The Hardest Binding of Isaac Bosses - Hardest Tier List

S

A

B

C

D

F

S Tier

Mega Satan

A Tier

The Visage, Delirium, Ultra Greedier, Hush, Ultra Greed, The Scourge, Mother, Bumbino, Chimera, The Heretic, Dogma, Min-Min, The Adversary

B Tier

Wormwood, Ultra War, Clutch, Ultra Pestilence, The Lamb, The Pile, Daddy Long Legs, Ultra Death, Rag Mega, Mask of Infamy, The Bloat, Satan, The Rainmaker, The Stain, Singe, Gurdy Jr., Reap Creep, Colostomia, Mama Gurdy, Mom, Triachnid, ??? (Boss), Rag Man, The Cage, It Lives, Dark One

C Tier

Carrion Queen, Peep, Scolex, Hornfel, Rotgut, Pestilence, Sisters Vis, Monstro II, Blighted Ovum, Ultra Famine, Tuff Twins, Steven, Mom's Heart, The Beast, Teratoma, The Haunt, Turdlet, War, The Horny Boys, Great Gideon, Widow, Famine, Isaac (Boss), The Frail, Turdlings, The Gate, Death (Boss), The Wretched, Gemini, Fistula, Mega Maw, The Siren, Little Horn

D Tier

Dingle, The Fallen, Mega Fatty, Baby Plum, C.H.A.D., Conquest, Mr. Fred, Chub, The Matriarch, Larry Jr., Gish, Dangle, Clog, The Husk, Loki, Gurglings, The Forsaken, The Shell, Big Horn, Lokii, Blastocyst, Brownie, The Headless Horseman, Monstro, Polycephalus, Pin, Lil Blub

F Tier

The Duke of Flies, The Hollow, Gurdy