The Hardest Chapter 2.5 Bosses
A list of all bosses from chapter 2.5 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.
Chapter 2.5 includes the Mines and the Ashpit.
This list is based on the latest version of The Binding of Isaac: Repentance.
Vote Now8 Enemies
16 Votes
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1.Tuff Twins
2100Rating15.5
Spread2.The Pile
284Rating26.5
Spread3.Reap Creep
281Rating2.2
Spread4.Clutch
256Rating46.4
Spread5.Hornfel
247Rating39.8
Spread6.Singe
228Rating26.5
Spread7.Great Gideon
29Rating13.3
Spread8.The Shell
20Rating6.6
Spread
