The Best Secret Room Items

A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 30 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

66 Items

328 Votes

30 Voters

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1.Keeper's Box
1.Keeper's Box
Quality 2
Secret Room
Activated
Wooden Chest
Shop
1
100
Rating
0
Spread
1
100
Rating
0
Spread

2.Death Certificate
2.Death Certificate
Secret Room
Quality 4
Activated
22
95
Rating
0.4
Spread
22
95
Rating
0.4
Spread

3.Sausage
3.Sausage
Quality 3
Passive
Secret Room
2
91
Rating
4.3
Spread
2
91
Rating
4.3
Spread

4.Rock Bottom
4.Rock Bottom
Quality 3
Passive
Secret Room
1
90
Rating
0
Spread
1
90
Rating
0
Spread

5.R Key
5.R Key
Secret Room
Quality 4
Activated
22
89
Rating
0.8
Spread
22
89
Rating
0.8
Spread

6.Red Key
6.Red Key
Quality 3
Ultra Secret Room
Secret Room
Activated
Key Master
Curse Room
Red Chest
1
87
Rating
0
Spread
1
87
Rating
0
Spread

7.Rune Bag
7.Rune Bag
Quality 3
Passive
Treasure Room
Secret Room
Golden Chest
1
84
Rating
0
Spread
1
84
Rating
0
Spread

8.Eternal D6
8.Eternal D6
Quality 3
Treasure Room
Secret Room
Activated
Crane Game
1
81
Rating
0
Spread
1
81
Rating
0
Spread

9.Forget Me Now
9.Forget Me Now
Quality 3
Treasure Room
Secret Room
Activated
Devil Beggar
Devil Room
2
76
Rating
2.4
Spread
2
76
Rating
2.4
Spread

10.Infamy
10.Infamy
Quality 2
Passive
Treasure Room
Secret Room
Golden Chest
4
76
Rating
1.9
Spread
4
76
Rating
1.9
Spread

11.Blank Card
11.Blank Card
Quality 2
Treasure Room
Secret Room
Activated
Shop
1
74
Rating
0
Spread
1
74
Rating
0
Spread

12.Transcendence
12.Transcendence
Quality 3
Passive
Secret Room
1
71
Rating
0
Spread
1
71
Rating
0
Spread

13.Glitched Crown
13.Glitched Crown
Passive
Secret Room
Quality 4
21
71
Rating
1.5
Spread
21
71
Rating
1.5
Spread

14.Sacred Orb
14.Sacred Orb
Angel Room
Passive
Secret Room
Quality 4
24
68
Rating
1.3
Spread
24
68
Rating
1.3
Spread

15.Skeleton Key
15.Skeleton Key
Quality 3
Passive
Treasure Room
Secret Room
3
66
Rating
1.6
Spread
3
66
Rating
1.6
Spread

16.Vanishing Twin
16.Vanishing Twin
Quality 2
Passive
Secret Room
Curse Room
1
65
Rating
0
Spread
1
65
Rating
0
Spread

16.Clear Rune
16.Clear Rune
Quality 2
Secret Room
Activated
Crane Game
1
65
Rating
0
Spread
1
65
Rating
0
Spread

18.Spindown Dice
18.Spindown Dice
Treasure Room
Secret Room
Quality 4
Activated
Crane Game
23
63
Rating
1.2
Spread
23
63
Rating
1.2
Spread

19.Chaos
19.Chaos
Quality 3
Passive
Secret Room
Shop
3
63
Rating
11.5
Spread
3
63
Rating
11.5
Spread

20.Echo Chamber
20.Echo Chamber
Quality 3
Passive
Ultra Secret Room
Secret Room
1
61
Rating
0
Spread
1
61
Rating
0
Spread

21.Odd Mushroom (Large)
21.Odd Mushroom (Large)
Quality 2
Passive
Treasure Room
Secret Room
3
60
Rating
11.4
Spread
3
60
Rating
11.4
Spread

22.Orphan Socks
22.Orphan Socks
Quality 2
Passive
Secret Room
Golden Chest
3
60
Rating
5.5
Spread
3
60
Rating
5.5
Spread

23.Book of Secrets
23.Book of Secrets
Quality 1
Treasure Room
Secret Room
Activated
Library
1
58
Rating
0
Spread
1
58
Rating
0
Spread

24.Keeper's Sack
24.Keeper's Sack
Quality 3
Passive
Secret Room
Shop
2
56
Rating
1.3
Spread
2
56
Rating
1.3
Spread

25.We Need to Go Deeper!
25.We Need to Go Deeper!
Quality 2
Secret Room
Activated
Devil Room
1
55
Rating
0
Spread
1
55
Rating
0
Spread

26.1up!
26.1up!
Quality 2
Passive
Secret Room
1
53
Rating
0
Spread
1
53
Rating
0
Spread

27.Pyro
27.Pyro
Quality 3
Passive
Treasure Room
Secret Room
Bomb Bum
4
53
Rating
4.6
Spread
4
53
Rating
4.6
Spread

28.Odd Mushroom (Thin)
28.Odd Mushroom (Thin)
Quality 2
Passive
Treasure Room
Secret Room
3
52
Rating
15.1
Spread
3
52
Rating
15.1
Spread

29.Mystery Sack
29.Mystery Sack
Quality 2
Passive
Treasure Room
Beggar
Secret Room
Golden Chest
3
52
Rating
5.3
Spread
3
52
Rating
5.3
Spread

30.Placebo
30.Placebo
Quality 2
Secret Room
Activated
Shop
1
52
Rating
0
Spread
1
52
Rating
0
Spread

31.D Infinity
31.D Infinity
Treasure Room
Secret Room
Quality 4
Activated
25
51
Rating
1.1
Spread
25
51
Rating
1.1
Spread

32.A Quarter
32.A Quarter
Passive
Treasure Room
Quality 0
Secret Room
Devil Room
Golden Chest
3
50
Rating
11.3
Spread
3
50
Rating
11.3
Spread

33.Lost Contact
33.Lost Contact
Quality 2
Passive
Treasure Room
Secret Room
1
48
Rating
0
Spread
1
48
Rating
0
Spread

34.Eye of Greed
34.Eye of Greed
Quality 2
Passive
Secret Room
2
48
Rating
12.9
Spread
2
48
Rating
12.9
Spread

35.Sack of Sacks
35.Sack of Sacks
Quality 3
Passive
Secret Room
Shop
Golden Chest
2
46
Rating
0.5
Spread
2
46
Rating
0.5
Spread

36.Isaac's Tomb
36.Isaac's Tomb
Quality 3
Passive
Secret Room
3
43
Rating
6.7
Spread
3
43
Rating
6.7
Spread

37.Evil Charm
37.Evil Charm
Quality 2
Passive
Secret Room
1
42
Rating
0
Spread
1
42
Rating
0
Spread

38.Raw Liver
38.Raw Liver
Quality 2
Passive
Secret Room
2
39
Rating
6.9
Spread
2
39
Rating
6.9
Spread

39.Sack of Pennies
39.Sack of Pennies
Passive
Quality 1
Treasure Room
Secret Room
Golden Chest
1
39
Rating
0
Spread
1
39
Rating
0
Spread

40.Lost Soul
40.Lost Soul
Quality 2
Passive
Baby Shop
Treasure Room
Secret Room
2
39
Rating
13.7
Spread
2
39
Rating
13.7
Spread

41.Mega Mush
41.Mega Mush
Treasure Room
Secret Room
Quality 4
Activated
25
37
Rating
1.1
Spread
25
37
Rating
1.1
Spread

42.Dad's Ring
42.Dad's Ring
Quality 3
Passive
Old Chest
Secret Room
3
33
Rating
12
Spread
3
33
Rating
12
Spread

43.Flip
43.Flip
Ultra Secret Room
Secret Room
Quality 4
Activated
Curse Room
22
33
Rating
1.5
Spread
22
33
Rating
1.5
Spread

44.Epic Fetus
44.Epic Fetus
Passive
Treasure Room
Secret Room
Quality 4
21
31
Rating
1.5
Spread
21
31
Rating
1.5
Spread

45.Black Lotus
45.Black Lotus
Quality 2
Passive
Secret Room
2
27
Rating
4.4
Spread
2
27
Rating
4.4
Spread

46.Binge Eater
46.Binge Eater
Passive
Secret Room
Quality 4
22
27
Rating
1.3
Spread
22
27
Rating
1.3
Spread

47.Bomb Bag
47.Bomb Bag
Quality 2
Passive
Treasure Room
Secret Room
Bomb Bum
Golden Chest
1
21
Rating
0
Spread
1
21
Rating
0
Spread

48.Mr. Mega
48.Mr. Mega
Quality 2
Passive
Treasure Room
Secret Room
Bomb Bum
2
21
Rating
5.8
Spread
2
21
Rating
5.8
Spread

49.Spirit Shackles
49.Spirit Shackles
Quality 2
Passive
Secret Room
1
17
Rating
0
Spread
1
17
Rating
0
Spread

50.Wavy Cap
50.Wavy Cap
Quality 1
Secret Room
Activated
2
16
Rating
11.4
Spread
2
16
Rating
11.4
Spread

51.Sack Head
51.Sack Head
Quality 3
Passive
Secret Room
Shop
2
14
Rating
21.5
Spread
2
14
Rating
21.5
Spread

52.Inner Child
52.Inner Child
Quality 2
Passive
Secret Room
2
13
Rating
17.1
Spread
2
13
Rating
17.1
Spread

53.Cracked Orb
53.Cracked Orb
Passive
Quality 1
Treasure Room
Secret Room
2
13
Rating
2.8
Spread
2
13
Rating
2.8
Spread

54.Missing Page 2
54.Missing Page 2
Passive
Quality 0
Secret Room
Devil Beggar
Devil Room
2
13
Rating
6.9
Spread
2
13
Rating
6.9
Spread

55.Astral Projection
55.Astral Projection
Quality 2
Passive
Treasure Room
Secret Room
1
13
Rating
0
Spread
1
13
Rating
0
Spread

56.Samson's Chains
56.Samson's Chains
Passive
Quality 1
Treasure Room
Secret Room
3
11
Rating
1.1
Spread
3
11
Rating
1.1
Spread

57.Strawman
57.Strawman
Quality 2
Passive
Secret Room
2
10
Rating
3.1
Spread
2
10
Rating
3.1
Spread

58.Keeper's Kin
58.Keeper's Kin
Quality 2
Passive
Treasure Room
Secret Room
1
8
Rating
0
Spread
1
8
Rating
0
Spread

58.Greed's Gullet
58.Greed's Gullet
Passive
Quality 1
Secret Room
1
8
Rating
0
Spread
1
8
Rating
0
Spread

60.The Necronomicon
60.The Necronomicon
Quality 1
Secret Room
Activated
Library
Devil Room
2
7
Rating
2.1
Spread
2
7
Rating
2.1
Spread

61.TMTRAINER
61.TMTRAINER
Passive
Quality 0
Secret Room
2
6
Rating
2.5
Spread
2
6
Rating
2.5
Spread

62.Key Bum
62.Key Bum
Passive
Baby Shop
Treasure Room
Quality 0
Secret Room
Key Master
2
6
Rating
2.6
Spread
2
6
Rating
2.6
Spread

63.Cursed Eye
63.Cursed Eye
Passive
Treasure Room
Quality 0
Secret Room
Red Chest
1
0
Rating
0
Spread
1
0
Rating
0
Spread

63.GB Bug
63.GB Bug
Passive
Quality 1
Treasure Room
Secret Room
2
0
Rating
0
Spread
2
0
Rating
0
Spread

63.Esau Jr.
63.Esau Jr.
Quality 2
Ultra Secret Room
Treasure Room
Secret Room
Activated
1
0
Rating
0
Spread
1
0
Rating
0
Spread

63.Compost
63.Compost
Quality 1
Secret Room
Activated
Shop
Rotten Beggar
1
0
Rating
0
Spread
1
0
Rating
0
Spread