The Hardest Chapter 2 Bosses Tier List
A list of all bosses from chapter 2 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.
Chapter 2 includes the Caves, the Catacombs, and the Flooded Caves.
This list is based on the latest version of The Binding of Isaac: Repentance.
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Rating
S
A
B
C
D
F
S Tier
Bumbino
A Tier
Gurdy Jr., Dark One, Carrion Queen, The Wretched, Mega Fatty
B Tier
The Frail, Peep, Pestilence, Chub, The Stain, Fistula, The Husk
C Tier
Big Horn, Rag Mega, Mega Maw
D Tier
The Forsaken, C.H.A.D.
F Tier
The Hollow, Gurdy, Polycephalus
