The Hardest Binding of Isaac Bosses

A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 8 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

102 Enemies

266 Votes

8 Voters

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1.Ultra War
1.Ultra War
Boss
Home
2
100
Rating
2.4
Spread
2
100
Rating
2.4
Spread

2.Ultra Pestilence
2.Ultra Pestilence
Boss
Home
2
98
Rating
2.9
Spread
2
98
Rating
2.9
Spread

3.The Visage
3.The Visage
Chapter 3.5
Boss
3
98
Rating
2.9
Spread
3
98
Rating
2.9
Spread

4.Mega Satan
4.Mega Satan
Chapter 6
Final Boss
Boss
5
98
Rating
1.4
Spread
5
98
Rating
1.4
Spread

5.Min-Min
5.Min-Min
Chapter 1.5
Boss
2
94
Rating
4.6
Spread
2
94
Rating
4.6
Spread

6.Ultra Greedier
6.Ultra Greedier
Final Boss
Greed Mode
Boss
4
94
Rating
6.2
Spread
4
94
Rating
6.2
Spread

7.Bumbino
7.Bumbino
Chapter 2
Boss
2
89
Rating
2.5
Spread
2
89
Rating
2.5
Spread

8.Daddy Long Legs
8.Daddy Long Legs
Chapter 4
Boss
2
85
Rating
6.8
Spread
2
85
Rating
6.8
Spread

8.Scolex
8.Scolex
Chapter 4
Boss
2
85
Rating
6.8
Spread
2
85
Rating
6.8
Spread

8.Wormwood
8.Wormwood
Chapter 1.5
Boss
2
85
Rating
6.8
Spread
2
85
Rating
6.8
Spread

8.The Cage
8.The Cage
Chapter 3
Boss
2
85
Rating
6.8
Spread
2
85
Rating
6.8
Spread

12.Rag Man
12.Rag Man
Chapter 1
Boss
3
83
Rating
10.2
Spread
3
83
Rating
10.2
Spread

13.The Heretic
13.The Heretic
Chapter 3.5
Boss
3
82
Rating
3.5
Spread
3
82
Rating
3.5
Spread

14.Delirium
14.Delirium
Final Boss
Boss
The Void
4
80
Rating
7.8
Spread
4
80
Rating
7.8
Spread

15.Ultra Greed
15.Ultra Greed
Final Boss
Greed Mode
Boss
4
80
Rating
5.2
Spread
4
80
Rating
5.2
Spread

16.The Frail
16.The Frail
Chapter 2
Boss
2
79
Rating
21.8
Spread
2
79
Rating
21.8
Spread

17.Tuff Twins
17.Tuff Twins
Chapter 2.5
Boss
3
74
Rating
12.7
Spread
3
74
Rating
12.7
Spread

18.Mother
18.Mother
Final Boss
Boss
Corpse
4
72
Rating
7.2
Spread
4
72
Rating
7.2
Spread

19.Steven
19.Steven
Chapter 1
Boss
3
72
Rating
12.7
Spread
3
72
Rating
12.7
Spread

20.Gurglings
20.Gurglings
Chapter 1
Boss
3
71
Rating
14.9
Spread
3
71
Rating
14.9
Spread

21.Hush
21.Hush
Final Boss
Boss
???
4
71
Rating
7.2
Spread
4
71
Rating
7.2
Spread

22.The Pile
22.The Pile
Chapter 2.5
Boss
3
70
Rating
10.3
Spread
3
70
Rating
10.3
Spread

23.Chimera
23.Chimera
Boss
Corpse
2
70
Rating
15.9
Spread
2
70
Rating
15.9
Spread

24.Blighted Ovum
24.Blighted Ovum
Chapter 1
Boss
3
69
Rating
11.6
Spread
3
69
Rating
11.6
Spread

25.Dogma
25.Dogma
Final Boss
Boss
Home
4
68
Rating
6.9
Spread
4
68
Rating
6.9
Spread

26.Famine
26.Famine
Chapter 1
Boss
3
66
Rating
10.4
Spread
3
66
Rating
10.4
Spread

27.Teratoma
27.Teratoma
Chapter 4
Boss
2
64
Rating
9.9
Spread
2
64
Rating
9.9
Spread

27.The Rainmaker
27.The Rainmaker
Chapter 1.5
Boss
2
64
Rating
9.9
Spread
2
64
Rating
9.9
Spread

27.The Fallen
27.The Fallen
Boss
2
64
Rating
9.9
Spread
2
64
Rating
9.9
Spread

27.The Adversary
27.The Adversary
Chapter 3
Boss
2
64
Rating
9.9
Spread
2
64
Rating
9.9
Spread

31.Colostomia
31.Colostomia
Chapter 1.5
Boss
2
64
Rating
11.2
Spread
2
64
Rating
11.2
Spread

32.Turdlings
32.Turdlings
Chapter 1
Boss
3
61
Rating
9.2
Spread
3
61
Rating
9.2
Spread

33.Reap Creep
33.Reap Creep
Chapter 2.5
Boss
3
60
Rating
7.7
Spread
3
60
Rating
7.7
Spread

34.Larry Jr.
34.Larry Jr.
Chapter 1
Boss
3
59
Rating
2.3
Spread
3
59
Rating
2.3
Spread

34.Widow
34.Widow
Chapter 1
Boss
3
59
Rating
2.3
Spread
3
59
Rating
2.3
Spread

36.Ultra Death
36.Ultra Death
Boss
Home
2
58
Rating
4.2
Spread
2
58
Rating
4.2
Spread

36.Triachnid
36.Triachnid
Chapter 4
Boss
2
58
Rating
4.2
Spread
2
58
Rating
4.2
Spread

36.Gurdy Jr.
36.Gurdy Jr.
Chapter 2
Boss
2
58
Rating
4.2
Spread
2
58
Rating
4.2
Spread

36.Mask of Infamy
36.Mask of Infamy
Chapter 3
Boss
2
58
Rating
4.2
Spread
2
58
Rating
4.2
Spread

36.Dark One
36.Dark One
Chapter 2
Boss
2
58
Rating
4.2
Spread
2
58
Rating
4.2
Spread

41.Clutch
41.Clutch
Chapter 2.5
Boss
3
58
Rating
20.4
Spread
3
58
Rating
20.4
Spread

42.Gemini
42.Gemini
Chapter 1
Boss
3
53
Rating
7
Spread
3
53
Rating
7
Spread

43.Satan
43.Satan
Chapter 5
Final Boss
Boss
4
52
Rating
4.1
Spread
4
52
Rating
4.1
Spread

44.Little Horn
44.Little Horn
Chapter 1
Boss
3
51
Rating
7.3
Spread
3
51
Rating
7.3
Spread

45.Mega Fatty
45.Mega Fatty
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Loki
45.Loki
Chapter 3
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.The Husk
45.The Husk
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Death (Boss)
45.Death (Boss)
Chapter 4
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Carrion Queen
45.Carrion Queen
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.The Gate
45.The Gate
Chapter 3
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Chub
45.Chub
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Turdlet
45.Turdlet
Chapter 1.5
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Pestilence
45.Pestilence
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.The Matriarch
45.The Matriarch
Chapter 4
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Mama Gurdy
45.Mama Gurdy
Chapter 4
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Fistula
45.Fistula
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Gish
45.Gish
Chapter 3
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Blastocyst
45.Blastocyst
Chapter 4
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Monstro II
45.Monstro II
Chapter 3
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Peep
45.Peep
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Ultra Famine
45.Ultra Famine
Boss
Home
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.War
45.War
Chapter 3
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.The Wretched
45.The Wretched
Chapter 2
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

45.Mr. Fred
45.Mr. Fred
Chapter 4
Boss
2
48
Rating
13.4
Spread
2
48
Rating
13.4
Spread

65.Hornfel
65.Hornfel
Chapter 2.5
Boss
3
48
Rating
17.1
Spread
3
48
Rating
17.1
Spread

66.Dingle
66.Dingle
Chapter 1
Boss
3
48
Rating
9.7
Spread
3
48
Rating
9.7
Spread

67.The Duke of Flies
67.The Duke of Flies
Chapter 1
Boss
3
44
Rating
8.8
Spread
3
44
Rating
8.8
Spread

67.The Haunt
67.The Haunt
Chapter 1
Boss
3
44
Rating
8.8
Spread
3
44
Rating
8.8
Spread

67.Monstro
67.Monstro
Chapter 1
Boss
3
44
Rating
8.8
Spread
3
44
Rating
8.8
Spread

70.It Lives
70.It Lives
Final Boss
Chapter 4
Boss
4
44
Rating
10.3
Spread
4
44
Rating
10.3
Spread

71.Mom
71.Mom
Final Boss
Chapter 3
Boss
4
44
Rating
5.9
Spread
4
44
Rating
5.9
Spread

72.Singe
72.Singe
Chapter 2.5
Boss
3
43
Rating
15.7
Spread
3
43
Rating
15.7
Spread

73.Isaac (Boss)
73.Isaac (Boss)
Chapter 5
Final Boss
Boss
4
37
Rating
5.1
Spread
4
37
Rating
5.1
Spread

74.The Lamb
74.The Lamb
Chapter 6
Final Boss
Boss
5
36
Rating
10.5
Spread
5
36
Rating
10.5
Spread

75.??? (Boss)
75.??? (Boss)
Chapter 6
Final Boss
Boss
4
35
Rating
6.7
Spread
4
35
Rating
6.7
Spread

76.Baby Plum
76.Baby Plum
Chapter 1
Boss
3
34
Rating
15.5
Spread
3
34
Rating
15.5
Spread

77.Mom's Heart
77.Mom's Heart
Final Boss
Chapter 3.5
Boss
5
32
Rating
4.8
Spread
5
32
Rating
4.8
Spread

78.The Horny Boys
78.The Horny Boys
Chapter 3.5
Boss
3
30
Rating
14.9
Spread
3
30
Rating
14.9
Spread

79.Rotgut
79.Rotgut
Boss
Corpse
2
27
Rating
27.4
Spread
2
27
Rating
27.4
Spread

79.Rag Mega
79.Rag Mega
Chapter 2
Boss
2
27
Rating
27.4
Spread
2
27
Rating
27.4
Spread

81.The Siren
81.The Siren
Chapter 3.5
Boss
3
25
Rating
10.3
Spread
3
25
Rating
10.3
Spread

82.The Beast
82.The Beast
Final Boss
Boss
Home
4
25
Rating
8
Spread
4
25
Rating
8
Spread

83.Great Gideon
83.Great Gideon
Chapter 2.5
Boss
3
23
Rating
9
Spread
3
23
Rating
9
Spread

84.The Bloat
84.The Bloat
Chapter 3
Boss
2
23
Rating
27.1
Spread
2
23
Rating
27.1
Spread

85.Pin
85.Pin
Chapter 1
Boss
3
22
Rating
4
Spread
3
22
Rating
4
Spread

86.The Stain
86.The Stain
Chapter 2
Boss
2
17
Rating
19.9
Spread
2
17
Rating
19.9
Spread

86.Lokii
86.Lokii
Chapter 4
Boss
2
17
Rating
19.9
Spread
2
17
Rating
19.9
Spread

86.Mega Maw
86.Mega Maw
Chapter 2
Boss
2
17
Rating
19.9
Spread
2
17
Rating
19.9
Spread

86.Big Horn
86.Big Horn
Chapter 2
Boss
2
17
Rating
19.9
Spread
2
17
Rating
19.9
Spread

90.The Shell
90.The Shell
Chapter 2.5
Boss
3
8
Rating
2.6
Spread
3
8
Rating
2.6
Spread

91.Dangle
91.Dangle
Chapter 1
Boss
3
3
Rating
1.1
Spread
3
3
Rating
1.1
Spread

92.The Forsaken
92.The Forsaken
Chapter 2
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.C.H.A.D.
92.C.H.A.D.
Chapter 2
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.Brownie
92.Brownie
Chapter 3
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.The Hollow
92.The Hollow
Chapter 2
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.Clog
92.Clog
Chapter 1.5
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.Conquest
92.Conquest
Chapter 4
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.Sisters Vis
92.Sisters Vis
Chapter 3
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.The Headless Horseman
92.The Headless Horseman
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

92.Gurdy
92.Gurdy
Chapter 2
Boss
2
2
Rating
0.6
Spread
2
2
Rating
0.6
Spread

101.Polycephalus
101.Polycephalus
Chapter 2
Boss
2
0
Rating
0
Spread
2
0
Rating
0
Spread

101.Lil Blub
101.Lil Blub
Chapter 1.5
Boss
2
0
Rating
0
Spread
2
0
Rating
0
Spread