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The Hardest Chapter 3 Bosses

A list of all bosses from chapter 3 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 3 includes the Depths, Necropolis, and the Dank Depths.

This list is based on the latest version of The Binding of Isaac: Repentance.

Rankings updated August 27, 2025.
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12 Enemies

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All 12 Chapter 3 Bosses Ranked, Hardest to Easiest | The Binding of Isaac | Unduel