The Best Secret Room Items Mood Board

67 Items

1.8K Votes

114 Voters

52%Consensus

Updated 4/24/26

A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 114 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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All 67 Secret Room Items Ranked, Best to Worst | The Binding of Isaac | Unduel