The Best Secret Room Items

A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst. We combined votes from 45 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

56 Items

455 Votes

45 Voters

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1.Red Key
1.Red Key
Quality 3
Ultra Secret Room
Secret Room
Activated
Key Master
Curse Room
Red Chest
2
100
Rating
0
Spread
2
100
Rating
0
Spread

2.Eternal D6
2.Eternal D6
Quality 3
Treasure Room
Secret Room
Activated
Crane Game
2
97
Rating
2.9
Spread
2
97
Rating
2.9
Spread

3.Chaos
3.Chaos
Quality 3
Passive
Secret Room
Shop
4
95
Rating
1.3
Spread
4
95
Rating
1.3
Spread

4.Flip
4.Flip
Ultra Secret Room
Secret Room
Quality 4
Activated
Curse Room
30
93
Rating
0.5
Spread
30
93
Rating
0.5
Spread

5.Blank Card
5.Blank Card
Quality 2
Treasure Room
Secret Room
Activated
Shop
2
88
Rating
14.2
Spread
2
88
Rating
14.2
Spread

6.Glitched Crown
6.Glitched Crown
Passive
Secret Room
Quality 4
31
86
Rating
0.3
Spread
31
86
Rating
0.3
Spread

7.Sausage
7.Sausage
Quality 3
Passive
Secret Room
3
85
Rating
7.8
Spread
3
85
Rating
7.8
Spread

8.Death Certificate
8.Death Certificate
Secret Room
Quality 4
Activated
32
85
Rating
0.3
Spread
32
85
Rating
0.3
Spread

9.Spindown Dice
9.Spindown Dice
Treasure Room
Secret Room
Quality 4
Activated
Crane Game
32
83
Rating
0.3
Spread
32
83
Rating
0.3
Spread

10.Odd Mushroom (Large)
10.Odd Mushroom (Large)
Quality 2
Passive
Treasure Room
Secret Room
3
78
Rating
13.2
Spread
3
78
Rating
13.2
Spread

11.Odd Mushroom (Thin)
11.Odd Mushroom (Thin)
Quality 2
Passive
Treasure Room
Secret Room
3
75
Rating
3.6
Spread
3
75
Rating
3.6
Spread

12.Rune Bag
12.Rune Bag
Quality 3
Passive
Treasure Room
Secret Room
Golden Chest
2
75
Rating
14.4
Spread
2
75
Rating
14.4
Spread

13.Mr. Mega
13.Mr. Mega
Quality 2
Passive
Treasure Room
Secret Room
Bomb Bum
2
75
Rating
12.2
Spread
2
75
Rating
12.2
Spread

14.Spirit Shackles
14.Spirit Shackles
Quality 2
Passive
Secret Room
2
73
Rating
7
Spread
2
73
Rating
7
Spread

15.Infamy
15.Infamy
Quality 2
Passive
Treasure Room
Secret Room
Golden Chest
4
73
Rating
6.8
Spread
4
73
Rating
6.8
Spread

16.Keeper's Box
16.Keeper's Box
Quality 2
Secret Room
Activated
Wooden Chest
Shop
3
70
Rating
17.1
Spread
3
70
Rating
17.1
Spread

17.Mystery Sack
17.Mystery Sack
Quality 2
Passive
Treasure Room
Beggar
Secret Room
Golden Chest
4
70
Rating
6
Spread
4
70
Rating
6
Spread

18.Bomb Bag
18.Bomb Bag
Quality 2
Passive
Treasure Room
Secret Room
Bomb Bum
Golden Chest
3
67
Rating
10.5
Spread
3
67
Rating
10.5
Spread

19.Orphan Socks
19.Orphan Socks
Quality 2
Passive
Secret Room
Golden Chest
4
64
Rating
7.9
Spread
4
64
Rating
7.9
Spread

20.Cracked Orb
20.Cracked Orb
Passive
Quality 1
Treasure Room
Secret Room
3
63
Rating
3.9
Spread
3
63
Rating
3.9
Spread

21.Forget Me Now
21.Forget Me Now
Quality 3
Treasure Room
Secret Room
Activated
Devil Beggar
Devil Room
4
61
Rating
3.8
Spread
4
61
Rating
3.8
Spread

22.We Need to Go Deeper!
22.We Need to Go Deeper!
Quality 2
Secret Room
Activated
Devil Room
3
57
Rating
3.9
Spread
3
57
Rating
3.9
Spread

23.D Infinity
23.D Infinity
Treasure Room
Secret Room
Quality 4
Activated
33
56
Rating
0.3
Spread
33
56
Rating
0.3
Spread

24.R Key
24.R Key
Secret Room
Quality 4
Activated
33
55
Rating
0.4
Spread
33
55
Rating
0.4
Spread

25.Transcendence
25.Transcendence
Quality 3
Passive
Secret Room
3
54
Rating
6.6
Spread
3
54
Rating
6.6
Spread

26.Pyro
26.Pyro
Quality 3
Passive
Treasure Room
Secret Room
Bomb Bum
4
52
Rating
5.2
Spread
4
52
Rating
5.2
Spread

27.Dad's Ring
27.Dad's Ring
Quality 3
Passive
Old Chest
Secret Room
3
45
Rating
4.9
Spread
3
45
Rating
4.9
Spread

28.Skeleton Key
28.Skeleton Key
Quality 3
Passive
Treasure Room
Secret Room
3
40
Rating
7.5
Spread
3
40
Rating
7.5
Spread

29.Inner Child
29.Inner Child
Quality 2
Passive
Secret Room
2
39
Rating
9.2
Spread
2
39
Rating
9.2
Spread

30.Eye of Greed
30.Eye of Greed
Quality 2
Passive
Secret Room
2
38
Rating
15.2
Spread
2
38
Rating
15.2
Spread

31.Greed's Gullet
31.Greed's Gullet
Passive
Quality 1
Secret Room
3
37
Rating
6
Spread
3
37
Rating
6
Spread

32.Lost Soul
32.Lost Soul
Quality 2
Passive
Baby Shop
Treasure Room
Secret Room
2
37
Rating
10.6
Spread
2
37
Rating
10.6
Spread

33.Isaac's Tomb
33.Isaac's Tomb
Quality 3
Passive
Secret Room
3
36
Rating
18.8
Spread
3
36
Rating
18.8
Spread

34.Keeper's Sack
34.Keeper's Sack
Quality 3
Passive
Secret Room
Shop
3
35
Rating
9.9
Spread
3
35
Rating
9.9
Spread

35.Samson's Chains
35.Samson's Chains
Passive
Quality 1
Treasure Room
Secret Room
5
34
Rating
5
Spread
5
34
Rating
5
Spread

36.Echo Chamber
36.Echo Chamber
Quality 3
Passive
Ultra Secret Room
Secret Room
2
32
Rating
6.2
Spread
2
32
Rating
6.2
Spread

37.Clear Rune
37.Clear Rune
Quality 2
Secret Room
Activated
Crane Game
2
30
Rating
8.4
Spread
2
30
Rating
8.4
Spread

38.Sack of Sacks
38.Sack of Sacks
Quality 3
Passive
Secret Room
Shop
Golden Chest
4
29
Rating
5
Spread
4
29
Rating
5
Spread

39.Raw Liver
39.Raw Liver
Quality 2
Passive
Secret Room
2
29
Rating
11.8
Spread
2
29
Rating
11.8
Spread

40.A Quarter
40.A Quarter
Passive
Treasure Room
Quality 0
Secret Room
Devil Room
Golden Chest
7
28
Rating
4
Spread
7
28
Rating
4
Spread

41.Sacred Orb
41.Sacred Orb
Angel Room
Passive
Secret Room
Quality 4
34
27
Rating
0.6
Spread
34
27
Rating
0.6
Spread

42.Book of Secrets
42.Book of Secrets
Quality 1
Treasure Room
Secret Room
Activated
Library
2
25
Rating
1.1
Spread
2
25
Rating
1.1
Spread

43.Black Lotus
43.Black Lotus
Quality 2
Passive
Secret Room
3
23
Rating
9.7
Spread
3
23
Rating
9.7
Spread

44.Sack of Pennies
44.Sack of Pennies
Passive
Quality 1
Treasure Room
Secret Room
Golden Chest
2
23
Rating
5.2
Spread
2
23
Rating
5.2
Spread

45.Epic Fetus
45.Epic Fetus
Passive
Treasure Room
Secret Room
Quality 4
30
23
Rating
0.6
Spread
30
23
Rating
0.6
Spread

46.Mega Mush
46.Mega Mush
Treasure Room
Secret Room
Quality 4
Activated
34
23
Rating
0.5
Spread
34
23
Rating
0.5
Spread

47.1up!
47.1up!
Quality 2
Passive
Secret Room
2
17
Rating
5.2
Spread
2
17
Rating
5.2
Spread

48.Missing Page 2
48.Missing Page 2
Passive
Quality 0
Secret Room
Devil Beggar
Devil Room
5
13
Rating
5.9
Spread
5
13
Rating
5.9
Spread

49.Sack Head
49.Sack Head
Quality 3
Passive
Secret Room
Shop
2
7
Rating
18.3
Spread
2
7
Rating
18.3
Spread

50.Key Bum
50.Key Bum
Passive
Baby Shop
Treasure Room
Quality 0
Secret Room
Key Master
2
5
Rating
1.6
Spread
2
5
Rating
1.6
Spread

51.Wavy Cap
51.Wavy Cap
Quality 1
Secret Room
Activated
3
5
Rating
2.5
Spread
3
5
Rating
2.5
Spread

52.Binge Eater
52.Binge Eater
Passive
Secret Room
Quality 4
31
5
Rating
0.4
Spread
31
5
Rating
0.4
Spread

53.The Necronomicon
53.The Necronomicon
Quality 1
Secret Room
Activated
Library
Devil Room
4
4
Rating
1.1
Spread
4
4
Rating
1.1
Spread

54.Strawman
54.Strawman
Quality 2
Passive
Secret Room
3
3
Rating
0.9
Spread
3
3
Rating
0.9
Spread

55.TMTRAINER
55.TMTRAINER
Passive
Quality 0
Secret Room
2
2
Rating
2.4
Spread
2
2
Rating
2.4
Spread

56.GB Bug
56.GB Bug
Passive
Quality 1
Treasure Room
Secret Room
2
0
Rating
5.7
Spread
2
0
Rating
5.7
Spread