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The Hardest Final Bosses

A list of all final bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 7 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

Rankings updated August 27, 2025.
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15 Enemies

92  Votes

7  Voters

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The Best Passive Items-1The Best Passive Items-2The Best Passive Items-3
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All 15 Final Bosses Ranked, Hardest to Easiest | The Binding of Isaac | Unduel