The Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Glitched Crown

A Tier

C Section, Twisted Pair, Sacred Orb, Godhead, R Key, The D6, Holy Mantle, Mom's Knife, Spindown Dice, D Infinity, Tech X, Brimstone, Cricket's Head, Psy Fly, Incubus, Mutant Spider, Magic Mushroom, Goat Head, Trisagion, A Lump of Coal, Crown of Light, Jacob's Ladder, Red Key, The Parasite, More Options, Rock Bottom, Ceremonial Robes, The Wafer, Stop Watch, Eternal D6, Birthright, Diplopia, Pyromaniac, Holy Light, Apple!, Revelation, Succubus, Athame, The Stairway, 20/20, Technology Zero, Spoon Bender, Chaos, Mega Mush, Pluto, Dead Eye, Polyphemus, Ghost Pepper, Binge Eater, Cricket's Body, Flip, 8 Inch Nails, The Mark, Immaculate Heart, Technology, The Mind, Gnawed Leaf, Host Hat, Eye of Belial, The Pact, Fire Mind, Death's Touch, Tractor Beam, Little Horn (Item), Mystery Gift, Steam Sale, Haemolacria, Bird's Eye, Blood of the Martyr, Abaddon, Backstabber, Sausage, Lusty Blood, Rubber Cement, Tech.5, Binky, Head of the Keeper, Spirit Sword, Dark Matter, The Halo, SMB Super Fan, Tough Love, Black Candle, Bag of Crafting, Genesis, The Small Rock, Holy Grail, Ocular Rift, Book of Revelations, Money = Power, Technology 2, Growth Hormones, Fruit Cake

B Tier

Capricorn, Eden's Blessing, Rotten Baby, Pentagram, Dead Cat, Daddy Longlegs, Dead Dove, Guppy's Eye, Cat-O-Nine-Tails, Explosivo, Stigmata, Dogma (Item), Maw of the Void, Lemegeton, Eucharist, YO LISTEN!, Star of Bethlehem, Lachryphagy, Guppy's Tail, Squeezy, Cancer, PJs, Libra, Paschal Candle, The Battery, Soy Milk, Terra, Blue Map, Dark Arts, Red Stew, Book of Shadows, Fate, Mucormycosis, Wire Coat Hanger, Duality, Book of Virtues, Rosary, Monstro's Lung, Lost Contact, The Inner Eye, Placenta, Lodestone, Proptosis, Ipecac, Blanket, Car Battery, Knockout Drops, Tooth Picks, Saturnus, Forget Me Now, Eve's Mascara, Voodoo Head, Damocles, Lord of the Pit, Sulfur, Worm Friend, Member Card, Toxic Shock, Purity, Sharp Plug, Mr. Dolly, Eye of the Occult, Mama Mega!, Humbleing Bundle, Blank Card, Dog Tooth, Habit, Uranus, Seraphim, Sulfuric Acid, Whore of Babylon, Mom's Contacts, Satanic Bible, Monstrance, Champion Belt, A Dollar, The Soul, Dark Bum, Stapler, 9 Volt, Almond Milk, My Reflection, Sagittarius, Coupon, Act of Contrition, Roid Rage, Lead Pencil, Gello, Bot Fly, Odd Mushroom (Large), Spirit of the Night, 4.5 Volt, The Sad Onion, Pyro, Scapular, Infestation 2, Lil Dumpy, Sacrificial Dagger, Euthanasia, Angelic Prism, Guppy's Paw, Synthoil, Restock, Mom's Key, X-Ray Vision, Gimpy, Continuum, Salvation, Flat Stone, Jumper Cables, Sinus Infection, Blue Cap, We Need to Go Deeper!, Keeper's Sack, Camo Undies, Tarot Cloth, Sacrificial Altar, Serpent's Kiss, 1up!, The Intruder, Void, Compound Fracture, Guppy's Collar, Charged Baby, Infamy, PHD, The Body, Transcendence, 7 Seals, Treasure Map, The Ludovico Technique, Lucky Foot, Scorpio, Options?, Playdough Cookie, Crystal Ball, Spider Mod, Contagion, Charm of the Vampire, Lil Abaddon, Sack Head, Black Lotus, Eden's Soul, Mom's Pearls, Lil Brimstone, Rune Bag, Ouija Board, Chocolate Milk, Neptunus, Trinity Shield, Parasitoid, There's Options, BFFS!, Dead Onion, Epic Fetus, Judas' Shadow, Pisces, A Bar of Soap, Echo Chamber, Censer, Mitre, Blood Bag, Urn of Souls, Tropicamide, Dr. Fetus, Leech, Marbles, White Pony, Abyss, 3 Dollar Bill, Eye Drops, Guppy's Head, Mr. ME!, Mysterious Liquid, Cambion Conception, Torn Photo, Skeleton Key, Mini Mush, The Polaroid, Bloody Lust, The Mulligan, Dad's Ring, Schoolbag, Multidimensional Baby, Freezer Baby, Odd Mushroom (Thin), Sissy Longlegs, Magic 8 Ball, Orphan Socks, Consolation Prize, Cupid's Arrow, Speed Ball, Glass Eye, The Relic, Divine Intervention, Virgo, Divorce Papers, Alabaster Box, Crooked Penny, Rotten Tomato, Jesus Juice, Mars, Fanny Pack

C Tier

Dry Baby, False PHD, Magic Scab, Mega Blast, Mom's Perfume, Yum Heart, Kidney Stone, Book of Secrets, Starter Deck, Pop!, Holy Water, A Pony, The Nail, Cone Head, Astral Projection, Analog Stick, Adrenaline, The Compass, The Book of Belial, Luna, Pupula Duplex, The Bible, Broken Modem, Cube of Meat, Scatter Bombs, Ghost Bombs, 120 Volt, Chemical Peel, Little Steven, Tooth and Nail, Screw, MEAT!, Book of the Dead, Raw Liver, Maggy's Bow, Aquarius, Mom's Purse, Hungry Soul, Old Bandage, Gemini (Item), Everything Jar, D20, Tiny Planet, Contract From Below, Inner Child, Box of Friends, Metal Plate, Mom's Ring, Breakfast, Spelunker Hat, Montezuma's Revenge, Quints, Sticky Bombs, Soul Locket, Glitter Bombs, Marrow, Prayer Card, Brittle Bones, Glyph of Balance, Telepathy for Dummies, Black Hole, Iron Bar, Midas' Touch, Mom's Eye, Caffeine Pill, Smart Fly, Hallowed Ground, Spider Bite, Bozo, Mercurius, Lil Monstro, Big Fan, Deep Pockets, Empty Vessel, Papa Fly, Lil Loki, Dad's Lost Coin, Sol, Sworn Protector, Smelter, Steven (Item), Immaculate Conception, Spear of Destiny, Taurus, Evil Charm, Purgatory, Loki's Horns, Buddy in a Box, No. 2, Ankh, D1, Brother Bobby, The Negative, Stitches, The Candle, Azazel's Rage, Card Reading, Anemic, Redemption, Isaac's Tomb, Number One, Bogo Bombs, Greed's Gullet, Harlequin Baby, Glowing Hourglass, Pandora's Box, Lunch, The Peeper, Mongo Baby, Cain's Other Eye, Suplex!, Epiphora, Rocket in a Jar, Bloody Gust, Skatole, ???'s Only Friend, Dream Catcher, Bomber Boy, The Book of Sin, Robo-Baby, Dark Prince's Crown, Sad Bombs, The Common Cold, Boom!, Anima Sola, Clear Rune, Evil Eye, Acid Baby, Recall, Lil Portal, D100, Shoop Da Whoop!, Halo of Flies, Magic Skin, Belly Button, Robo-Baby 2.0, Stye, Rainbow Baby, Vanishing Twin, Moving Box, Death's List, Sack of Pennies, Butt Bombs, Blood Clot, Eye of Greed, Larynx, Safety Pin, Guppy's Hair Ball, Venus, Boiled Baby, Zodiac, Stem Cells, Super Bandage, Monster Manual, Belly Jelly, Spiderbaby, Dad's Key, The Swarm, Berserk!, Little C.H.A.D., Box, Celtic Cross, Hive Mind, Latch Key, Spirit Shackles, Distant Admiration, The Ladder, Blood Bombs, Brimstone Bombs, A Quarter, Vengeful Spirit, Ghost Baby, King Baby, My Shadow, Mr. Mega, Varicose Veins, Finger!, Circle of Protection, Fast Bombs, Mystery Sack, Plum Flute, Deck of Cards, Crack Jacks, Bobby-Bomb, Black Powder, Giant Cell, Demon Baby, Lil Chest, Experimental Treatment, Cracked Orb, Juicy Sack, Bum Friend, Box of Spiders, Vade Retro, Hot Bombs, Large Zit, BBF, Sumptorium, Lil Gurdy, Key Piece 1, Lazarus' Rags, Bone Spurs, Bob's Curse, Tammy's Head, Lost Fly, Wooden Nickel, Aries, D4, Lil Delirium, The Virus, Telekinesis, Sister Maggy, Fortune Cookie, Lost Soul, Obsessed Fan, Bloodshot Eye, Head of Krampus, Dead Bird, Mom's Eyeshadow, Cube Baby, Match Book, Thunder Thighs, IV Bag, Fate's Reward, Placebo, Guardian Angel, Midnight Snack, Pageant Boy, Mom's Lipstick

D Tier

Fruity Plum, The Belt, Sack of Sacks, Jar of Wisps, My Little Unicorn, Jaw Bone, Wooden Spoon, Polydactyly, Anti-Gravity, Vasculitis, A Pound of Flesh, Teleport 2.0, 2Spooky, Ball of Bandages, Friend Zone, How to Jump, Bursting Sack, Booster Pack (Item), God's Flesh, Mystery Egg, Esau Jr., Supper, Hypercoagulation, Betrayal, Sanguine Bond, Abel, Lil Haunt, Night Light, Decap Attack, Mom's Wig, Bomb Bag, The Hourglass, Rotten Meat, Jupiter, Glaucoma, Ventricle Razor, Mom's Box, Potato Peeler, Magic Fingers, Converter, Mom's Coin Purse, Red Candle, Headless Baby, Piggy Bank, Mom's Razor, Crack the Sky, Isaac's Tears, Bucket of Lard, Bob's Brain, Ball of Tar, Empty Heart, Sharp Straw, Pay to Play, Leo, Dead Tooth, Hushy, Dull Razor, Glass Cannon, Key Bum, Best Bud, Keeper's Box, Friendly Ball, Tinytoma, Little Baggy, Dinner, Isaac's Heart, Guillotine, Little Gish, Breath of Life, Notched Axe, Pointy Rib, A Snack, Unicorn Stump, E. Coli, Candy Heart, Dessert, Strange Attractor, Missing Page 2, Mom's Bottle of Pills, Heartbreak, Broken Watch, Friend Finder, Undefined, Infestation, Shade, Lemon Mishap, Milk!, The Necronomicon, Samson's Chains, Mom's Underwear, Blood Oath, Little Chubby, Cursed Eye, D7, Angry Fly, Metronome, Akeldama, Dad's Note, <3, Depression, Eye Sore, Eraser, Battery Pack, Sprinkler, Mom's Bracelet, Razor Blade, Wavy Cap, Strawman, Yuck Heart, Plan C, The Pinking Shears, Nancy Bombs, Punching Bag, Dirty Mind, Missing No., Scissors, Mr. Boom, Bird Cage, GB Bug, Blood Rights, The Gamekid, Key Piece 2, Teleport!, Hemoptysis, Free Lemonade, Flush!, Portable Slot, Farting Baby, Doctor's Remote, Poke Go, Delirious, Forever Alone, Mom's Bra, Slipped Rib, Spider Butt, The Boomerang, TMTRAINER, Linger Bean, It Hurts, Dead Sea Scrolls, The Poop, D8, Magneto, Leprosy, Marked, Clicker, Tonsil, Wait What?, Remote Detonator, Mine Crafter, Hold, Mom's Heels, Best Friend, IBS, Lil Spewer, Mega Bean, Knife Piece 2, The Wiz, Big Chubby, Meat Cleaver, Brown Nugget, Tear Detonator, Bob's Rotten Head, The Bean, Blood Puppy, Shard of Glass, Kamikaze!, Mom's Shovel, Compost, Dataminer, Anarchist Cookbook, Sharp Key, Spin to Win, The Jar, D10, Monstro's Tooth, Jar of Flies, Pause, The Scooper, Keeper's Kin, D12, Broken Glass Cannon, Golden Razor, Kidney Bean, Broken Shovel, Curse of the Tower, Knife Piece 1, Bumbo, The Black Bean, Butter Bean

F Tier

Mom's Pad