The Hardest Final Bosses - Hardest Tier List

15 Enemies

110 Votes

9 Voters

Updated January 26, 2026

A list of all final bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 9 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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