The Hardest Chapter 4 Bosses

A list of all bosses from chapter 4 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 4 includes the Womb, Utero, and the Scarred Womb.

This list is based on the latest version of The Binding of Isaac: Repentance.

Rankings updated August 27, 2025.

12 Enemies

48 Votes

4 Voters

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All 12 Chapter 4 Bosses Ranked, Hardest to Easiest | The Binding of Isaac | Unduel