The Best Familiars Tier List

84 Items1.1K Votes86 Voters
Updated October 19, 2025

A list of all familiar items from The Binding of Isaac: Rebirth, ranked from best to worst.

We combined votes from 86 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.


Sort by

Filter by


S
A
B
C
D
F