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The Hardest Final Bosses

A list of all final bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 6 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

Rankings updated July 16, 2025.
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15 Enemies

77  Votes

6  Voters

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All 15 Final Bosses Ranked, Hardest to Easiest | The Binding of Isaac | Unduel