A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 30 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.
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Keeper's Box, Death Certificate
Sausage, Rock Bottom, R Key, Red Key, Rune Bag, Eternal D6, Forget Me Now, Infamy, Blank Card
Transcendence, Glitched Crown, Sacred Orb, Skeleton Key, Vanishing Twin, Clear Rune, Spindown Dice, Chaos, Echo Chamber, Odd Mushroom (Large), Orphan Socks, Book of Secrets, Keeper's Sack, We Need to Go Deeper!, 1up!, Pyro, Odd Mushroom (Thin), Mystery Sack, Placebo, D Infinity
A Quarter, Lost Contact, Eye of Greed, Sack of Sacks, Isaac's Tomb, Evil Charm, Raw Liver, Sack of Pennies, Lost Soul, Mega Mush, Dad's Ring, Flip, Epic Fetus
Black Lotus, Binge Eater, Bomb Bag, Mr. Mega, Spirit Shackles, Wavy Cap, Sack Head, Inner Child, Cracked Orb, Missing Page 2, Astral Projection, Samson's Chains, Strawman, Keeper's Kin, Greed's Gullet, The Necronomicon
TMTRAINER, Key Bum, Cursed Eye, GB Bug, Esau Jr., Compost
