The Hardest Binding of Isaac Bosses - Difficulty Rankings

103 Enemies

1.3K Votes

23 Voters

42%Consensus

Updated 2d ago

A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest. We combined votes from 23 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

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1.Mega Satan
1.Mega Satan
Chapter 6
Final Boss
Boss
100
Rating
76
CONS
100
Rating
76
CONS

2.Mother
2.Mother
Final Boss
Boss
Corpse
99
Rating
75
CONS
99
Rating
75
CONS

3.Delirium
3.Delirium
Final Boss
Boss
The Void
96
Rating
69
CONS
96
Rating
69
CONS

4.Hush
4.Hush
Final Boss
Boss
???
96
Rating
73
CONS
96
Rating
73
CONS

5.Dogma
5.Dogma
Final Boss
Boss
Home
92
Rating
68
CONS
92
Rating
68
CONS

6.Ultra Greedier
6.Ultra Greedier
Final Boss
Greed Mode
Boss
92
Rating
62
CONS
92
Rating
62
CONS

7.Ultra Greed
7.Ultra Greed
Final Boss
Greed Mode
Boss
83
Rating
53
CONS
83
Rating
53
CONS

8.The Visage
8.The Visage
Chapter 3.5
Boss
83
Rating
59
CONS
83
Rating
59
CONS

9.Bumbino
9.Bumbino
Chapter 2
Boss
76
Rating
60
CONS
76
Rating
60
CONS

10.It Lives
10.It Lives
Final Boss
Chapter 4
Boss
75
Rating
48
CONS
75
Rating
48
CONS

11.??? (Boss)
11.??? (Boss)
Chapter 6
Final Boss
Boss
74
Rating
52
CONS
74
Rating
52
CONS

12.The Bloat
12.The Bloat
Chapter 3
Boss
74
Rating
49
CONS
74
Rating
49
CONS

13.Ultra War
13.Ultra War
Boss
Home
71
Rating
48
CONS
71
Rating
48
CONS

14.Ultra Pestilence
14.Ultra Pestilence
Boss
Home
71
Rating
48
CONS
71
Rating
48
CONS

15.The Lamb
15.The Lamb
Chapter 6
Final Boss
Boss
70
Rating
54
CONS
70
Rating
54
CONS

16.Chimera
16.Chimera
Boss
Corpse
70
Rating
48
CONS
70
Rating
48
CONS

17.The Pile
17.The Pile
Chapter 2.5
Boss
70
Rating
52
CONS
70
Rating
52
CONS

18.The Heretic
18.The Heretic
Chapter 3.5
Boss
69
Rating
51
CONS
69
Rating
51
CONS

19.Satan
19.Satan
Chapter 5
Final Boss
Boss
69
Rating
53
CONS
69
Rating
53
CONS

20.The Scourge
20.The Scourge
Boss
Corpse
65
Rating
42
CONS
65
Rating
42
CONS

21.Daddy Long Legs
21.Daddy Long Legs
Chapter 4
Boss
65
Rating
43
CONS
65
Rating
43
CONS

22.The Adversary
22.The Adversary
Chapter 3
Boss
64
Rating
47
CONS
64
Rating
47
CONS

23.Clutch
23.Clutch
Chapter 2.5
Boss
64
Rating
46
CONS
64
Rating
46
CONS

24.Ultra Death
24.Ultra Death
Boss
Home
63
Rating
40
CONS
63
Rating
40
CONS

25.Isaac (Boss)
25.Isaac (Boss)
Chapter 5
Final Boss
Boss
59
Rating
45
CONS
59
Rating
45
CONS

26.The Beast
26.The Beast
Final Boss
Boss
Home
58
Rating
48
CONS
58
Rating
48
CONS

27.Rag Mega
27.Rag Mega
Chapter 2
Boss
57
Rating
42
CONS
57
Rating
42
CONS

28.Mom
28.Mom
Final Boss
Chapter 3
Boss
57
Rating
36
CONS
57
Rating
36
CONS

29.Mom's Heart
29.Mom's Heart
Final Boss
Chapter 3.5
Boss
56
Rating
40
CONS
56
Rating
40
CONS

30.Reap Creep
30.Reap Creep
Chapter 2.5
Boss
55
Rating
39
CONS
55
Rating
39
CONS

31.Pestilence
31.Pestilence
Chapter 2
Boss
55
Rating
39
CONS
55
Rating
39
CONS

32.Colostomia
32.Colostomia
Chapter 1.5
Boss
54
Rating
37
CONS
54
Rating
37
CONS

33.Min-Min
33.Min-Min
Chapter 1.5
Boss
54
Rating
35
CONS
54
Rating
35
CONS

34.The Stain
34.The Stain
Chapter 2
Boss
54
Rating
39
CONS
54
Rating
39
CONS

35.Mask of Infamy
35.Mask of Infamy
Chapter 3
Boss
53
Rating
39
CONS
53
Rating
39
CONS

36.Hornfel
36.Hornfel
Chapter 2.5
Boss
52
Rating
37
CONS
52
Rating
37
CONS

37.Singe
37.Singe
Chapter 2.5
Boss
51
Rating
37
CONS
51
Rating
37
CONS

38.Gurdy Jr.
38.Gurdy Jr.
Chapter 2
Boss
50
Rating
34
CONS
50
Rating
34
CONS

39.Triachnid
39.Triachnid
Chapter 4
Boss
50
Rating
35
CONS
50
Rating
35
CONS

40.Rotgut
40.Rotgut
Boss
Corpse
49
Rating
28
CONS
49
Rating
28
CONS

41.Death (Boss)
41.Death (Boss)
Chapter 4
Boss
49
Rating
34
CONS
49
Rating
34
CONS

42.Dark One
42.Dark One
Chapter 2
Boss
48
Rating
32
CONS
48
Rating
32
CONS

43.Sisters Vis
43.Sisters Vis
Chapter 3
Boss
47
Rating
32
CONS
47
Rating
32
CONS

44.Wormwood
44.Wormwood
Chapter 1.5
Boss
47
Rating
36
CONS
47
Rating
36
CONS

45.Carrion Queen
45.Carrion Queen
Chapter 2
Boss
45
Rating
34
CONS
45
Rating
34
CONS

46.Tuff Twins
46.Tuff Twins
Chapter 2.5
Boss
45
Rating
32
CONS
45
Rating
32
CONS

47.Monstro II
47.Monstro II
Chapter 3
Boss
44
Rating
35
CONS
44
Rating
35
CONS

48.Conquest
48.Conquest
Chapter 4
Boss
43
Rating
32
CONS
43
Rating
32
CONS

49.Rag Man
49.Rag Man
Chapter 1
Boss
43
Rating
29
CONS
43
Rating
29
CONS

50.The Cage
50.The Cage
Chapter 3
Boss
43
Rating
33
CONS
43
Rating
33
CONS

51.Scolex
51.Scolex
Chapter 4
Boss
42
Rating
29
CONS
42
Rating
29
CONS

52.Ultra Famine
52.Ultra Famine
Boss
Home
42
Rating
33
CONS
42
Rating
33
CONS

53.Widow
53.Widow
Chapter 1
Boss
41
Rating
38
CONS
41
Rating
38
CONS

54.The Rainmaker
54.The Rainmaker
Chapter 1.5
Boss
41
Rating
29
CONS
41
Rating
29
CONS

55.The Fallen
55.The Fallen
Boss
38
Rating
30
CONS
38
Rating
30
CONS

56.War
56.War
Chapter 3
Boss
37
Rating
31
CONS
37
Rating
31
CONS

57.The Frail
57.The Frail
Chapter 2
Boss
37
Rating
31
CONS
37
Rating
31
CONS

58.Mama Gurdy
58.Mama Gurdy
Chapter 4
Boss
37
Rating
31
CONS
37
Rating
31
CONS

59.The Horny Boys
59.The Horny Boys
Chapter 3.5
Boss
37
Rating
35
CONS
37
Rating
35
CONS

60.The Forsaken
60.The Forsaken
Chapter 2
Boss
36
Rating
35
CONS
36
Rating
35
CONS

61.The Matriarch
61.The Matriarch
Chapter 4
Boss
36
Rating
30
CONS
36
Rating
30
CONS

62.The Haunt
62.The Haunt
Chapter 1
Boss
35
Rating
29
CONS
35
Rating
29
CONS

63.The Wretched
63.The Wretched
Chapter 2
Boss
35
Rating
36
CONS
35
Rating
36
CONS

64.Great Gideon
64.Great Gideon
Chapter 2.5
Boss
33
Rating
38
CONS
33
Rating
38
CONS

65.Lil Blub
65.Lil Blub
Chapter 1.5
Boss
33
Rating
31
CONS
33
Rating
31
CONS

66.Clog
66.Clog
Chapter 1.5
Boss
33
Rating
30
CONS
33
Rating
30
CONS

67.Lokii
67.Lokii
Chapter 4
Boss
33
Rating
32
CONS
33
Rating
32
CONS

68.Famine
68.Famine
Chapter 1
Boss
33
Rating
31
CONS
33
Rating
31
CONS

69.Turdlet
69.Turdlet
Chapter 1.5
Boss
31
Rating
33
CONS
31
Rating
33
CONS

70.Peep
70.Peep
Chapter 2
Boss
30
Rating
37
CONS
30
Rating
37
CONS

71.The Gate
71.The Gate
Chapter 3
Boss
30
Rating
30
CONS
30
Rating
30
CONS

72.Steven
72.Steven
Chapter 1
Boss
30
Rating
30
CONS
30
Rating
30
CONS

73.The Siren
73.The Siren
Chapter 3.5
Boss
29
Rating
42
CONS
29
Rating
42
CONS

74.Mega Maw
74.Mega Maw
Chapter 2
Boss
29
Rating
31
CONS
29
Rating
31
CONS

75.Baby Plum
75.Baby Plum
Chapter 1
Boss
28
Rating
31
CONS
28
Rating
31
CONS

76.Dingle
76.Dingle
Chapter 1
Boss
28
Rating
30
CONS
28
Rating
30
CONS

77.Mr. Fred
77.Mr. Fred
Chapter 4
Boss
27
Rating
33
CONS
27
Rating
33
CONS

78.Blighted Ovum
78.Blighted Ovum
Chapter 1
Boss
26
Rating
29
CONS
26
Rating
29
CONS

79.Dangle
79.Dangle
Chapter 1
Boss
25
Rating
37
CONS
25
Rating
37
CONS

80.Mega Fatty
80.Mega Fatty
Chapter 2
Boss
24
Rating
34
CONS
24
Rating
34
CONS

81.Brownie
81.Brownie
Chapter 3
Boss
24
Rating
38
CONS
24
Rating
38
CONS

82.The Shell
82.The Shell
Chapter 2.5
Boss
24
Rating
41
CONS
24
Rating
41
CONS

83.Gurglings
83.Gurglings
Chapter 1
Boss
24
Rating
34
CONS
24
Rating
34
CONS

84.Turdlings
84.Turdlings
Chapter 1
Boss
23
Rating
41
CONS
23
Rating
41
CONS

85.Little Horn
85.Little Horn
Chapter 1
Boss
22
Rating
33
CONS
22
Rating
33
CONS

86.Fistula
86.Fistula
Chapter 2
Boss
22
Rating
37
CONS
22
Rating
37
CONS

87.Gish
87.Gish
Chapter 3
Boss
20
Rating
39
CONS
20
Rating
39
CONS

88.Gemini
88.Gemini
Chapter 1
Boss
20
Rating
36
CONS
20
Rating
36
CONS

89.Big Horn
89.Big Horn
Chapter 2
Boss
20
Rating
40
CONS
20
Rating
40
CONS

90.Loki
90.Loki
Chapter 3
Boss
19
Rating
41
CONS
19
Rating
41
CONS

91.Chub
91.Chub
Chapter 2
Boss
19
Rating
41
CONS
19
Rating
41
CONS

92.The Husk
92.The Husk
Chapter 2
Boss
18
Rating
40
CONS
18
Rating
40
CONS

93.C.H.A.D.
93.C.H.A.D.
Chapter 2
Boss
17
Rating
40
CONS
17
Rating
40
CONS

94.Monstro
94.Monstro
Chapter 1
Boss
14
Rating
41
CONS
14
Rating
41
CONS

95.Teratoma
95.Teratoma
Chapter 4
Boss
14
Rating
45
CONS
14
Rating
45
CONS

96.Blastocyst
96.Blastocyst
Chapter 4
Boss
10
Rating
50
CONS
10
Rating
50
CONS

97.Polycephalus
97.Polycephalus
Chapter 2
Boss
9
Rating
53
CONS
9
Rating
53
CONS

98.Pin
98.Pin
Chapter 1
Boss
9
Rating
48
CONS
9
Rating
48
CONS

99.The Headless Horseman
99.The Headless Horseman
Boss
9
Rating
53
CONS
9
Rating
53
CONS

100.Larry Jr.
100.Larry Jr.
Chapter 1
Boss
6
Rating
52
CONS
6
Rating
52
CONS

101.Gurdy
101.Gurdy
Chapter 2
Boss
6
Rating
56
CONS
6
Rating
56
CONS

102.The Hollow
102.The Hollow
Chapter 2
Boss
2
Rating
61
CONS
2
Rating
61
CONS

103.The Duke of Flies
103.The Duke of Flies
Chapter 1
Boss
0
Rating
60
CONS
0
Rating
60
CONS