The Hardest Chapter 2.5 Bosses Tier List

A list of all bosses from chapter 2.5 of The Binding of Isaac: Rebirth, ranked from hardest to easiest. Chapter 2.5 includes the Mines and the Ashpit. This list is based on the latest version of The Binding of Isaac: Repentance.

8 Enemies

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8 Votes

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3  Voters

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S

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B

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F

S Tier

Tuff Twins

A Tier

Hornfel

B Tier

Reap Creep, Singe

C Tier

The Pile, Great Gideon

D Tier

The Shell

F Tier

Clutch

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