The Hardest Binding of Isaac Bosses - Hardest Tier List

S

A

B

C

D

F

S Tier

Mega Satan

A Tier

The Visage, Delirium, Mother, Hush, The Scourge, Dogma, Ultra Greedier, Ultra Greed, Bumbino, Chimera, The Heretic, Min-Min, The Adversary

B Tier

Wormwood, Ultra War, The Lamb, Clutch, Ultra Pestilence, The Pile, Daddy Long Legs, Ultra Death, Rag Mega, Mask of Infamy, The Bloat, It Lives, The Rainmaker, The Stain, Mom, Rag Man, Satan, Singe, Gurdy Jr., Reap Creep, Colostomia, Mama Gurdy, Triachnid, The Cage, ??? (Boss), Dark One

C Tier

Carrion Queen, Peep, Scolex, Hornfel, Rotgut, Pestilence, Widow, Sisters Vis, Monstro II, Ultra Famine, Tuff Twins, Mom's Heart, The Haunt, The Beast, Teratoma, Turdlet, War, The Horny Boys, Steven, Great Gideon, Turdlings, The Frail, Dingle, Blighted Ovum, The Gate, The Wretched, Death (Boss), Fistula, Mega Maw, Famine, The Siren, Isaac (Boss), Dangle

D Tier

The Fallen, Mega Fatty, Gemini, C.H.A.D., Gurglings, Conquest, Mr. Fred, Chub, Baby Plum, The Matriarch, Gish, Clog, The Husk, Loki, Little Horn, Larry Jr., The Forsaken, The Shell, Big Horn, Lokii, Blastocyst, The Headless Horseman, Brownie, Pin, Monstro, Polycephalus, Lil Blub

F Tier

The Duke of Flies, The Hollow, Gurdy