The Best Binding of Isaac Items Tier List

S

A

B

C

D

F

S Tier

Death Certificate, Sacred Heart, Red Key, Glitched Crown, Apple!

A Tier

SMB Super Fan, More Options, Eternal D6, Goat Head, Rock Bottom, Technology, Binky, Jacob's Ladder, Spoon Bender, Host Hat, C Section, Athame, Fruit Cake, Mutant Spider, A Lump of Coal, Diplopia, Car Battery, Mucormycosis, Birthright, Eden's Blessing, Twisted Pair, Black Candle, Technology Zero, Book of Shadows, Holy Light, Bag of Crafting, Tough Love, Sacred Orb, Sharp Plug, Ceremonial Robes, White Pony, 8 Inch Nails, Chaos, Trisagion, The D6, Mama Mega!, R Key, Godhead, Sinus Infection, Book of Virtues, Ghost Pepper, Head of the Keeper, Spindown Dice, Mom's Knife, The Small Rock, The Mind, Explosivo, Mr. Dolly, Glass Eye, The Halo, Holy Mantle, Growth Hormones, Cat-O-Nine-Tails, Blood of the Martyr, Eucharist, Mom's Pearls, Mystery Gift, Placenta, The Sad Onion, Euthanasia, Technology 2, The Parasite, Little Horn (Item), Fire Mind, Shoop Da Whoop!, Lemegeton, Champion Belt, Rubber Cement, Tooth Picks, PJs, Holy Grail, Playdough Cookie, A Dollar, Spirit Sword, Lodestone, Wire Coat Hanger, Red Stew, Yum Heart, The Stairway, Tractor Beam, Dead Dove, Tech X, Humbleing Bundle, Monstro's Lung, Sausage, Lil Dumpy, The Mark, D20, Latch Key, D Infinity, Blank Card, Mom's Perfume, Dark Arts, Fate, Dead Eye, Abaddon, The Inner Eye, Gnawed Leaf, Adrenaline, Book of Revelations, Dogma (Item), Toxic Shock, Rotten Baby, Serpent's Kiss, The Pact, Ocular Rift, Pluto, Proptosis, Dark Matter, Mom's Contacts, Pupula Duplex, Box of Friends

B Tier

The Intruder, Blue Map, Genesis, Blood Bag, Eve's Mascara, Transcendence, Gello, Crooked Penny, The Soul, Scorpio, Saturnus, YO LISTEN!, Tropicamide, Duality, Lusty Blood, Paschal Candle, Lost Contact, Sulfur, Glitter Bombs, Death's Touch, Almond Milk, Treasure Map, Eden's Soul, Tarot Cloth, Cricket's Body, Divorce Papers, Immaculate Heart, Magic Skin, Brittle Bones, Camo Undies, BFFS!, Rune Bag, Worm Friend, Mysterious Liquid, The Battery, Steam Sale, Guppy's Eye, Bot Fly, Big Fan, Habit, MEAT!, Contract From Below, 9 Volt, Spider Mod, Mr. ME!, Dry Baby, Black Hole, Act of Contrition, Sumptorium, Succubus, Eye of Belial, Guppy's Collar, The Virus, My Reflection, Bozo, Mom's Key, Neptunus, Soy Milk, Brimstone, Wooden Nickel, Mega Bean, Eye of the Occult, Lachryphagy, Bob's Curse, Rosary, 4.5 Volt, The Candle, Echo Chamber, Sulfuric Acid, Card Reading, Knockout Drops, The Ludovico Technique, Angelic Prism, Blanket, Forget Me Now, Aquarius, Varicose Veins, Leech, Member Card, Cancer, Odd Mushroom (Large), Backstabber, Chocolate Milk, Pop!, Contagion, Lil Abaddon, Cain's Other Eye, Bobby-Bomb, Montezuma's Revenge, Incubus, Keeper's Box, Pyro, Capricorn, Lil Monstro, PHD, Tech.5, Money = Power, Cricket's Head, Bird's Eye, Schoolbag, Suplex!, Psy Fly, Lead Pencil, Voodoo Head, Salvation, Maw of the Void, Metal Plate, Mom's Ring, Whore of Babylon, Roid Rage, Ventricle Razor, Astral Projection, Infamy, Holy Water, Papa Fly, Dad's Key, Gimpy, The Body, Crown of Light, Dead Cat, Tooth and Nail, Mr. Mega, Alabaster Box, Damocles, Spirit of the Night, Bomber Boy, Libra, Magic Mushroom, Black Lotus, Mom's Eye, Flat Stone, Mitre, Polydactyly, My Shadow, Lucky Foot, Stem Cells, Cube of Meat, There's Options, Revelation, Pyromaniac, Pentagram, Moving Box, Guppy's Tail, Deck of Cards, Daddy Longlegs, Magic Scab, Deep Pockets, Tiny Planet, Virgo, Censer, Luna, Vanishing Twin, We Need to Go Deeper!, Lil Portal, The Wafer, 7 Seals, Fast Bombs, Stigmata, Terra, Everything Jar, Dad's Ring, Hive Mind, Jumper Cables, Empty Vessel, Stop Watch, Sticky Bombs, Options?, Dark Bum, X-Ray Vision, Mega Mush, Binge Eater, D7, Sissy Longlegs, Seraphim, Sacrificial Dagger, The Peeper, Lil Brimstone, Fanny Pack, Jaw Bone, Sacrificial Altar, Keeper's Sack, Compound Fracture, Star of Bethlehem, Smelter, The Book of Belial, Night Light, Marbles, Boom!, Purity, Torn Photo, 3 Dollar Bill, A Pony, Scapular, Box of Spiders, The Relic

C Tier

The Common Cold, Dead Tooth, Judas' Shadow, Mystery Sack, Halo of Flies, Restock, Book of the Dead, Guppy's Head, Soul Locket, Guppy's Paw, Bogo Bombs, Blue Cap, Potato Peeler, Immaculate Conception, Spirit Shackles, Synthoil, The Bible, A Bar of Soap, Guillotine, D1, Harlequin Baby, Key Piece 1, Sad Bombs, Lunch, Teleport 2.0, Odd Mushroom (Thin), Mom's Lipstick, Freezer Baby, Caffeine Pill, Crystal Ball, Divine Intervention, Pisces, Crack the Sky, Raw Liver, Golden Razor, Dog Tooth, Marrow, Eye Drops, Match Book, Flip, Lil Loki, The Polaroid, Kidney Stone, Loki's Horns, Larynx, Analog Stick, Orphan Socks, Scatter Bombs, Isaac's Tears, Sack of Pennies, Glyph of Balance, Book of Secrets, Cambion Conception, Hallowed Ground, Bloody Lust, Spear of Destiny, Brother Bobby, Skeleton Key, Stapler, Multidimensional Baby, IV Bag, Glowing Hourglass, Starter Deck, Giant Cell, Sharp Straw, Monstrance, Parasitoid, Sworn Protector, Coupon, The Mulligan, Dead Bird, Safety Pin, Plum Flute, Infestation 2, Finger!, Gemini (Item), 20/20, Cone Head, Squeezy, Consolation Prize, Lord of the Pit, Little Steven, Magic 8 Ball, Trinity Shield, Mom's Purse, Magic Fingers, Sack Head, BBF, Head of Krampus, Iron Bar, Little C.H.A.D., Uranus, My Little Unicorn, Cube Baby, Prayer Card, False PHD, The Nail, Evil Charm, Eye Sore, Mini Mush, Pandora's Box, Screw, Mars, Rainbow Baby, Stye, Experimental Treatment, Maggy's Bow, Ouija Board, Pointy Rib, Speed Ball, Purgatory, Super Bandage, Chemical Peel, Butt Bombs, Guppy's Hair Ball, Greed's Gullet, Sol, Broken Modem, Azazel's Rage, Breakfast, Guardian Angel, Polyphemus, Urn of Souls, Decap Attack, Quints, Number One, Cracked Orb, Haemolacria, Charm of the Vampire, 1up!, Blood Clot, Evil Eye, Box, Ghost Bombs, Continuum, Spiderbaby, Sagittarius, Belly Jelly, Glaucoma, Redemption, The Belt, Teleport!, How to Jump, Isaac's Tomb, Circle of Protection, Jesus Juice, Midas' Touch, Dead Onion, Jupiter, Boiled Baby, Candy Heart, ???'s Only Friend, Blood Rights, Best Bud, Charged Baby, The Compass, Magneto, Monstro's Tooth, The Book of Sin, No. 2, Doctor's Remote, Old Bandage, Rotten Tomato, Bloody Gust, Anima Sola, Zodiac, Wooden Spoon, Clear Rune, Hungry Soul, Blood Bombs, 120 Volt, Bum Friend, Robo-Baby, Stitches, Lemon Mishap, Bloodshot Eye, Best Friend, Jar of Wisps, Venus, Little Baggy, D4, Demon Baby, Telekinesis, Friend Finder, Inner Child, Plan C, A Pound of Flesh, Rocket in a Jar, Dream Catcher, The Negative, Mercurius, Steven (Item), Distant Admiration, Broken Watch, Skatole, Void, Mom's Underwear, Lil Gurdy, Satanic Bible, Lost Soul, Eraser, The Scooper, The Swarm, Free Lemonade, Ipecac, Eye of Greed, Bomb Bag, Scissors, Bird Cage, Midnight Snack, Buddy in a Box, Lil Delirium, Little Chubby, Recall, Lil Chest, Cupid's Arrow, Rotten Meat, Mystery Egg, Spider Bite, Dark Prince's Crown

D Tier

Empty Heart, D100, Pay to Play, Fate's Reward, Isaac's Heart, King Baby, The Ladder, Cursed Eye, Dinner, Key Piece 2, Dataminer, Sack of Sacks, 2Spooky, Poke Go, Slipped Rib, Notched Axe, Hot Bombs, Smart Fly, Dull Razor, Yuck Heart, Hypercoagulation, Juicy Sack, Placebo, Ankh, Abyss, Brimstone Bombs, Portable Slot, Mom's Wig, Heartbreak, Crack Jacks, Ball of Bandages, Pageant Boy, Epiphora, Belly Button, Nancy Bombs, The Boomerang, The Pinking Shears, Dr. Fetus, Vengeful Spirit, Berserk!, Monster Manual, Mega Blast, Taurus, Wavy Cap, Razor Blade, Death's List, Hushy, Mom's Box, Supper, Anemic, Robo-Baby 2.0, Sanguine Bond, Epic Fetus, Acid Baby, Lazarus' Rags, Breath of Life, Celtic Cross, Little Gish, Mom's Razor, Flush!, Strawman, Abel, Black Powder, Dad's Lost Coin, It Hurts, Anti-Gravity, The Poop, The Wiz, A Quarter, Sister Maggy, Tammy's Head, Fruity Plum, Fortune Cookie, Booster Pack (Item), Sharp Key, Bucket of Lard, Bursting Sack, Ghost Baby, Broken Glass Cannon, Headless Baby, Mom's Bottle of Pills, Shard of Glass, Spelunker Hat, Akeldama, Vasculitis, D8, Telepathy for Dummies, Mom's Bra, Unicorn Stump, Aries, Missing No., Knife Piece 2, Mr. Boom, Leo, Missing Page 2, Glass Cannon, The Hourglass, Dessert, Blood Oath, Samson's Chains, Lil Haunt, Undefined, Spin to Win, Mom's Eyeshadow, D12, Metronome, Betrayal, Tear Detonator, Vade Retro, Curse of the Tower, Friendly Ball, Red Candle, Depression, Bob's Rotten Head, The Jar, Wait What?, Esau Jr., Ball of Tar, Remote Detonator, Obsessed Fan, Hemoptysis, Marked, Battery Pack, Thunder Thighs, Friend Zone, Bone Spurs, Spider Butt, Punching Bag, Large Zit, Shade, Dead Sea Scrolls, Piggy Bank, Converter, Pause, The Gamekid, Kidney Bean, E. Coli, Lil Spewer, Forever Alone, Meat Cleaver, Milk!, <3, Tonsil, Infestation, D10, Lost Fly, GB Bug, Key Bum, Strange Attractor, Bumbo, Mine Crafter, Mom's Heels, A Snack, Leprosy, Compost, Dad's Note, Angry Fly, Mom's Bracelet, Mongo Baby, God's Flesh, Mom's Coin Purse, Brown Nugget, The Necronomicon, Mom's Pad

F Tier

Clicker, Hold, Delirious, The Bean, IBS, Sprinkler, Anarchist Cookbook, Dirty Mind, Farting Baby, Broken Shovel, Tinytoma, Mom's Shovel, Bob's Brain, Keeper's Kin, Jar of Flies, TMTRAINER, Big Chubby, Knife Piece 1, Kamikaze!, Butter Bean, Linger Bean, The Black Bean, Blood Puppy