The Best Secret Room Items Ranked List

67 Items

1.8K Votes

113 Voters

52%Consensus

Updated 3/23/26

A list of all secret room items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 113 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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1.Death Certificate
1.Death Certificate
Secret Room
Quality 4
Activated
88
100
Rating
84
CONS
88
100
Rating
84
CONS

2.Glitched Crown
2.Glitched Crown
Passive
Secret Room
Quality 4
91
97
Rating
71
CONS
91
97
Rating
71
CONS

3.Sacred Orb
3.Sacred Orb
Angel Room
Passive
Secret Room
Quality 4
91
89
Rating
57
CONS
91
89
Rating
57
CONS

4.R Key
4.R Key
Secret Room
Quality 4
Activated
89
88
Rating
56
CONS
89
88
Rating
56
CONS

5.Spindown Dice
5.Spindown Dice
Treasure Room
Secret Room
Quality 4
Activated
Crane Game
89
87
Rating
56
CONS
89
87
Rating
56
CONS

6.D Infinity
6.D Infinity
Treasure Room
Secret Room
Quality 4
Activated
90
82
Rating
51
CONS
90
82
Rating
51
CONS

7.Red Key
7.Red Key
Quality 3
Ultra Secret Room
Secret Room
Activated
Key Master
Curse Room
Red Chest
16
79
Rating
61
CONS
16
79
Rating
61
CONS

8.Rock Bottom
8.Rock Bottom
Quality 3
Passive
Secret Room
16
78
Rating
57
CONS
16
78
Rating
57
CONS

9.Eternal D6
9.Eternal D6
Quality 3
Treasure Room
Secret Room
Activated
Crane Game
15
76
Rating
60
CONS
15
76
Rating
60
CONS

10.Chaos
10.Chaos
Quality 3
Passive
Secret Room
Shop
19
72
Rating
55
CONS
19
72
Rating
55
CONS

11.Sausage
11.Sausage
Quality 3
Passive
Secret Room
18
65
Rating
44
CONS
18
65
Rating
44
CONS

12.Lost Contact
12.Lost Contact
Quality 2
Passive
Treasure Room
Secret Room
15
58
Rating
37
CONS
15
58
Rating
37
CONS

13.Mega Mush
13.Mega Mush
Treasure Room
Secret Room
Quality 4
Activated
92
57
Rating
57
CONS
92
57
Rating
57
CONS

14.Flip
14.Flip
Ultra Secret Room
Secret Room
Quality 4
Activated
Curse Room
87
57
Rating
56
CONS
87
57
Rating
56
CONS

15.Binge Eater
15.Binge Eater
Passive
Secret Room
Quality 4
88
56
Rating
61
CONS
88
56
Rating
61
CONS

16.Blank Card
16.Blank Card
Quality 2
Treasure Room
Secret Room
Activated
Shop
14
52
Rating
41
CONS
14
52
Rating
41
CONS

17.1up!
17.1up!
Quality 2
Passive
Secret Room
15
52
Rating
39
CONS
15
52
Rating
39
CONS

18.Forget Me Now
18.Forget Me Now
Quality 3
Treasure Room
Secret Room
Activated
Devil Beggar
Devil Room
19
50
Rating
48
CONS
19
50
Rating
48
CONS

19.Infamy
19.Infamy
Quality 2
Passive
Treasure Room
Secret Room
Golden Chest
18
48
Rating
45
CONS
18
48
Rating
45
CONS

20.We Need to Go Deeper!
20.We Need to Go Deeper!
Quality 2
Secret Room
Activated
Devil Room
20
48
Rating
41
CONS
20
48
Rating
41
CONS

21.Odd Mushroom (Large)
21.Odd Mushroom (Large)
Quality 2
Passive
Treasure Room
Secret Room
16
46
Rating
35
CONS
16
46
Rating
35
CONS

22.Sack Head
22.Sack Head
Quality 3
Passive
Secret Room
Shop
17
46
Rating
34
CONS
17
46
Rating
34
CONS

23.Pyro
23.Pyro
Quality 3
Passive
Treasure Room
Secret Room
Bomb Bum
16
45
Rating
42
CONS
16
45
Rating
42
CONS

24.Echo Chamber
24.Echo Chamber
Quality 3
Passive
Ultra Secret Room
Secret Room
17
45
Rating
32
CONS
17
45
Rating
32
CONS

25.Astral Projection
25.Astral Projection
Quality 2
Passive
Treasure Room
Secret Room
13
44
Rating
34
CONS
13
44
Rating
34
CONS

26.Skeleton Key
26.Skeleton Key
Quality 3
Passive
Treasure Room
Secret Room
17
43
Rating
38
CONS
17
43
Rating
38
CONS

27.Keeper's Sack
27.Keeper's Sack
Quality 3
Passive
Secret Room
Shop
16
42
Rating
36
CONS
16
42
Rating
36
CONS

28.Black Lotus
28.Black Lotus
Quality 2
Passive
Secret Room
14
42
Rating
42
CONS
14
42
Rating
42
CONS

29.Rune Bag
29.Rune Bag
Quality 3
Passive
Treasure Room
Secret Room
Golden Chest
14
41
Rating
41
CONS
14
41
Rating
41
CONS

30.Transcendence
30.Transcendence
Quality 3
Passive
Secret Room
16
41
Rating
37
CONS
16
41
Rating
37
CONS

31.Book of Secrets
31.Book of Secrets
Quality 1
Treasure Room
Secret Room
Activated
Library
14
38
Rating
35
CONS
14
38
Rating
35
CONS

32.Epic Fetus
32.Epic Fetus
Passive
Treasure Room
Secret Room
Quality 4
88
38
Rating
68
CONS
88
38
Rating
68
CONS

33.Dad's Ring
33.Dad's Ring
Quality 3
Passive
Old Chest
Secret Room
15
38
Rating
36
CONS
15
38
Rating
36
CONS

34.Odd Mushroom (Thin)
34.Odd Mushroom (Thin)
Quality 2
Passive
Treasure Room
Secret Room
19
37
Rating
36
CONS
19
37
Rating
36
CONS

35.Orphan Socks
35.Orphan Socks
Quality 2
Passive
Secret Room
Golden Chest
17
37
Rating
36
CONS
17
37
Rating
36
CONS

36.Vanishing Twin
36.Vanishing Twin
Quality 2
Passive
Secret Room
Curse Room
14
33
Rating
31
CONS
14
33
Rating
31
CONS

37.Inner Child
37.Inner Child
Quality 2
Passive
Secret Room
14
32
Rating
34
CONS
14
32
Rating
34
CONS

38.Raw Liver
38.Raw Liver
Quality 2
Passive
Secret Room
14
32
Rating
38
CONS
14
32
Rating
38
CONS

39.Evil Charm
39.Evil Charm
Quality 2
Passive
Secret Room
12
31
Rating
34
CONS
12
31
Rating
34
CONS

40.Isaac's Tomb
40.Isaac's Tomb
Quality 3
Passive
Secret Room
15
31
Rating
25
CONS
15
31
Rating
25
CONS

41.Eye of Greed
41.Eye of Greed
Quality 2
Passive
Secret Room
15
31
Rating
34
CONS
15
31
Rating
34
CONS

42.Mystery Sack
42.Mystery Sack
Quality 2
Passive
Treasure Room
Beggar
Secret Room
Golden Chest
19
30
Rating
33
CONS
19
30
Rating
33
CONS

43.Greed's Gullet
43.Greed's Gullet
Passive
Quality 1
Secret Room
15
30
Rating
35
CONS
15
30
Rating
35
CONS

44.Clear Rune
44.Clear Rune
Quality 2
Secret Room
Activated
Crane Game
14
28
Rating
39
CONS
14
28
Rating
39
CONS

45.Spirit Shackles
45.Spirit Shackles
Quality 2
Passive
Secret Room
15
26
Rating
37
CONS
15
26
Rating
37
CONS

46.Cracked Orb
46.Cracked Orb
Passive
Quality 1
Treasure Room
Secret Room
16
25
Rating
35
CONS
16
25
Rating
35
CONS

47.A Quarter
47.A Quarter
Passive
Treasure Room
Quality 0
Secret Room
Devil Room
Golden Chest
24
25
Rating
47
CONS
24
25
Rating
47
CONS

48.Sack of Pennies
48.Sack of Pennies
Passive
Quality 1
Treasure Room
Secret Room
Golden Chest
16
25
Rating
37
CONS
16
25
Rating
37
CONS

49.Mr. Mega
49.Mr. Mega
Quality 2
Passive
Treasure Room
Secret Room
Bomb Bum
14
23
Rating
42
CONS
14
23
Rating
42
CONS

50.Lost Soul
50.Lost Soul
Quality 2
Passive
Baby Shop
Treasure Room
Secret Room
14
22
Rating
35
CONS
14
22
Rating
35
CONS

51.Sack of Sacks
51.Sack of Sacks
Quality 3
Passive
Secret Room
Shop
Golden Chest
17
21
Rating
44
CONS
17
21
Rating
44
CONS

52.Placebo
52.Placebo
Quality 2
Secret Room
Activated
Shop
15
20
Rating
41
CONS
15
20
Rating
41
CONS

53.Keeper's Box
53.Keeper's Box
Quality 2
Secret Room
Activated
Wooden Chest
Shop
13
18
Rating
52
CONS
13
18
Rating
52
CONS

54.Key Bum
54.Key Bum
Passive
Baby Shop
Treasure Room
Quality 0
Secret Room
Key Master
15
17
Rating
39
CONS
15
17
Rating
39
CONS

55.Wavy Cap
55.Wavy Cap
Quality 1
Secret Room
Activated
14
17
Rating
39
CONS
14
17
Rating
39
CONS

56.Esau Jr.
56.Esau Jr.
Quality 2
Ultra Secret Room
Treasure Room
Secret Room
Activated
13
16
Rating
40
CONS
13
16
Rating
40
CONS

57.Missing No.
57.Missing No.
Passive
Quality 0
Secret Room
11
15
Rating
42
CONS
11
15
Rating
42
CONS

58.Cursed Eye
58.Cursed Eye
Passive
Treasure Room
Quality 0
Secret Room
Red Chest
14
14
Rating
42
CONS
14
14
Rating
42
CONS

59.Bomb Bag
59.Bomb Bag
Quality 2
Passive
Treasure Room
Secret Room
Bomb Bum
Golden Chest
16
13
Rating
49
CONS
16
13
Rating
49
CONS

60.Missing Page 2
60.Missing Page 2
Passive
Quality 0
Secret Room
Devil Beggar
Devil Room
21
12
Rating
47
CONS
21
12
Rating
47
CONS

61.TMTRAINER
61.TMTRAINER
Passive
Quality 0
Secret Room
13
12
Rating
45
CONS
13
12
Rating
45
CONS

62.Strawman
62.Strawman
Quality 2
Passive
Secret Room
15
12
Rating
44
CONS
15
12
Rating
44
CONS

63.Samson's Chains
63.Samson's Chains
Passive
Quality 1
Treasure Room
Secret Room
20
12
Rating
49
CONS
20
12
Rating
49
CONS

64.The Necronomicon
64.The Necronomicon
Quality 1
Secret Room
Activated
Library
Devil Room
20
11
Rating
51
CONS
20
11
Rating
51
CONS

65.GB Bug
65.GB Bug
Passive
Quality 1
Treasure Room
Secret Room
13
8
Rating
50
CONS
13
8
Rating
50
CONS

66.Compost
66.Compost
Quality 1
Secret Room
Activated
Shop
Rotten Beggar
14
7
Rating
52
CONS
14
7
Rating
52
CONS

67.Keeper's Kin
67.Keeper's Kin
Quality 2
Passive
Treasure Room
Secret Room
12
0
Rating
60
CONS
12
0
Rating
60
CONS