The Hardest Binding of Isaac Bosses
A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest. We combined votes from 4 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.
Vote Now27 Enemies
38 Votes
4 Voters
My Votes
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Rating
1.The Visage
1100Rating0
Spread1.Tuff Twins
1100Rating0
Spread3.Mega Satan
395Rating1.5
Spread4.Ultra Greedier
295Rating4.8
Spread5.Delirium
192Rating0
Spread6.Hornfel
186Rating0
Spread7.The Heretic
175Rating0
Spread8.Mother
271Rating0
Spread8.Reap Creep
171Rating0
Spread10.Hush
164Rating0
Spread11.Ultra Greed
259Rating20.4
Spread12.Dogma
157Rating0
Spread12.Singe
157Rating0
Spread14.??? (Boss)
150Rating0
Spread14.The Siren
150Rating0
Spread16.Satan
143Rating0
Spread16.The Pile
143Rating0
Spread18.Great Gideon
129Rating0
Spread19.Mom's Heart
227Rating10.9
Spread20.The Horny Boys
125Rating0
Spread21.The Lamb
322Rating6
Spread22.Mom
121Rating0
Spread23.The Beast
220Rating19.2
Spread24.Isaac (Boss)
219Rating9.4
Spread25.The Shell
114Rating0
Spread26.It Lives
25Rating2.3
Spread27.Clutch
10Rating0
Spread
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