The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, Twisted Pair, Godhead, Sacred Orb, R Key, The D6, Holy Mantle, Mom's Knife, Spindown Dice, D Infinity, Tech X, Brimstone, Cricket's Head, Psy Fly, Incubus, Magic Mushroom, Mutant Spider, Jacob's Ladder, Goat Head, Crown of Light, Trisagion, A Lump of Coal, Red Key, Stop Watch, The Parasite, The Wafer, More Options, Rock Bottom, Apple!, Pyromaniac, Ceremonial Robes, Diplopia, Athame, Eternal D6, Revelation, Holy Light, Birthright, Technology Zero, Succubus, Cricket's Body, 20/20, Mega Mush, Chaos, The Stairway, Pluto, Spoon Bender, Dead Eye, Polyphemus, Binge Eater, Flip, 8 Inch Nails, Ghost Pepper, The Mark, Gnawed Leaf, Host Hat, Fire Mind, Technology, Immaculate Heart, Little Horn (Item), The Mind, Mystery Gift, Haemolacria, The Pact, Blood of the Martyr, Eye of Belial, Steam Sale, Death's Touch, Bag of Crafting, Abaddon, Rubber Cement, Dark Matter, Bird's Eye, Binky, Head of the Keeper, Backstabber, Tractor Beam, Money = Power, Sausage, Lusty Blood, Tough Love, Ocular Rift, Spirit Sword, Explosivo, Soy Milk, The Small Rock, The Halo, SMB Super Fan, Tech.5, Eden's Blessing, Black Candle, Holy Grail, Stigmata, Growth Hormones

B Tier

Technology 2, Pentagram, Duality, Genesis, Cat-O-Nine-Tails, Daddy Longlegs, Guppy's Tail, Lemegeton, The Battery, Capricorn, Book of Revelations, Rotten Baby, Dead Dove, Guppy's Eye, Knockout Drops, Dead Cat, Fruit Cake, Maw of the Void, Eucharist, Squeezy, Damocles, Monstro's Lung, Tooth Picks, Paschal Candle, Book of Virtues, Dogma (Item), Lachryphagy, Wire Coat Hanger, Almond Milk, Eve's Mascara, Rosary, PJs, Placenta, Cancer, Blue Map, YO LISTEN!, Star of Bethlehem, Champion Belt, Fate, Red Stew, Uranus, Member Card, Lodestone, Lost Contact, Ipecac, Dark Arts, Terra, Mucormycosis, Voodoo Head, Car Battery, Blanket, Mama Mega!, Libra, Forget Me Now, Sharp Plug, Book of Shadows, Lord of the Pit, 4.5 Volt, Purity, Toxic Shock, The Soul, Sulfur, Blank Card, Angelic Prism, Coupon, The Inner Eye, Proptosis, Saturnus, Restock, Mom's Contacts, Spider Mod, The Sad Onion, Stapler, Monstrance, Sacrificial Altar, Habit, The Ludovico Technique, Satanic Bible, Roid Rage, Euthanasia, Mr. Dolly, Humbleing Bundle, 9 Volt, Dog Tooth, Sulfuric Acid, Whore of Babylon, Lead Pencil, Eye of the Occult, Sagittarius, A Dollar, Playdough Cookie, Worm Friend, Act of Contrition, Mom's Pearls, Continuum, Scapular, Sacrificial Dagger, Void, Treasure Map, My Reflection, 7 Seals, Odd Mushroom (Large), Gello, Spirit of the Night, Jumper Cables, Bot Fly, Infamy, 1up!, Flat Stone, Tarot Cloth, Guppy's Collar, Infestation 2, Neptunus, Serpent's Kiss, Salvation, Pisces, Sinus Infection, Blue Cap, Contagion, BFFS!, Freezer Baby, Mom's Key, Gimpy, Eden's Soul, Pyro, We Need to Go Deeper!, Leech, Tropicamide, Dark Bum, Trinity Shield, Guppy's Paw, Chocolate Milk, Synthoil, Compound Fracture, Charged Baby, Charm of the Vampire, Seraphim, A Bar of Soap, Scorpio, The Body, X-Ray Vision, Ouija Board, There's Options, Abyss, Keeper's Sack, Epic Fetus, PHD, Sack Head, Dr. Fetus, Censer, Alabaster Box, Black Lotus, White Pony, 3 Dollar Bill, Lucky Foot, Marbles, Astral Projection, Transcendence, Mysterious Liquid, Eye Drops, Dead Onion, Options?, The Intruder, Camo Undies, Torn Photo, Guppy's Head, Rune Bag, Blood Bag, Lil Dumpy, Mitre, Crystal Ball, Schoolbag, Speed Ball, Lil Abaddon, Rotten Tomato, Cambion Conception, Skeleton Key, Mom's Perfume, Lil Brimstone, Echo Chamber, Mr. ME!, Parasitoid, Urn of Souls, The Nail, Bloody Lust, Magic 8 Ball, Judas' Shadow, The Mulligan, Cube of Meat, Consolation Prize, Cupid's Arrow, Dad's Ring, Fanny Pack, Pop!, Sissy Longlegs, Mini Mush, Book of Secrets, Divine Intervention, Mega Blast, Odd Mushroom (Thin), Adrenaline, Multidimensional Baby, Jesus Juice, Glass Eye, Magic Scab, Yum Heart, The Bible, Analog Stick

C Tier

Pupula Duplex, The Polaroid, The Book of Belial, Crooked Penny, D20, Orphan Socks, Mom's Purse, Quints, Book of the Dead, Mars, Smelter, Divorce Papers, 120 Volt, Papa Fly, Box of Friends, Gemini (Item), The Relic, Scatter Bombs, False PHD, Virgo, Kidney Stone, Cone Head, Holy Water, A Pony, Mom's Eye, Dry Baby, Aquarius, Ghost Bombs, Tiny Planet, Screw, Metal Plate, Iron Bar, Tooth and Nail, Chemical Peel, Midas' Touch, MEAT!, Spider Bite, Hallowed Ground, Starter Deck, Black Hole, Azazel's Rage, Old Bandage, Deep Pockets, Loki's Horns, Little Steven, Big Fan, Luna, Caffeine Pill, Contract From Below, Montezuma's Revenge, The Compass, Glitter Bombs, Hungry Soul, Sticky Bombs, Dad's Lost Coin, Taurus, The Common Cold, Maggy's Bow, Raw Liver, Spear of Destiny, Broken Modem, Mom's Ring, Purgatory, Greed's Gullet, Skatole, Bozo, Redemption, Suplex!, Vanishing Twin, Marrow, Spelunker Hat, Smart Fly, Lil Portal, Immaculate Conception, Magic Skin, Soul Locket, Rainbow Baby, Boom!, Brother Bobby, Buddy in a Box, Evil Charm, Telepathy for Dummies, Lil Monstro, Prayer Card, Lil Loki, Empty Vessel, The Book of Sin, Anemic, Ankh, Moving Box, Card Reading, Inner Child, Guppy's Hair Ball, Bogo Bombs, Safety Pin, Evil Eye, Lunch, Belly Button, Zodiac, D1, Brittle Bones, Larynx, Isaac's Tomb, Rocket in a Jar, Acid Baby, Number One, Spiderbaby, Glyph of Balance, Mercurius, Breakfast, Eye of Greed, Dark Prince's Crown, Bomber Boy, Harlequin Baby, The Negative, Cain's Other Eye, No. 2, Spirit Shackles, The Swarm, Monster Manual, Robo-Baby, Blood Clot, Varicose Veins, Hive Mind, Halo of Flies, Sol, Pandora's Box, Shoop Da Whoop!, Sack of Pennies, Stitches, The Candle, Steven (Item), Anima Sola, D100, Butt Bombs, Distant Admiration, Everything Jar, Mongo Baby, Stem Cells, Plum Flute, The Ladder, Dad's Key, Epiphora, Clear Rune, Tammy's Head, ???'s Only Friend, Glowing Hourglass, King Baby, Bloody Gust, Robo-Baby 2.0, Stye, Box of Spiders, Dream Catcher, The Peeper, Sworn Protector, Giant Cell, Latch Key, Boiled Baby, Berserk!, Death's List, BBF, Mystery Sack, Large Zit, Black Powder, Finger!, Box, Little C.H.A.D., Super Bandage, Venus, Vengeful Spirit, Celtic Cross, Vade Retro, Mr. Mega, Cracked Orb, Experimental Treatment, Thunder Thighs, A Quarter, Dead Bird, Ghost Baby, Sad Bombs, Circle of Protection, Juicy Sack, My Shadow, Lil Gurdy, Cube Baby, Wooden Nickel, Bloodshot Eye, Blood Bombs, Fast Bombs, Jar of Wisps, Sister Maggy, Lost Soul, Head of Krampus, Mom's Eyeshadow, The Virus, Aries, Recall, Brimstone Bombs, Lil Chest, Placebo, Belly Jelly, Lil Haunt, Sumptorium, Key Piece 1, Obsessed Fan, Lil Delirium, Bob's Curse, Fate's Reward, Fortune Cookie, Jaw Bone, A Pound of Flesh, Bone Spurs, Hot Bombs, Sack of Sacks, Bobby-Bomb, D4, Polydactyly, The Belt, 2Spooky, Wooden Spoon, Vasculitis, Match Book, Night Light, Midnight Snack

D Tier

Mom's Lipstick, Betrayal, Telekinesis, Ball of Bandages, Crack Jacks, Bursting Sack, Mystery Egg, Demon Baby, Bum Friend, Glaucoma, My Little Unicorn, Fruity Plum, How to Jump, Isaac's Tears, Decap Attack, Deck of Cards, Pageant Boy, Friendly Ball, Lost Fly, Friend Zone, Lazarus' Rags, Best Bud, Guardian Angel, Mom's Wig, Abel, Leo, Glass Cannon, Supper, Potato Peeler, Crack the Sky, Dead Tooth, Hypercoagulation, Key Bum, Little Baggy, Rotten Meat, Hushy, Mom's Box, Ball of Tar, Keeper's Box, Jupiter, Empty Heart, Magic Fingers, Sharp Straw, Strange Attractor, Broken Watch, The Hourglass, Lemon Mishap, E. Coli, Mom's Razor, Infestation, Pointy Rib, Headless Baby, Booster Pack (Item), Sanguine Bond, Pay to Play, Bob's Brain, Ventricle Razor, Shade, Little Gish, Esau Jr., Metronome, D8, Candy Heart, Dull Razor, Bucket of Lard, Bomb Bag, Converter, Mom's Bottle of Pills, Tinytoma, Dad's Note, Eye Sore, Teleport 2.0, Anti-Gravity, Piggy Bank, Cursed Eye, D7, Wavy Cap, Mom's Underwear, Undefined, Akeldama, Missing Page 2, Missing No., God's Flesh, Eraser, Guillotine, IV Bag, Mom's Bracelet, Samson's Chains, Mom's Coin Purse, Depression, Plan C, Dinner, Sprinkler, Scissors, Razor Blade, Red Candle, A Snack, Dessert, Bird Cage, Strawman, Dirty Mind, Free Lemonade, Battery Pack, Key Piece 2, Unicorn Stump, The Pinking Shears, Hemoptysis, Blood Oath, Mr. Boom, TMTRAINER, Yuck Heart, Delirious, Forever Alone, The Necronomicon, <3, Poke Go, The Boomerang, Portable Slot, Punching Bag, The Poop, Angry Fly, Notched Axe, Blood Rights, Isaac's Heart, Spider Butt, Milk!, Magneto, Teleport!, Doctor's Remote, Nancy Bombs, Linger Bean, Breath of Life, The Gamekid, It Hurts, Flush!, Mom's Bra, Heartbreak, Dead Sea Scrolls, Friend Finder, Clicker, IBS, GB Bug, Mom's Heels, Slipped Rib, Leprosy, Best Friend, Lil Spewer, Hold, Tonsil, The Wiz, Meat Cleaver, The Bean, Remote Detonator, Blood Puppy, Wait What?, Tear Detonator, Brown Nugget, Compost, Little Chubby, Mega Bean, Marked, Kamikaze!, Dataminer, Bob's Rotten Head, Knife Piece 2, Spin to Win, Mine Crafter, Anarchist Cookbook, Farting Baby, The Jar, Big Chubby, Monstro's Tooth, D10, The Scooper, Broken Glass Cannon, Mom's Shovel, Shard of Glass, D12, Jar of Flies, Pause, Kidney Bean, Golden Razor, Curse of the Tower, Knife Piece 1, Sharp Key, Broken Shovel, Keeper's Kin, The Black Bean, Bumbo, Butter Bean

F Tier

Mom's Pad