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The Best Secret Room Items Ranked List

67 Items1.5K Votes96 Voters
Updated November 9, 2025
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A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 96 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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All 67 Secret Room Items Ranked, Best to Worst | The Binding of Isaac | Unduel