rating
6
Spread
7
55
Rating
6
Spread

38.Cambion Conception
38.Cambion Conception
Quality 2
Passive
Ultra Secret Room
Devil Room
4
55
Rating
5.8
Spread
4
55
Rating
5.8
Spread

39.Lil Abaddon
39.Lil Abaddon
Quality 2
Passive
Baby Shop
Devil Room
6
54
Rating
7
Spread
6
54
Rating
7
Spread

40.Money = Power
40.Money = Power
Quality 3
Passive
Ultra Secret Room
Treasure Room
Devil Room
8
54
Rating
4.7
Spread
8
54
Rating
4.7
Spread

41.Maw of the Void
41.Maw of the Void
Quality 3
Passive
Ultra Secret Room
Devil Room
6
53
Rating
5.3
Spread
6
53
Rating
5.3
Spread

42.Gimpy
42.Gimpy
Quality 2
Passive
Treasure Room
Devil Beggar
Curse Room
Devil Room
6
53
Rating
6.6
Spread
6
53
Rating
6.6
Spread

43.My Shadow
43.My Shadow
Quality 2
Passive
Devil Room
4
52
Rating
10.1
Spread
4
52
Rating
10.1
Spread

44.Blood Rights
44.Blood Rights
Treasure Room
Quality 0
Activated
Devil Room
3
51
Rating
18.7
Spread
3
51
Rating
18.7
Spread

45.The Nail
45.The Nail
Quality 2
Activated
Devil Beggar
Devil Room
7
49
Rating
5.8
Spread
7
49
Rating
5.8
Spread

46.Guppy's Head
46.Guppy's Head
Quality 2
Activated
Curse Room
Red Chest
Devil Room
Golden Chest
4
49
Rating
12.3
Spread
4
49
Rating
12.3
Spread

47.Backstabber
47.Backstabber
Quality 3
Passive
Ultra Secret Room
Treasure Room
Devil Room
6
48
Rating
8.5
Spread
6
48
Rating
8.5
Spread

48.Mega Blast
48.Mega Blast
Quality 4
Activated
Devil Room
43
48
Rating
1.1
Spread
43
48
Rating
1.1
Spread

49.Succubus
49.Succubus
Quality 3
Passive
Baby Shop
Devil Beggar
Devil Room
4
47
Rating
5.4
Spread
4
47
Rating
5.4
Spread

50.Abyss
50.Abyss
Ultra Secret Room
Quality 4
Activated
Devil Room
49
46
Rating
0.8
Spread
49
46
Rating
0.8
Spread

51.Guppy's Tail
51.Guppy's Tail
Quality 2
Passive
Curse Room
Red Chest
Devil Room
6
45
Rating
6.2
Spread
6
45
Rating
6.2
Spread

52.7 Seals
52.7 Seals
Quality 2
Angel Room
Passive
Devil Room
8
44
Rating
4.7
Spread
8
44
Rating
4.7
Spread

53.Dark Bum
53.Dark Bum
Quality 3
Passive
Baby Shop
Treasure Room
Devil Beggar
Devil Room
6
43
Rating
7.1
Spread
6
43
Rating
7.1
Spread

54.Purgatory
54.Purgatory
Quality 2
Angel Room
Passive
Devil Room
4
43
Rating
6.8
Spread
4
43
Rating
6.8
Spread

55.Judas' Shadow
55.Judas' Shadow
Quality 3
Passive
Treasure Room
Devil Room
6
43
Rating
7.4
Spread
6
43
Rating
7.4
Spread

56.Empty Vessel
56.Empty Vessel
Quality 2
Passive
Devil Beggar
Devil Room
6
43
Rating
5.4
Spread
6
43
Rating
5.4
Spread

57.Brother Bobby
57.Brother Bobby
Passive
Quality 1
Baby Shop
Treasure Room
Devil Room
6
42
Rating
5.7
Spread
6
42
Rating
5.7
Spread

58.Bloody Lust
58.Bloody Lust
Quality 2
Passive
Ultra Secret Room
Treasure Room
Devil Room
9
41
Rating
2.5
Spread
9
41
Rating
2.5
Spread

59.Sacrificial Dagger
59.Sacrificial Dagger
Quality 2
Passive
Baby Shop
Treasure Room
Devil Room
5
39
Rating
4.3
Spread
5
39
Rating
4.3
Spread

60.Demon Baby
60.Demon Baby
Quality 2
Passive
Baby Shop
Treasure Room
Devil Beggar
Devil Room
6
39
Rating
6.1
Spread
6
39
Rating
6.1
Spread

61.Berserk!
61.Berserk!
Quality 2
Ultra Secret Room
Activated
Devil Room
3
38
Rating
12.3
Spread
3
38
Rating
12.3
Spread

62.Plan C
62.Plan C
Ultra Secret Room
Quality 0
Activated
Devil Beggar
Curse Room
Red Chest
Shop
Devil Room
7
38
Rating
6.9
Spread
7
38
Rating
6.9
Spread

63.Duality
63.Duality
Angel Room
Passive
Quality 1
Devil Room
5
36
Rating
4.8
Spread
5
36
Rating
4.8
Spread

64.Ouija Board
64.Ouija Board
Quality 2
Passive
Treasure Room
Devil Room
5
36
Rating
10.4
Spread
5
36
Rating
10.4
Spread

65.Lil Brimstone
65.Lil Brimstone
Quality 2
Passive
Baby Shop
Treasure Room
Devil Room
4
35
Rating
11.6
Spread
4
35
Rating
11.6
Spread

66.Guppy's Paw
66.Guppy's Paw
Quality 3
Activated
Curse Room
Red Chest
Devil Room
7
35
Rating
6
Spread
7
35
Rating
6
Spread

67.Multidimensional Baby
67.Multidimensional Baby
Quality 2
Passive
Treasure Room
Devil Room
6
33
Rating
2.8
Spread
6
33
Rating
2.8
Spread

68.A Pound of Flesh
68.A Pound of Flesh
Passive
Quality 1
Devil Beggar
Devil Room
6
33
Rating
3.8
Spread
6
33
Rating
3.8
Spread

69.Bloody Gust
69.Bloody Gust
Quality 2
Passive
Ultra Secret Room
Treasure Room
Devil Room
4
27
Rating
6
Spread
4
27
Rating
6
Spread

70.The Book of Sin
70.The Book of Sin
Quality 2
Treasure Room
Activated
Library
Devil Room
6
27
Rating
4.4
Spread
6
27
Rating
4.4
Spread

71.Heartbreak
71.Heartbreak
Quality 3
Passive
Ultra Secret Room
Curse Room
Devil Room
7
26
Rating
5.5
Spread
7
26
Rating
5.5
Spread

72.Dark Prince's Crown
72.Dark Prince's Crown
Passive
Quality 1
Curse Room
Devil Room
4
26
Rating
9.7
Spread
4
26
Rating
9.7
Spread

73.Razor Blade
73.Razor Blade
Treasure Room
Quality 0
Activated
Devil Beggar
Curse Room
Devil Room
5
25
Rating
8.8
Spread
5
25
Rating
8.8
Spread

74.Guppy's Hair Ball
74.Guppy's Hair Ball
Passive
Quality 1
Devil Room
6
24
Rating
6
Spread
6
24
Rating
6
Spread

75.Sacrificial Altar
75.Sacrificial Altar
Quality 2
Activated
Curse Room
Devil Room
3
23
Rating
13.7
Spread
3
23
Rating
13.7
Spread

76.Sanguine Bond
76.Sanguine Bond
Passive
Quality 1
Ultra Secret Room
Curse Room
Devil Room
7
23
Rating
3.3
Spread
7
23
Rating
3.3
Spread

77.Vengeful Spirit
77.Vengeful Spirit
Passive
Quality 1
Ultra Secret Room
Curse Room
Devil Room
4
22
Rating
4.9
Spread
4
22
Rating
4.9
Spread

78.Brimstone Bombs
78.Brimstone Bombs
Quality 2
Passive
Bomb Bum
Devil Room
7
21
Rating
3.4
Spread
7
21
Rating
3.4
Spread

79.Hungry Soul
79.Hungry Soul
Quality 2
Passive
Ultra Secret Room
Devil Room
3
21
Rating
8.1
Spread
3
21
Rating
8.1
Spread

80.Betrayal
80.Betrayal
Passive
Quality 1
Treasure Room
Devil Room
4
20
Rating
5.8
Spread
4
20
Rating
5.8
Spread

81.Blood Oath
81.Blood Oath
Passive
Quality 1
Curse Room
Devil Room
6
19
Rating
7.8
Spread
6
19
Rating
7.8
Spread

82.Lil Delirium
82.Lil Delirium
Quality 2
Angel Room
Passive
Baby Shop
Devil Room
4
19
Rating
6.3
Spread
4
19
Rating
6.3
Spread

83.Ghost Baby
83.Ghost Baby
Passive
Quality 1
Baby Shop
Treasure Room
Devil Room
4
18
Rating
6.4
Spread
4
18
Rating
6.4
Spread

84.Shade
84.Shade
Passive
Baby Shop
Quality 0
Curse Room
Devil Room
4
15
Rating
4.9
Spread
4
15
Rating
4.9
Spread

85.Monster Manual
85.Monster Manual
Quality 1
Treasure Room
Activated
Library
Devil Room
6
14
Rating
3
Spread
6
14
Rating
3
Spread

86.A Quarter
86.A Quarter
Passive
Treasure Room
Quality 0
Secret Room
Devil Room
Golden Chest
9
13
Rating
2
Spread
9
13
Rating
2
Spread

87.Death's List
87.Death's List
Quality 2
Passive
Devil Room
6
12
Rating
4.1
Spread
6
12
Rating
4.1
Spread

88.Lord of the Pit
88.Lord of the Pit
Quality 3
Passive
Ultra Secret Room
Devil Beggar
Devil Room
5
11
Rating
5.9
Spread
5
11
Rating
5.9
Spread

89.Missing Page 2
89.Missing Page 2
Passive
Quality 0
Secret Room
Devil Beggar
Devil Room
7
11
Rating
2.9
Spread
7
11
Rating
2.9
Spread

90.False PHD
90.False PHD
Quality 2
Passive
Ultra Secret Room
Curse Room
Red Chest
Devil Room
6
10
Rating
4.8
Spread
6
10
Rating
4.8
Spread

91.Sister Maggy
91.Sister Maggy
Passive
Quality 1
Ultra Secret Room
Baby Shop
Treasure Room
Devil Room
4
10
Rating
5.4
Spread
4
10
Rating
5.4
Spread

92.2Spooky
92.2Spooky
Passive
Quality 1
Ultra Secret Room
Devil Room
6
10
Rating
4.2
Spread
6
10
Rating
4.2
Spread

93.Headless Baby
93.Headless Baby
Passive
Quality 1
Baby Shop
Treasure Room
Devil Room
5
8
Rating
3
Spread
5
8
Rating
3
Spread

94.Black Powder
94.Black Powder
Passive
Quality 1
Devil Beggar
Devil Room
5
7
Rating
3
Spread
5
7
Rating
3
Spread

95.The Necronomicon
95.The Necronomicon
Quality 1
Secret Room
Activated
Library
Devil Room
7
0
Rating
1.3
Spread
7
0
Rating
1.3
Spread