The Best Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Holy Grail, Red Key, Sacred Heart, Death Certificate, Car Battery, Glitched Crown, Dead Dove, Mucormycosis, Eden's Blessing, Mama Mega!, Apple!, Spoon Bender, The Halo

A Tier

SMB Super Fan, Latch Key, Binky, More Options, Rock Bottom, Host Hat, Bag of Crafting, Technology, PJs, Fruit Cake, Eternal D6, Chaos, Holy Light, Goat Head, Jacob's Ladder, C Section, Blood of the Martyr, Book of Shadows, Diplopia, Glass Eye, Eucharist, Sharp Plug, The Mind, A Lump of Coal, 8 Inch Nails, Ceremonial Robes, Black Candle, The Small Rock, Head of the Keeper, Tough Love, Twisted Pair, Mutant Spider, Mr. Dolly, Sacred Orb, Athame, Technology Zero, Adrenaline, R Key, Mom's Pearls, The D6, D20, Placenta, Ghost Pepper, Little Horn (Item), Lemegeton, Sinus Infection, Mom's Knife, The Sad Onion, Explosivo, Cat-O-Nine-Tails, Spindown Dice, Growth Hormones, Godhead, White Pony, Trisagion, Technology 2, Book of Virtues, Holy Mantle, Birthright, Shoop Da Whoop!, Spirit Sword, Champion Belt, Playdough Cookie, Fire Mind, Tooth Picks, Wire Coat Hanger, Abaddon, A Dollar, Red Stew, Yum Heart, Blank Card, Mystery Gift, The Parasite, Euthanasia, Pupula Duplex, Book of Revelations, Lodestone, Rubber Cement, The Intruder, Humbleing Bundle, Tech X, Lil Dumpy, D Infinity, Toxic Shock, Serpent's Kiss, Mom's Perfume, The Mark, Camo Undies, Dark Arts, Monstro's Lung, Tractor Beam, Blood Bag, Genesis, Dead Eye, Crooked Penny, Eden's Soul, Box of Friends, The Pact

B Tier

Proptosis, Montezuma's Revenge, Brittle Bones, Glitter Bombs, Sausage, Angelic Prism, Scorpio, Fate, Rotten Baby, Sulfur, Tropicamide, Saturnus, The Body, The Virus, Tarot Cloth, Dark Matter, The Soul, Dogma (Item), Mom's Contacts, Pluto, Big Fan, Divorce Papers, Wooden Nickel, Mega Bean, Blue Map, Treasure Map, Ocular Rift, Worm Friend, Eve's Mascara, Censer, The Stairway, Gnawed Leaf, Act of Contrition, Mysterious Liquid, Gello, Contract From Below, Almond Milk, The Inner Eye, Bob's Curse, BFFS!, Transcendence, MEAT!, Card Reading, Rosary, Bozo, Mr. ME!, Black Hole, Guppy's Eye, My Reflection, Immaculate Heart, Aquarius, Sulfuric Acid, Bot Fly, Lil Portal, Leech, Rune Bag, Mitre, Keeper's Box, Holy Water, Lusty Blood, Neptunus, Eye of the Occult, YO LISTEN!, The Bible, Tooth and Nail, Paschal Candle, Magic Skin, Steam Sale, Dead Tooth, Guppy's Collar, Salvation, Bobby-Bomb, Cancer, Echo Chamber, 4.5 Volt, Death's Touch, Lost Contact, Spider Mod, Lil Monstro, Metal Plate, Brimstone, Ventricle Razor, The Peeper, Chocolate Milk, Varicose Veins, The Candle, Fast Bombs, Contagion, Duality, Cricket's Body, The Relic, Mr. Mega, Pyro, The Ludovico Technique, Suplex!, Sumptorium, Stem Cells, My Shadow, Cube of Meat, Incubus, Cain's Other Eye, Bomber Boy, Psy Fly, Pop!, Papa Fly, Cricket's Head, Odd Mushroom (Large), Guillotine, Deck of Cards, Mom's Eye, Polydactyly, Magic Scab, Jaw Bone, Forget Me Now, 9 Volt, Mom's Ring, Capricorn, Dry Baby, Lil Abaddon, Gimpy, Lachryphagy, Habit, Blanket, Bird's Eye, Mom's Key, Money = Power, Prayer Card, 7 Seals, Infamy, Soul Locket, Golden Razor, We Need to Go Deeper!, Black Lotus, Libra, Roid Rage, Eye of Belial, Magic Mushroom, Fanny Pack, D7, Crown of Light, PHD, Stigmata, Soy Milk, Vanishing Twin, Teleport 2.0, Damocles, Hive Mind, Member Card, A Pony, Sticky Bombs, Schoolbag, Whore of Babylon, Everything Jar, Night Light, Revelation, Pyromaniac, Deep Pockets, Sissy Longlegs, Astral Projection, Virgo, The Wafer, Finger!, Maw of the Void, Spirit of the Night, Succubus, Lunch, Sad Bombs, Halo of Flies, Moving Box, The Common Cold, Dad's Ring, Pentagram, Head of Krampus, Stop Watch, Tech.5, Dad's Key, Empty Vessel, Boom!, Sacrificial Altar, Alabaster Box, Binge Eater, Mega Mush, Match Book, Book of the Dead, Mystery Sack, Lil Loki, Starter Deck, Bogo Bombs, The Battery, Potato Peeler

C Tier

Seraphim, Spiderbaby, Urn of Souls, Luna, Lucky Foot, Divine Intervention, Harlequin Baby, Knockout Drops, Options?, Larynx, X-Ray Vision, Smelter, Spirit Shackles, Mom's Lipstick, Jumper Cables, Lemon Mishap, Marrow, Backstabber, Tiny Planet, 3 Dollar Bill, Spear of Destiny, Dead Cat, Torn Photo, Crack the Sky, Terra, Sworn Protector, Raw Liver, Flat Stone, Redemption, Dark Bum, Blood Rights, Keeper's Sack, Lil Brimstone, There's Options, IV Bag, Cone Head, Glaucoma, Caffeine Pill, Dead Bird, Key Piece 1, Monstro's Tooth, The Book of Belial, Sharp Straw, Box of Spiders, The Nail, Cambion Conception, Synthoil, Isaac's Tears, A Bar of Soap, Flip, Lead Pencil, Loki's Horns, Scapular, D1, Giant Cell, Crystal Ball, Voodoo Head, Speed Ball, Sacrificial Dagger, Immaculate Conception, Sack of Pennies, Daddy Longlegs, Magic 8 Ball, Glowing Hourglass, Scatter Bombs, Gemini (Item), Magic Fingers, Rainbow Baby, Freezer Baby, Jar of Wisps, Eye Sore, Guppy's Paw, Little Steven, Guppy's Head, Marbles, Compound Fracture, Jesus Juice, Blue Cap, My Little Unicorn, Skeleton Key, Azazel's Rage, Guppy's Tail, Plum Flute, Stapler, Orphan Socks, Analog Stick, Butt Bombs, Kidney Stone, Little C.H.A.D., The Mulligan, Dog Tooth, Guardian Angel, Restock, Odd Mushroom (Thin), Purity, Judas' Shadow, Brother Bobby, Rocket in a Jar, Circle of Protection, The Polaroid, Stye, Sack Head, How to Jump, Consolation Prize, Screw, Experimental Treatment, 20/20, BBF, Coupon, Pointy Rib, Mom's Purse, Mini Mush, Hallowed Ground, Trinity Shield, Multidimensional Baby, Doctor's Remote, Greed's Gullet, Cube Baby, Pisces, Sol, Parasitoid, Bum Friend, Mars, Monstrance, Eye Drops, Breakfast, Teleport!, The Belt, Super Bandage, Blood Clot, Decap Attack, Plan C, Chemical Peel, Magneto, Polyphemus, Bloody Lust, Isaac's Tomb, No. 2, Haemolacria, Bloodshot Eye, Book of Secrets, Dead Onion, Charm of the Vampire, Boiled Baby, Jupiter, Squeezy, A Pound of Flesh, ???'s Only Friend, Little Baggy, Ghost Bombs, The Book of Sin, Friend Finder, Best Bud, Demon Baby, Uranus, Cracked Orb, The Compass, Venus, Best Friend, False PHD, Quints, Dataminer, Poke Go, Eraser, Lord of the Pit, Blood Bombs, Box, Telekinesis, Stitches, Anima Sola, Evil Eye, Safety Pin, Robo-Baby, Pandora's Box, Number One, Clear Rune, Infestation 2, Skatole, Isaac's Heart, Mom's Underwear, Evil Charm, Rotten Tomato, Midas' Touch, 120 Volt, The Scooper, Little Chubby, 1up!, Free Lemonade, Scissors, Distant Admiration, Steven (Item), Old Bandage, Mystery Egg, Purgatory, Ouija Board, Void, Iron Bar, Berserk!, Inner Child, Satanic Bible, Rotten Meat, Hypercoagulation, D4, Lil Delirium, Wooden Spoon, Broken Watch, Sagittarius, Hungry Soul, Bird Cage, Bomb Bag, 2Spooky, Ipecac

D Tier

Maggy's Bow, Razor Blade, Vengeful Spirit, Glyph of Balance, Guppy's Hair Ball, Eye of Greed, Star of Bethlehem, Pay to Play, Empty Heart, The Swarm, Nancy Bombs, Mom's Wig, Yuck Heart, Cursed Eye, The Ladder, King Baby, Sack of Sacks, Portable Slot, Key Piece 2, D100, Ball of Bandages, The Jar, Buddy in a Box, Dinner, Candy Heart, Abyss, Broken Glass Cannon, Lil Gurdy, Midnight Snack, The Negative, Wavy Cap, Hot Bombs, Heartbreak, Brimstone Bombs, Crack Jacks, Fate's Reward, Mega Blast, Notched Axe, Breath of Life, Little Gish, Mom's Bra, Strawman, Continuum, Lil Chest, Sharp Key, Belly Jelly, Pageant Boy, Cupid's Arrow, Flush!, Dr. Fetus, Anti-Gravity, Booster Pack (Item), Mom's Razor, The Wiz, The Boomerang, Bloody Gust, D12, Mercurius, Zodiac, Epic Fetus, Dull Razor, Supper, Shard of Glass, Slipped Rib, Knife Piece 2, Akeldama, Abel, Placebo, Monster Manual, Lost Soul, Leo, Dark Prince's Crown, It Hurts, Aries, Vasculitis, Blood Oath, Lazarus' Rags, Mr. Boom, Charged Baby, Bursting Sack, Taurus, The Poop, Bucket of Lard, A Quarter, Mom's Box, The Hourglass, Unicorn Stump, Belly Button, Robo-Baby 2.0, Spin to Win, Dream Catcher, Tammy's Head, Mom's Eyeshadow, Broken Modem, Undefined, Recall, Mom's Bottle of Pills, Dad's Lost Coin, Juicy Sack, Tear Detonator, Betrayal, Missing Page 2, Spelunker Hat, D8, Vade Retro, Glass Cannon, Curse of the Tower, Death's List, Esau Jr., Remote Detonator, Bob's Rotten Head, Lil Haunt, Ghost Baby, Samson's Chains, Dessert, Wait What?, Hushy, Sanguine Bond, Fortune Cookie, Ankh, Anemic, Marked, Dead Sea Scrolls, Acid Baby, Red Candle, Black Powder, Headless Baby, Metronome, Fruity Plum, Friendly Ball, E. Coli, Depression, Missing No., Converter, Epiphora, Piggy Bank, Pause, Punching Bag, Obsessed Fan, Ball of Tar, Kidney Bean, Forever Alone, Smart Fly, Battery Pack, Hemoptysis, Telepathy for Dummies, Sister Maggy, <3, Spider Butt, Shade, Thunder Thighs, Large Zit, Spider Bite, D10, Leprosy, Bumbo, Meat Cleaver, The Pinking Shears, Strange Attractor, A Snack, Celtic Cross, Infestation, Compost, Lil Spewer, Mom's Pad, Friend Zone, Dad's Note

F Tier

Hold, Milk!, The Bean, Sprinkler, The Necronomicon, Anarchist Cookbook, Dirty Mind, The Gamekid, Farting Baby, Bone Spurs, Delirious, Clicker, Tinytoma, Mom's Coin Purse, Broken Shovel, Angry Fly, Mom's Shovel, Key Bum, Brown Nugget, God's Flesh, Lost Fly, IBS, Keeper's Kin, GB Bug, Tonsil, Mom's Heels, TMTRAINER, Big Chubby, Mom's Bracelet, Jar of Flies, Mongo Baby, Knife Piece 1, Linger Bean, Kamikaze!, Butter Bean, Bob's Brain, Mine Crafter, The Black Bean, Blood Puppy