The Hardest Chapter 2 Bosses - Hardest Tier List

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84 Votes

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Updated August 27, 2025

A list of all bosses from chapter 2 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 2 includes the Caves, the Catacombs, and the Flooded Caves.

This list is based on the latest version of The Binding of Isaac: Repentance.

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