A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 45 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.
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Red Key, Eternal D6
Chaos, Flip, Blank Card, Glitched Crown, Sausage, Death Certificate, Spindown Dice, Odd Mushroom (Large), Odd Mushroom (Thin), Rune Bag, Mr. Mega, Spirit Shackles
Infamy, Keeper's Box, Mystery Sack, Bomb Bag, Orphan Socks, Cracked Orb, Forget Me Now, We Need to Go Deeper!, D Infinity, R Key, Transcendence, Pyro
Dad's Ring, Skeleton Key, Inner Child, Eye of Greed, Greed's Gullet, Lost Soul, Isaac's Tomb, Keeper's Sack, Samson's Chains, Echo Chamber, Clear Rune, Sack of Sacks
Raw Liver, A Quarter, Sacred Orb, Book of Secrets, Black Lotus, Sack of Pennies, Epic Fetus, Mega Mush, 1up!, Missing Page 2, Sack Head
Key Bum, Wavy Cap, Binge Eater, The Necronomicon, Strawman, TMTRAINER, GB Bug
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