The Hardest Chapter 2 Bosses Tier List

A list of all bosses from chapter 2 of The Binding of Isaac: Rebirth, ranked from hardest to easiest.

Chapter 2 includes the Caves, the Catacombs, and the Flooded Caves.

This list is based on the latest version of The Binding of Isaac: Repentance.

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21 Enemies

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S
Bumbino
A
Gurdy Jr.
Dark One
Carrion Queen
The Wretched
Mega Fatty
B
The Frail
Peep
Pestilence
Chub
The Stain
Fistula
The Husk
C
Big Horn
Rag Mega
Mega Maw
D
The Forsaken
C.H.A.D.
F
The Hollow
Gurdy
Polycephalus

S Tier

Bumbino

A Tier

Gurdy Jr., Dark One, Carrion Queen, The Wretched, Mega Fatty

B Tier

The Frail, Peep, Pestilence, Chub, The Stain, Fistula, The Husk

C Tier

Big Horn, Rag Mega, Mega Maw

D Tier

The Forsaken, C.H.A.D.

F Tier

The Hollow, Gurdy, Polycephalus