The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Rock Bottom, Glitched Crown, Birthright

A Tier

Jacob's Ladder, Mutant Spider, More Options, A Lump of Coal, Diplopia, Holy Light, Red Key, Technology Zero, C Section, Trisagion, Black Candle, Eternal D6, Mystery Gift, The Parasite, Goat Head, Twisted Pair, Apple!, Dead Eye, Godhead, The Stairway, Head of the Keeper, Ceremonial Robes, Sacred Orb, R Key, Binky, Chaos, Holy Mantle, The D6, Athame, Host Hat, Mom's Knife, Pluto, Gnawed Leaf, Book of Virtues, Spindown Dice, Ghost Pepper, Cricket's Body, The Mind, Blood of the Martyr, The Mark, Explosivo, Succubus, Technology 2, Spirit Sword, Daddy Longlegs, Steam Sale, Technology, Soy Milk, Eden's Blessing, Fire Mind, Dead Dove, Spoon Bender, Humbleing Bundle, 8 Inch Nails, The Small Rock, Tractor Beam, The Halo, Genesis, Tech X, YO LISTEN!, D Infinity, Rubber Cement, SMB Super Fan, Immaculate Heart, Member Card, Bag of Crafting, Tech.5, Mom's Contacts, Guppy's Eye, Eucharist, Tooth Picks, Knockout Drops, Bird's Eye, Fate, Blue Map, Forget Me Now, Mucormycosis, Growth Hormones, Abaddon

B Tier

Eye of Belial, PJs, Lodestone, Car Battery, Placenta, Money = Power, Cat-O-Nine-Tails, Treasure Map, Ocular Rift, The Battery, Restock, Lost Contact, Fruit Cake, The Pact, Sharp Plug, Voodoo Head, Paschal Candle, Tough Love, Wire Coat Hanger, Playdough Cookie, Rosary, Death's Touch, Spider Mod, Mr. Dolly, The Sad Onion, Moving Box, The Soul, Red Stew, Lachryphagy, Eve's Mascara, Champion Belt, Stigmata, Backstabber, Holy Grail, Almond Milk, Mr. ME!, Dark Matter, A Dollar, Habit, Guppy's Tail, Sausage, Monstro's Lung, Blank Card, Rotten Baby, The Ludovico Technique, Cancer, Brimstone, Duality, Sinus Infection, Mom's Key, Tarot Cloth, Scorpio, Transcendence, Magic Skin, Dead Cat, Squeezy, The Inner Eye, Damocles, Pyro, Lucky Foot, Pentagram, Little Horn (Item), Euthanasia, Maw of the Void, Capricorn, Blanket, Toxic Shock, Book of Shadows, Terra, Whore of Babylon, Lil Dumpy, Lemegeton, Mom's Perfume, White Pony, Blood Bag, Psy Fly, Angelic Prism, Incubus, Tropicamide, Scapular, Sulfur, Cricket's Head, We Need to Go Deeper!, Schoolbag, Libra, Mama Mega!, Roid Rage, Neptunus, Dark Arts, 9 Volt, Sulfuric Acid, Gimpy, Chocolate Milk, Book of Revelations, Infestation 2, The Intruder, Infamy, Sacrificial Altar, Seraphim, Eden's Soul, Flat Stone, Guppy's Paw, Crown of Light, Coupon, Lusty Blood, Astral Projection, Echo Chamber, Saturnus, My Reflection, Act of Contrition, Mom's Pearls, Magic Mushroom, Options?, Spirit of the Night, Star of Bethlehem, Continuum, Serpent's Kiss, Purity, Marbles, Eye of the Occult, Glitter Bombs, Mysterious Liquid, X-Ray Vision, Sticky Bombs, Uranus, BFFS!, Keeper's Sack, Dogma (Item), Contagion, Blue Cap, Odd Mushroom (Large), Torn Photo, Magic Scab, Leech, PHD, Pop!, Bot Fly, Monstrance, Fanny Pack, Sacrificial Dagger, Parasitoid, Worm Friend, Book of Secrets, Kidney Stone, Guppy's Collar, Crystal Ball, The Wafer, Stop Watch, Lead Pencil, Ouija Board, 3 Dollar Bill, Pyromaniac, Lord of the Pit, Mom's Eye, Little Steven, The Bible, Yum Heart, Revelation, Gello, Urn of Souls, Alabaster Box, Dry Baby, Pisces, Proptosis, Synthoil, 1up!, Virgo, A Pony, Freezer Baby, Black Lotus, Glass Eye, 4.5 Volt, Jumper Cables, There's Options, Sissy Longlegs, Consolation Prize, Sagittarius, Dark Bum, Lil Brimstone, Eye Drops, Judas' Shadow, Rune Bag, Dad's Ring, Skeleton Key, Binge Eater, Bozo, MEAT!, Dog Tooth, Sack Head, Compound Fracture, Gemini (Item)

C Tier

Contract From Below, Crooked Penny, Recall, The Polaroid, Black Hole, Mega Mush, Lil Abaddon, Evil Charm, Adrenaline, The Book of Belial, Trinity Shield, Tiny Planet, Shoop Da Whoop!, Salvation, Guppy's Head, Dead Onion, D20, Smelter, Aquarius, Scatter Bombs, Multidimensional Baby, 7 Seals, Luna, Maggy's Bow, Mini Mush, Prayer Card, Mitre, The Common Cold, Divine Intervention, 20/20, A Bar of Soap, Holy Water, Boom!, Iron Bar, Juicy Sack, Ghost Bombs, Magic 8 Ball, Cambion Conception, Stapler, Censer, Mars, Odd Mushroom (Thin), Plum Flute, Brittle Bones, Flip, Bloody Lust, Cube of Meat, Old Bandage, Broken Modem, Charged Baby, Metal Plate, Quints, Latch Key, Empty Vessel, Rocket in a Jar, The Body, Everything Jar, Orphan Socks, Loki's Horns, Soul Locket, Dad's Key, Screw, The Mulligan, Polyphemus, Sack of Pennies, Suplex!, Breakfast, Skatole, The Negative, Box of Friends, Bobby-Bomb, Spear of Destiny, Dream Catcher, False PHD, Cain's Other Eye, Card Reading, Big Fan, The Swarm, Starter Deck, Glyph of Balance, Vanishing Twin, Telepathy for Dummies, Rotten Tomato, Mercurius, Deep Pockets, Bomber Boy, Spirit Shackles, Montezuma's Revenge, Thunder Thighs, Stitches, Mom's Ring, Haemolacria, Pupula Duplex, Azazel's Rage, Guppy's Hair Ball, Taurus, Divorce Papers, Midas' Touch, The Candle, Anemic, Charm of the Vampire, 120 Volt, Mom's Purse, Zodiac, Papa Fly, Cube Baby, Robo-Baby 2.0, The Nail, Camo Undies, Hallowed Ground, Caffeine Pill, Epiphora, Chemical Peel, Buddy in a Box, The Peeper, Box of Spiders, Fortune Cookie, Jaw Bone, Giant Cell, Sumptorium, Robo-Baby, Pandora's Box, Isaac's Tomb, Sol, Hive Mind, Polydactyly, Speed Ball, Bogo Bombs, BBF, Analog Stick, Jar of Wisps, Purgatory, Immaculate Conception, Hungry Soul, Acid Baby, Brother Bobby, Halo of Flies, Cupid's Arrow, Jesus Juice, Smart Fly, Number One, The Relic, Greed's Gullet, Lunch, Varicose Veins, Raw Liver, Stem Cells, The Ladder, Inner Child, Belly Button, Blood Clot, Fate's Reward, Ipecac, Mr. Mega, Mystery Sack, Dead Bird, The Compass, Boiled Baby, Little C.H.A.D., Box, D1, Safety Pin, Eye of Greed, Teleport 2.0, The Book of Sin, Distant Admiration, Bob's Curse, Harlequin Baby, Lost Soul, Experimental Treatment, Dad's Lost Coin, Sad Bombs, Lil Monstro, Spelunker Hat, Sworn Protector, Brimstone Bombs, Marrow, My Little Unicorn, Satanic Bible, Spider Bite, Midnight Snack, Spiderbaby, My Shadow, Monster Manual, ???'s Only Friend, No. 2, Key Piece 1, Tooth and Nail, Dark Prince's Crown, Glowing Hourglass, A Quarter, Blood Bombs, How to Jump, Wooden Nickel, Redemption, Ventricle Razor, Guardian Angel, Venus, Void, Fast Bombs, Isaac's Tears, Ankh, Head of Krampus, Cone Head, Bursting Sack, King Baby, Book of the Dead, Hushy, Sister Maggy, Circle of Protection, Finger!, Clear Rune, Rainbow Baby, Super Bandage, Jupiter, D4, Dead Tooth, Decap Attack, Evil Eye, The Poop, Golden Razor

D Tier

Lil Portal, Mom's Lipstick, Potato Peeler, Aries, Tammy's Head, Lil Gurdy, Dr. Fetus, Death's List, The Boomerang, Keeper's Box, Magic Fingers, Pay to Play, Telekinesis, Butt Bombs, Epic Fetus, Lemon Mishap, Lil Loki, Lil Delirium, Larynx, Crack the Sky, The Belt, Mom's Box, Infestation, Cracked Orb, Sharp Straw, Dull Razor, Bloodshot Eye, Bum Friend, Black Powder, Wooden Spoon, Rotten Meat, Unicorn Stump, Ball of Bandages, Portable Slot, Dinner, Mom's Bracelet, Crack Jacks, Missing No., Vengeful Spirit, Demon Baby, Lil Spewer, A Pound of Flesh, Razor Blade, Steven (Item), The Virus, Eye Sore, Mega Blast, Match Book, Ghost Baby, Lazarus' Rags, Abyss, Best Bud, The Gamekid, Hypercoagulation, Depression, Large Zit, Vade Retro, Fruity Plum, Eraser, Undefined, Mongo Baby, Pageant Boy, Bucket of Lard, Empty Heart, Deck of Cards, Friend Zone, Lost Fly, Lil Haunt, Anima Sola, Candy Heart, Night Light, Guillotine, Hemoptysis, Belly Jelly, Wavy Cap, Delirious, Mystery Egg, Mom's Bottle of Pills, Stye, D7, Lil Chest, Pointy Rib, 2Spooky, Key Piece 2, Booster Pack (Item), Placebo, IV Bag, Mom's Wig, Milk!, Glaucoma, Abel, Supper, Dad's Note, Poke Go, Punching Bag, Free Lemonade, Mom's Coin Purse, Cursed Eye, Little Gish, It Hurts, Mom's Eyeshadow, D100, Isaac's Heart, Mom's Bra, Berserk!, Celtic Cross, Plan C, Piggy Bank, GB Bug, Betrayal, Bone Spurs, Sanguine Bond, Mega Bean, Slipped Rib, Glass Cannon, Samson's Chains, The Pinking Shears, Sack of Sacks, Hold, Friendly Ball, Ball of Tar, Dessert, Notched Axe, Little Baggy, Red Candle, Bob's Brain, Battery Pack, Dataminer, Key Bum, Monstro's Tooth, Spider Butt, Nancy Bombs, Doctor's Remote, Strawman, Hot Bombs, E. Coli, Breath of Life, Obsessed Fan, Best Friend, Mr. Boom, Bird Cage, Angry Fly, Bloody Gust, Blood Rights, Mom's Razor, Teleport!, Magneto, Meat Cleaver, Anti-Gravity, Bomb Bag, Tonsil, Vasculitis, Leo, Blood Oath, Flush!, Mine Crafter, Dead Sea Scrolls, Tear Detonator, Heartbreak, Missing Page 2, Spin to Win, Metronome, Wait What?, Yuck Heart, Strange Attractor, Headless Baby, The Necronomicon, Mom's Underwear, Remote Detonator, Linger Bean, Brown Nugget, Broken Watch, Friend Finder, Esau Jr., Bob's Rotten Head, The Scooper, Converter, Shade, Mom's Heels, Scissors, IBS, D8, Little Chubby, The Wiz, Clicker, Broken Glass Cannon, Dirty Mind, Leprosy, The Hourglass, God's Flesh, Akeldama, Anarchist Cookbook, Farting Baby, Mom's Pad, Kamikaze!, Curse of the Tower, Marked, Shard of Glass, D12, Tinytoma, TMTRAINER

F Tier

Pause, Knife Piece 2, Knife Piece 1, D10, Kidney Bean, The Jar, Broken Shovel, <3, Compost, Forever Alone, Sharp Key, The Bean, Mom's Shovel, Sprinkler, A Snack, Bumbo, Big Chubby, Butter Bean, Jar of Flies, Keeper's Kin, Blood Puppy, The Black Bean