The Best Secret Room Items Tier List

A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 60 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

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66 Items

673 Votes

60 Voters

Ranked List

Sort by

S

A

B

C

D

F

S Tier

Glitched Crown, Death Certificate

A Tier

Red Key, Sausage, Blank Card, Spindown Dice, Eternal D6, Odd Mushroom (Large), R Key

B Tier

Sacred Orb, Chaos, D Infinity, Rock Bottom, Orphan Socks, 1up!, Greed's Gullet, Rune Bag, Odd Mushroom (Thin), Bomb Bag, Dad's Ring, Raw Liver, Cracked Orb

C Tier

Pyro, Forget Me Now, Sack Head, Skeleton Key, Sack of Pennies, Infamy, Lost Contact, Vanishing Twin, Echo Chamber, Book of Secrets, Sack of Sacks, Mystery Sack, Lost Soul, Mega Mush, Mr. Mega, Cursed Eye, Placebo, Astral Projection, Flip, Spirit Shackles, A Quarter, Epic Fetus, Binge Eater

D Tier

Evil Charm, Transcendence, We Need to Go Deeper!, Isaac's Tomb, Esau Jr., Samson's Chains, Inner Child, Compost, Keeper's Box, Eye of Greed, Keeper's Sack, Clear Rune, Black Lotus