The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Mutant Spider

A Tier

Glitched Crown, Jacob's Ladder, A Lump of Coal, More Options, Trisagion, Holy Light, Diplopia, Red Key, Apple!, Technology Zero, Eternal D6, The Parasite, Rock Bottom, C Section, Goat Head, Ceremonial Robes, Twisted Pair, Dead Eye, Chaos, Godhead, Birthright, Sacred Orb, Athame, Head of the Keeper, Host Hat, Gnawed Leaf, Pluto, Cricket's Body, Ghost Pepper, Holy Mantle, R Key, Bag of Crafting, The D6, Fire Mind, Explosivo, Succubus, Mom's Knife, 8 Inch Nails, Spindown Dice, The Small Rock, Spoon Bender, The Stairway, Binky, Mystery Gift, Immaculate Heart, Rubber Cement, Black Candle, The Mark, Mucormycosis, Technology, Tech.5, Bird's Eye, The Mind, Steam Sale, Tractor Beam, Growth Hormones, SMB Super Fan, Placenta, Cat-O-Nine-Tails, Abaddon, The Battery, D Infinity, Blood of the Martyr, Technology 2, Wire Coat Hanger, Daddy Longlegs, Soy Milk, Eden's Blessing, Death's Touch, Blue Map, Cancer, Tech X, Eucharist, Dark Matter, Tough Love, Eye of Belial, Almond Milk

B Tier

The Pact, Stigmata, Guppy's Tail, Knockout Drops, The Halo, Tooth Picks, Rosary, PJs, Backstabber, Champion Belt, Money = Power, YO LISTEN!, Sausage, Holy Grail, Libra, Squeezy, Capricorn, Little Horn (Item), Lodestone, Fruit Cake, Forget Me Now, Monstro's Lung, Member Card, Dead Dove, Ocular Rift, The Soul, Lost Contact, Maw of the Void, Pentagram, Book of Revelations, Red Stew, Spirit Sword, Book of Virtues, Guppy's Eye, Brimstone, Duality, Roid Rage, Car Battery, Mom's Contacts, Genesis, Eve's Mascara, Paschal Candle, Coupon, Sulfur, Proptosis, Lachryphagy, Lusty Blood, Mom's Pearls, The Inner Eye, Infamy, Blanket, Voodoo Head, Toxic Shock, Playdough Cookie, Book of Shadows, Continuum, Dogma (Item), Sharp Plug, Euthanasia, Restock, Psy Fly, Mama Mega!, Treasure Map, Sacrificial Altar, Gimpy, Spider Mod, Lead Pencil, Sinus Infection, The Sad Onion, Star of Bethlehem, Tarot Cloth, Cricket's Head, Tropicamide, My Reflection, Mr. Dolly, 1up!, Fate, Habit, Angelic Prism, Humbleing Bundle, The Intruder, Sagittarius, Saturnus, Scapular, Pyro, A Dollar, Bot Fly, Jumper Cables, Dead Cat, Uranus, The Ludovico Technique, Incubus, Synthoil, Chocolate Milk, Rotten Baby, Lord of the Pit, Scorpio, Lemegeton, Guppy's Paw, Contagion, Blank Card, Mom's Key, Dog Tooth, Damocles, Monstrance, Terra, Magic Mushroom, Dark Arts, Sulfuric Acid, Crown of Light, Flat Stone, Lucky Foot, Purity, Eye Drops, Mom's Perfume, Leech, Dark Bum, Black Lotus, Stapler, 4.5 Volt, Odd Mushroom (Large), Salvation, Guppy's Collar, Serpent's Kiss, Eden's Soul, Ouija Board, Astral Projection, 9 Volt, Trinity Shield, Mysterious Liquid, X-Ray Vision, Seraphim, A Bar of Soap, Urn of Souls, Dad's Ring, We Need to Go Deeper!, Transcendence, Torn Photo, Blue Cap, Echo Chamber, BFFS!, Whore of Babylon, Blood Bag, Worm Friend, Pisces, Neptunus, Crystal Ball, Act of Contrition, Fanny Pack, 7 Seals, White Pony, Stop Watch, Marbles, Spirit of the Night, Pupula Duplex, Infestation 2, 3 Dollar Bill, Guppy's Head, The Wafer, Eye of the Occult, Mitre, Sacrificial Dagger, Lil Dumpy, Pyromaniac, Divorce Papers, Keeper's Sack, Charged Baby, Mr. ME!, Glass Eye, PHD, Pop!, Dead Onion, Gello, Alabaster Box, Scatter Bombs, Compound Fracture, Parasitoid, Censer, The Body, Revelation, Sticky Bombs, Mom's Eye, Camo Undies, Analog Stick, Charm of the Vampire, Sack Head, Gemini (Item), Rotten Tomato, Yum Heart, Cube of Meat, The Mulligan, Sissy Longlegs, Mini Mush, Cupid's Arrow, Freezer Baby, Skeleton Key, Rune Bag

C Tier

Cambion Conception, Book of Secrets, Schoolbag, Mom's Purse, Divine Intervention, Moving Box, Bloody Lust, The Bible, False PHD, Odd Mushroom (Thin), Metal Plate, Tiny Planet, Prayer Card, Screw, Chemical Peel, Virgo, Magic Skin, Midas' Touch, Big Fan, Lil Abaddon, Glitter Bombs, Plum Flute, Binge Eater, Magic 8 Ball, Shoop Da Whoop!, Jesus Juice, 120 Volt, Options?, Evil Charm, There's Options, Bozo, Adrenaline, Speed Ball, 20/20, Kidney Stone, The Polaroid, Multidimensional Baby, D20, Black Hole, Mega Mush, Polyphemus, Azazel's Rage, Holy Water, Contract From Below, The Book of Belial, Dry Baby, Loki's Horns, Ghost Bombs, Taurus, A Pony, Aquarius, Consolation Prize, Lil Brimstone, Skatole, Iron Bar, Maggy's Bow, The Relic, Flip, Dad's Lost Coin, Judas' Shadow, Magic Scab, Mars, The Common Cold, The Compass, The Nail, Spider Bite, Anemic, Little Steven, Old Bandage, Haemolacria, Boom!, Caffeine Pill, Smelter, Hungry Soul, Soul Locket, Raw Liver, Marrow, Lunch, Cone Head, Broken Modem, Greed's Gullet, Sack of Pennies, Box of Friends, Vanishing Twin, Orphan Socks, Card Reading, Book of the Dead, Luna, Starter Deck, Safety Pin, Telepathy for Dummies, Crooked Penny, Brother Bobby, Varicose Veins, Brittle Bones, Deep Pockets, Quints, MEAT!, BBF, Suplex!, Empty Vessel, Breakfast, Tooth and Nail, Dad's Key, Dark Prince's Crown, Number One, Papa Fly, Epiphora, Spear of Destiny, Bogo Bombs, Smart Fly, D1, Redemption, The Book of Sin, Montezuma's Revenge, Guppy's Hair Ball, Mom's Ring, Isaac's Tomb, Rocket in a Jar, The Ladder, Belly Button, Lil Portal, The Candle, Blood Clot, Spelunker Hat, Acid Baby, Hallowed Ground, Evil Eye, Eye of Greed, Halo of Flies, Head of Krampus, Jaw Bone, Thunder Thighs, Buddy in a Box, The Swarm, Box of Spiders, Giant Cell, Dream Catcher, Recall, Mercurius, Robo-Baby, Robo-Baby 2.0, Tammy's Head, Juicy Sack, Immaculate Conception, The Negative, Lil Loki, Spiderbaby, Purgatory, Stye, Cain's Other Eye, Anima Sola, Rainbow Baby, Experimental Treatment, Black Powder, Little C.H.A.D., Lost Soul, Lil Monstro, Polydactyly, Stem Cells, Inner Child, Bomber Boy, Latch Key, Fortune Cookie, Monster Manual, Hive Mind, Mystery Sack, Cracked Orb, Sol, Dead Bird, Steven (Item), Venus, Boiled Baby, Butt Bombs, No. 2, Spirit Shackles, Distant Admiration, Everything Jar, Harlequin Baby, Sad Bombs, Ipecac, Death's List, Bobby-Bomb, Ankh, D100, Box, Bob's Curse, Large Zit, Zodiac, Key Piece 1, Stitches, The Peeper, ???'s Only Friend, Mongo Baby, Wooden Nickel, Decap Attack, D4, Glyph of Balance, King Baby, Vade Retro, A Quarter, Glaucoma, Isaac's Tears, Sworn Protector, Satanic Bible, Midnight Snack, Larynx, Sister Maggy, Berserk!, Clear Rune, Finger!, Aries, Lazarus' Rags, Cube Baby, Pandora's Box, Bloody Gust, Jar of Wisps, Glass Cannon, Lil Gurdy, Bum Friend, Void, Mom's Eyeshadow, Obsessed Fan, Bursting Sack, The Belt, The Virus, Brimstone Bombs, Telekinesis, Mr. Mega, Placebo, Fast Bombs, Glowing Hourglass, Fate's Reward, Pageant Boy, Betrayal, Super Bandage, Bloodshot Eye, Epic Fetus, Sumptorium

D Tier

A Pound of Flesh, E. Coli, Infestation, Lemon Mishap, Vengeful Spirit, Potato Peeler, My Shadow, Dr. Fetus, Key Bum, Little Baggy, Celtic Cross, Abyss, Deck of Cards, Mom's Wig, Demon Baby, Mom's Underwear, Match Book, Guardian Angel, Ghost Baby, Razor Blade, Crack the Sky, Hypercoagulation, Circle of Protection, Blood Bombs, Mom's Box, Friendly Ball, Night Light, Lil Haunt, Friend Zone, Mystery Egg, Mom's Bracelet, Mega Blast, Vasculitis, Bob's Brain, My Little Unicorn, Belly Jelly, Pointy Rib, Delirious, Dead Tooth, Guillotine, Piggy Bank, Mom's Lipstick, IV Bag, Lil Chest, 2Spooky, Abel, Dad's Note, Supper, Fruity Plum, The Hourglass, Isaac's Heart, How to Jump, Lil Delirium, Ventricle Razor, Hot Bombs, Bone Spurs, Cursed Eye, Hushy, Mom's Razor, Mom's Coin Purse, Jupiter, Ball of Bandages, Sharp Straw, Keeper's Box, Crack Jacks, Samson's Chains, Sack of Sacks, Mr. Boom, Rotten Meat, Teleport 2.0, Mom's Bottle of Pills, Free Lemonade, Wooden Spoon, Tinytoma, Best Bud, Unicorn Stump, Dessert, Pay to Play, Ball of Tar, Metronome, Magic Fingers, Booster Pack (Item), Eye Sore, The Poop, Strawman, Portable Slot, The Pinking Shears, Bucket of Lard, Eraser, Missing No., Missing Page 2, Golden Razor, Battery Pack, TMTRAINER, Lil Spewer, The Boomerang, Dinner, Dull Razor, Shade, Empty Heart, Undefined, Broken Watch, The Necronomicon, Lost Fly, Dead Sea Scrolls, Scissors, Spider Butt, Poke Go, Wavy Cap, Esau Jr., Leo, Punching Bag, Candy Heart, Yuck Heart, The Gamekid, Blood Oath, Little Gish, Blood Rights, Hemoptysis, Bird Cage, Milk!, Mom's Bra, D7, Converter, Strange Attractor, Sanguine Bond, God's Flesh, Depression, Remote Detonator, Heartbreak, IBS, GB Bug, Plan C, Key Piece 2, Anti-Gravity, Mom's Heels, Red Candle, Linger Bean, Broken Glass Cannon, Notched Axe, Clicker, Headless Baby, Dirty Mind, It Hurts, D8, Slipped Rib, Breath of Life, Dataminer, Angry Fly, Teleport!, Forever Alone, Meat Cleaver, Tonsil, Hold, Mega Bean, Nancy Bombs, <3, Doctor's Remote, Sprinkler, Best Friend, Magneto, Bomb Bag, Marked, Monstro's Tooth, Brown Nugget, Akeldama, Tear Detonator, Compost, Flush!, Mine Crafter, Wait What?, The Bean, A Snack, Spin to Win, Little Chubby, Kamikaze!, Knife Piece 2, Jar of Flies, The Wiz, D10, Friend Finder, Leprosy, Bob's Rotten Head, Anarchist Cookbook, The Scooper, Blood Puppy, Big Chubby, The Jar

F Tier

Mom's Pad, Farting Baby, Curse of the Tower, Shard of Glass, D12, Pause, Knife Piece 1, Broken Shovel, Kidney Bean, Mom's Shovel, Sharp Key, Bumbo, Butter Bean, Keeper's Kin, The Black Bean