The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart

A Tier

Mutant Spider, Glitched Crown, Jacob's Ladder, A Lump of Coal, More Options, Trisagion, Diplopia, Holy Light, Red Key, Technology Zero, C Section, Apple!, Eternal D6, The Parasite, Goat Head, Rock Bottom, Ceremonial Robes, Twisted Pair, Dead Eye, Head of the Keeper, Godhead, Pluto, Sacred Orb, Chaos, Holy Mantle, R Key, Athame, Birthright, Host Hat, Gnawed Leaf, The D6, Ghost Pepper, Black Candle, Mom's Knife, Cricket's Body, The Mark, The Mind, Bag of Crafting, Mystery Gift, Fire Mind, Explosivo, 8 Inch Nails, Spindown Dice, Succubus, The Small Rock, Daddy Longlegs, Technology, Spoon Bender, Binky, The Stairway, Tractor Beam, Rubber Cement, SMB Super Fan, Tech.5, Immaculate Heart, The Battery, Mucormycosis, Eucharist, Bird's Eye, Steam Sale, Tech X, Growth Hormones, D Infinity, Placenta, PJs, Abaddon, Cat-O-Nine-Tails, Blood of the Martyr, Money = Power, Death's Touch, Technology 2, The Pact, Wire Coat Hanger, Blue Map, Soy Milk, Stigmata, Monstro's Lung, Eden's Blessing

B Tier

Champion Belt, Rosary, The Soul, Dark Matter, Red Stew, Holy Grail, Eye of Belial, Sausage, Tough Love, Almond Milk, Mom's Contacts, Squeezy, Duality, Guppy's Tail, Book of Virtues, Genesis, Backstabber, Knockout Drops, Cancer, The Halo, Tooth Picks, Dead Dove, Member Card, Forget Me Now, YO LISTEN!, The Inner Eye, Capricorn, Libra, Lodestone, Spirit Sword, Guppy's Eye, Blanket, Mama Mega!, Car Battery, Little Horn (Item), Brimstone, Toxic Shock, Fruit Cake, Ocular Rift, Restock, Pentagram, Maw of the Void, Sharp Plug, Sulfur, Sacrificial Altar, Treasure Map, Fate, The Sad Onion, Book of Revelations, Lost Contact, Mom's Pearls, Mr. Dolly, The Intruder, Roid Rage, Eve's Mascara, Paschal Candle, Habit, A Dollar, Uranus, Playdough Cookie, Rotten Baby, Coupon, Dogma (Item), The Ludovico Technique, Lusty Blood, Lachryphagy, Blank Card, Gimpy, Psy Fly, Infamy, Spider Mod, Tarot Cloth, Star of Bethlehem, Mom's Key, Cricket's Head, Monstrance, Proptosis, My Reflection, Guppy's Paw, Damocles, Saturnus, Humbleing Bundle, Continuum, Voodoo Head, Pyro, Euthanasia, Incubus, Lucky Foot, Dead Cat, Synthoil, Sinus Infection, Lemegeton, Lead Pencil, Contagion, Mom's Perfume, Angelic Prism, Book of Shadows, 1up!, Scapular, Tropicamide, Terra, Sagittarius, Bot Fly, Crown of Light, Guppy's Collar, Magic Mushroom, Lord of the Pit, Ouija Board, Jumper Cables, 9 Volt, Urn of Souls, Chocolate Milk, Scorpio, Seraphim, Dark Arts, White Pony, Dog Tooth, Neptunus, 4.5 Volt, Astral Projection, Act of Contrition, Infestation 2, Guppy's Head, Eden's Soul, Spirit of the Night, Dad's Ring, Purity, Sulfuric Acid, Eye Drops, Eye of the Occult, Dark Bum, Echo Chamber, Glass Eye, Transcendence, Keeper's Sack, The Wafer, Black Lotus, Whore of Babylon, Odd Mushroom (Large), Flat Stone, Stapler, Stop Watch, BFFS!, Salvation, PHD, Blood Bag, Dead Onion, Scatter Bombs, Pop!, Parasitoid, Sacrificial Dagger, Serpent's Kiss, Trinity Shield, Leech, Marbles, Mysterious Liquid, We Need to Go Deeper!, Pyromaniac, Fanny Pack, A Bar of Soap, 3 Dollar Bill, X-Ray Vision, Mitre, The Bible, Sticky Bombs, Mom's Eye, Blue Cap, 7 Seals, Moving Box, Pisces, Gello, Torn Photo, Alabaster Box, Yum Heart, Cube of Meat, Revelation, The Mulligan, Plum Flute, Freezer Baby, Crystal Ball, Mr. ME!, Mini Mush, Worm Friend, Pupula Duplex, The Body, Cambion Conception, Schoolbag, Compound Fracture, Sack Head, Charged Baby, Gemini (Item), Binge Eater, Magic Skin

C Tier

Censer, Lil Dumpy, Virgo, Camo Undies, Odd Mushroom (Thin), A Pony, Screw, Divorce Papers, Rotten Tomato, Lil Brimstone, Sissy Longlegs, Skeleton Key, Tiny Planet, Shoop Da Whoop!, Rune Bag, Speed Ball, Bozo, Options?, 120 Volt, D20, Mega Mush, Bloody Lust, Big Fan, Lil Abaddon, The Polaroid, Dry Baby, Charm of the Vampire, Black Hole, Mom's Purse, False PHD, Multidimensional Baby, Adrenaline, Evil Charm, Prayer Card, Kidney Stone, 20/20, Chemical Peel, Aquarius, Divine Intervention, Skatole, Analog Stick, Glitter Bombs, Iron Bar, Azazel's Rage, Smelter, Cupid's Arrow, Contract From Below, Maggy's Bow, Book of Secrets, Magic Scab, The Common Cold, Mars, Brittle Bones, Judas' Shadow, Little Steven, Old Bandage, The Nail, Metal Plate, Boom!, Holy Water, Soul Locket, Flip, Epiphora, Hungry Soul, Raw Liver, Marrow, BBF, Ghost Bombs, Magic 8 Ball, Lunch, Varicose Veins, Consolation Prize, Jesus Juice, There's Options, Suplex!, Sack of Pennies, Box of Friends, Polyphemus, Midas' Touch, The Book of Belial, Card Reading, Spear of Destiny, Cone Head, Telepathy for Dummies, Broken Modem, Empty Vessel, Greed's Gullet, Starter Deck, Vanishing Twin, Orphan Socks, Quints, The Compass, Brother Bobby, Loki's Horns, D1, Deep Pockets, MEAT!, Dad's Key, Tooth and Nail, Breakfast, Haemolacria, Crooked Penny, Taurus, Dream Catcher, Tammy's Head, Dad's Lost Coin, Luna, The Swarm, Papa Fly, Redemption, Mercurius, The Book of Sin, Montezuma's Revenge, Thunder Thighs, Rocket in a Jar, Mom's Ring, Head of Krampus, Jaw Bone, Guppy's Hair Ball, The Candle, Anemic, Isaac's Tomb, Robo-Baby 2.0, Dark Prince's Crown, Hallowed Ground, Bogo Bombs, Buddy in a Box, Immaculate Conception, Box of Spiders, Fortune Cookie, Giant Cell, Acid Baby, Robo-Baby, Juicy Sack, Hive Mind, Recall, Polydactyly, Stem Cells, Butt Bombs, The Ladder, Belly Button, Lil Loki, Spiderbaby, The Negative, Blood Clot, Box, Safety Pin, Purgatory, Caffeine Pill, Stye, Anima Sola, Cain's Other Eye, Experimental Treatment, Little C.H.A.D., Halo of Flies, Evil Eye, Lil Monstro, Number One, Smart Fly, The Relic, Bob's Curse, Ipecac, Lost Soul, Spider Bite, Inner Child, Latch Key, Spelunker Hat, Bomber Boy, Bobby-Bomb, Dead Bird, Steven (Item), Glyph of Balance, Boiled Baby, Mystery Sack, Cracked Orb, Book of the Dead, No. 2, Distant Admiration, Spirit Shackles, Everything Jar, Eye of Greed, Harlequin Baby, Sad Bombs, Black Powder, Ankh, Sworn Protector, Vade Retro, Midnight Snack, D100, Large Zit, King Baby, Cube Baby, A Quarter, Rainbow Baby, Key Piece 1, Lil Portal, Stitches, The Peeper, Zodiac, ???'s Only Friend, Monster Manual, Mongo Baby, Wooden Nickel, Sol, D4, Decap Attack, Satanic Bible, Lil Gurdy, Isaac's Tears, Venus, Death's List, Void, Bursting Sack, Larynx, Sister Maggy, Berserk!, Clear Rune, Finger!, Aries, Lazarus' Rags, E. Coli, Jar of Wisps, Pandora's Box, Glass Cannon, Super Bandage, Bum Friend, Potato Peeler, Infestation, The Belt, The Virus, Lemon Mishap, Match Book, Brimstone Bombs, Mr. Mega, Telekinesis, Fate's Reward, Crack the Sky, Betrayal, Epic Fetus, Sumptorium

D Tier

Demon Baby, Vasculitis, A Pound of Flesh, Bloodshot Eye, Razor Blade, Mom's Bracelet, Dr. Fetus, My Shadow, Mom's Eyeshadow, Obsessed Fan, My Little Unicorn, Vengeful Spirit, Belly Jelly, IV Bag, Mystery Egg, Glaucoma, Guillotine, Mega Blast, Deck of Cards, Hypercoagulation, Mom's Underwear, Ghost Baby, Bloody Gust, Fast Bombs, Fruity Plum, Guardian Angel, Placebo, How to Jump, Abyss, Pageant Boy, Circle of Protection, Mom's Box, Blood Bombs, Lil Haunt, Friend Zone, Night Light, Ventricle Razor, Friendly Ball, Glowing Hourglass, Teleport 2.0, Pointy Rib, Cursed Eye, Hushy, Jupiter, Delirious, Dead Tooth, Free Lemonade, Mom's Lipstick, Celtic Cross, Lil Chest, Piggy Bank, 2Spooky, Isaac's Heart, Abel, Supper, Dad's Note, Mom's Coin Purse, The Hourglass, The Poop, Pay to Play, Bone Spurs, Lil Delirium, Rotten Meat, Golden Razor, Keeper's Box, Wooden Spoon, Sack of Sacks, Hot Bombs, The Boomerang, Unicorn Stump, Magic Fingers, Ball of Bandages, Mom's Razor, Samson's Chains, Battery Pack, Key Bum, Crack Jacks, Sharp Straw, The Pinking Shears, Portable Slot, Dull Razor, Dinner, Tinytoma, Mr. Boom, Metronome, Booster Pack (Item), Mom's Wig, Little Baggy, Bob's Brain, Strawman, Best Bud, Dessert, Lil Spewer, Missing No., Spider Butt, Poke Go, Eye Sore, TMTRAINER, Bucket of Lard, Eraser, Yuck Heart, The Gamekid, Blood Rights, Undefined, Depression, Lost Fly, Bird Cage, Empty Heart, Candy Heart, Wavy Cap, Esau Jr., Remote Detonator, Mom's Bottle of Pills, Broken Watch, Dead Sea Scrolls, Milk!, Key Piece 2, Scissors, Hemoptysis, D7, Clicker, Linger Bean, Punching Bag, Blood Oath, Heartbreak, IBS, Little Gish, Plan C, Headless Baby, Missing Page 2, Mom's Bra, Shade, Sanguine Bond, Mom's Heels, The Necronomicon, It Hurts, Converter, God's Flesh, Slipped Rib, GB Bug, D8, Mega Bean, Hold, Broken Glass Cannon, Ball of Tar, Dataminer, Red Candle, Dirty Mind, Notched Axe, Marked, Monstro's Tooth, Breath of Life, Nancy Bombs, Doctor's Remote, Angry Fly, Best Friend, Anti-Gravity, Bomb Bag, Magneto, Teleport!, Tonsil, Forever Alone, Meat Cleaver, Flush!, Leo, <3, Mine Crafter, Knife Piece 2, Wait What?, Strange Attractor, Tear Detonator, The Bean, Compost, Spin to Win, Brown Nugget, Kamikaze!, Bob's Rotten Head, Jar of Flies, The Scooper, Friend Finder, Sprinkler, A Snack, Blood Puppy, Little Chubby, The Wiz, Big Chubby, Akeldama, Leprosy, Mom's Pad

F Tier

Anarchist Cookbook, Farting Baby, Curse of the Tower, Shard of Glass, D12, Pause, Knife Piece 1, D10, Broken Shovel, Kidney Bean, The Jar, Mom's Shovel, Sharp Key, Bumbo, Butter Bean, Keeper's Kin, The Black Bean