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The Best Secret Room Items

A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 86 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

Rankings updated September 2, 2025.
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67 Items

1.2K  Votes

86  Voters

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All 67 Secret Room Items Ranked, Best to Worst | The Binding of Isaac | Unduel