The Hardest Final Bosses - Hardest Tier List

15 Enemies

110 Votes

9 Voters

51%Consensus

Updated 1/26/26

A list of all final bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 9 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

Sort by

Filter by

S

A

B

C

D

F