The Hardest Chapter 2.5 Bosses - Hardest Tier List

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48 Votes

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Updated January 26, 2026

A list of all bosses from chapter 2.5 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 2.5 includes the Mines and the Ashpit.

This list is based on the latest version of The Binding of Isaac: Repentance.

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