The Hardest Chapter 3 Bosses - Hardest Tier List

12 Enemies

48 Votes

4 Voters

Updated August 27, 2025

A list of all bosses from chapter 3 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 3 includes the Depths, Necropolis, and the Dank Depths.

This list is based on the latest version of The Binding of Isaac: Repentance.

Sort by

Filter by

S

A

B

C

D

F

Chapter 3 Boss Tier List | The Binding of Isaac | Unduel