The Hardest Binding of Isaac Bosses - Hardest Rankings

103 Enemies

592 Votes

12 Voters

48%Consensus

Updated 1/26/26

A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 12 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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