The Hardest Binding of Isaac Bosses - Difficulty Rankings

103 Enemies

776 Votes

16 Voters

45%Consensus

Updated 8/5/26

A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest. We combined votes from 16 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

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