The Hardest Binding of Isaac Bosses - Hardest Rankings

103 Enemies

592 Votes

12 Voters

Updated January 26, 2026

A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest.

We combined votes from 12 players to create this list.

Based on the latest version of The Binding of Isaac: Repentance.

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1.Mega Satan
1.Mega Satan
Chapter 6
Final Boss
Boss
8
100
Rating
83
CONS
8
100
Rating
83
CONS

2.The Visage
2.The Visage
Chapter 3.5
Boss
6
94
Rating
83
CONS
6
94
Rating
83
CONS

3.Delirium
3.Delirium
Final Boss
Boss
The Void
7
93
Rating
74
CONS
7
93
Rating
74
CONS

4.Ultra Greedier
4.Ultra Greedier
Final Boss
Greed Mode
Boss
7
89
Rating
62
CONS
7
89
Rating
62
CONS

5.Hush
5.Hush
Final Boss
Boss
???
7
88
Rating
76
CONS
7
88
Rating
76
CONS

6.Ultra Greed
6.Ultra Greed
Final Boss
Greed Mode
Boss
7
88
Rating
69
CONS
7
88
Rating
69
CONS

7.The Scourge
7.The Scourge
Boss
Corpse
4
87
Rating
80
CONS
4
87
Rating
80
CONS

8.Mother
8.Mother
Final Boss
Boss
Corpse
7
87
Rating
71
CONS
7
87
Rating
71
CONS

9.Bumbino
9.Bumbino
Chapter 2
Boss
5
82
Rating
73
CONS
5
82
Rating
73
CONS

10.Chimera
10.Chimera
Boss
Corpse
5
81
Rating
66
CONS
5
81
Rating
66
CONS

11.The Heretic
11.The Heretic
Chapter 3.5
Boss
6
81
Rating
75
CONS
6
81
Rating
75
CONS

12.Dogma
12.Dogma
Final Boss
Boss
Home
8
80
Rating
64
CONS
8
80
Rating
64
CONS

13.Min-Min
13.Min-Min
Chapter 1.5
Boss
5
75
Rating
59
CONS
5
75
Rating
59
CONS

14.The Adversary
14.The Adversary
Chapter 3
Boss
5
73
Rating
60
CONS
5
73
Rating
60
CONS

15.Wormwood
15.Wormwood
Chapter 1.5
Boss
5
70
Rating
62
CONS
5
70
Rating
62
CONS

16.Ultra War
16.Ultra War
Boss
Home
5
69
Rating
50
CONS
5
69
Rating
50
CONS

17.Clutch
17.Clutch
Chapter 2.5
Boss
6
68
Rating
68
CONS
6
68
Rating
68
CONS

18.Ultra Pestilence
18.Ultra Pestilence
Boss
Home
6
68
Rating
49
CONS
6
68
Rating
49
CONS

19.The Lamb
19.The Lamb
Chapter 6
Final Boss
Boss
9
67
Rating
69
CONS
9
67
Rating
69
CONS

20.The Pile
20.The Pile
Chapter 2.5
Boss
6
65
Rating
58
CONS
6
65
Rating
58
CONS

21.Daddy Long Legs
21.Daddy Long Legs
Chapter 4
Boss
5
64
Rating
55
CONS
5
64
Rating
55
CONS

22.Ultra Death
22.Ultra Death
Boss
Home
5
62
Rating
45
CONS
5
62
Rating
45
CONS

23.Rag Mega
23.Rag Mega
Chapter 2
Boss
5
61
Rating
46
CONS
5
61
Rating
46
CONS

24.Mask of Infamy
24.Mask of Infamy
Chapter 3
Boss
5
60
Rating
52
CONS
5
60
Rating
52
CONS

25.The Bloat
25.The Bloat
Chapter 3
Boss
5
59
Rating
42
CONS
5
59
Rating
42
CONS

26.Satan
26.Satan
Chapter 5
Final Boss
Boss
7
58
Rating
52
CONS
7
58
Rating
52
CONS

27.The Rainmaker
27.The Rainmaker
Chapter 1.5
Boss
6
57
Rating
38
CONS
6
57
Rating
38
CONS

28.The Stain
28.The Stain
Chapter 2
Boss
5
57
Rating
45
CONS
5
57
Rating
45
CONS

29.Singe
29.Singe
Chapter 2.5
Boss
6
54
Rating
45
CONS
6
54
Rating
45
CONS

30.Gurdy Jr.
30.Gurdy Jr.
Chapter 2
Boss
5
54
Rating
38
CONS
5
54
Rating
38
CONS

31.Reap Creep
31.Reap Creep
Chapter 2.5
Boss
6
54
Rating
48
CONS
6
54
Rating
48
CONS

32.Colostomia
32.Colostomia
Chapter 1.5
Boss
5
53
Rating
45
CONS
5
53
Rating
45
CONS

33.Mama Gurdy
33.Mama Gurdy
Chapter 4
Boss
5
53
Rating
45
CONS
5
53
Rating
45
CONS

34.Mom
34.Mom
Final Boss
Chapter 3
Boss
7
53
Rating
48
CONS
7
53
Rating
48
CONS

35.Triachnid
35.Triachnid
Chapter 4
Boss
6
52
Rating
39
CONS
6
52
Rating
39
CONS

36.??? (Boss)
36.??? (Boss)
Chapter 6
Final Boss
Boss
7
51
Rating
44
CONS
7
51
Rating
44
CONS

37.Rag Man
37.Rag Man
Chapter 1
Boss
6
50
Rating
38
CONS
6
50
Rating
38
CONS

38.The Cage
38.The Cage
Chapter 3
Boss
5
49
Rating
39
CONS
5
49
Rating
39
CONS

39.It Lives
39.It Lives
Final Boss
Chapter 4
Boss
7
49
Rating
47
CONS
7
49
Rating
47
CONS

40.Dark One
40.Dark One
Chapter 2
Boss
6
49
Rating
38
CONS
6
49
Rating
38
CONS

41.Carrion Queen
41.Carrion Queen
Chapter 2
Boss
5
47
Rating
43
CONS
5
47
Rating
43
CONS

42.Peep
42.Peep
Chapter 2
Boss
5
45
Rating
39
CONS
5
45
Rating
39
CONS

43.Scolex
43.Scolex
Chapter 4
Boss
5
44
Rating
36
CONS
5
44
Rating
36
CONS

44.Hornfel
44.Hornfel
Chapter 2.5
Boss
6
44
Rating
44
CONS
6
44
Rating
44
CONS

45.Rotgut
45.Rotgut
Boss
Corpse
5
43
Rating
28
CONS
5
43
Rating
28
CONS

46.Pestilence
46.Pestilence
Chapter 2
Boss
5
42
Rating
42
CONS
5
42
Rating
42
CONS

47.Sisters Vis
47.Sisters Vis
Chapter 3
Boss
5
41
Rating
36
CONS
5
41
Rating
36
CONS

48.Monstro II
48.Monstro II
Chapter 3
Boss
5
41
Rating
39
CONS
5
41
Rating
39
CONS

49.Blighted Ovum
49.Blighted Ovum
Chapter 1
Boss
7
41
Rating
37
CONS
7
41
Rating
37
CONS

50.Ultra Famine
50.Ultra Famine
Boss
Home
5
41
Rating
36
CONS
5
41
Rating
36
CONS

51.Tuff Twins
51.Tuff Twins
Chapter 2.5
Boss
7
40
Rating
40
CONS
7
40
Rating
40
CONS

52.Steven
52.Steven
Chapter 1
Boss
7
40
Rating
36
CONS
7
40
Rating
36
CONS

53.Mom's Heart
53.Mom's Heart
Final Boss
Chapter 3.5
Boss
9
39
Rating
45
CONS
9
39
Rating
45
CONS

54.The Beast
54.The Beast
Final Boss
Boss
Home
7
38
Rating
54
CONS
7
38
Rating
54
CONS

55.Teratoma
55.Teratoma
Chapter 4
Boss
5
37
Rating
27
CONS
5
37
Rating
27
CONS

56.The Haunt
56.The Haunt
Chapter 1
Boss
6
37
Rating
42
CONS
6
37
Rating
42
CONS

57.Turdlet
57.Turdlet
Chapter 1.5
Boss
5
36
Rating
39
CONS
5
36
Rating
39
CONS

58.War
58.War
Chapter 3
Boss
5
36
Rating
29
CONS
5
36
Rating
29
CONS

59.The Horny Boys
59.The Horny Boys
Chapter 3.5
Boss
6
36
Rating
46
CONS
6
36
Rating
46
CONS

60.Great Gideon
60.Great Gideon
Chapter 2.5
Boss
6
35
Rating
48
CONS
6
35
Rating
48
CONS

61.Widow
61.Widow
Chapter 1
Boss
6
34
Rating
42
CONS
6
34
Rating
42
CONS

62.Famine
62.Famine
Chapter 1
Boss
6
34
Rating
43
CONS
6
34
Rating
43
CONS

63.Isaac (Boss)
63.Isaac (Boss)
Chapter 5
Final Boss
Boss
7
34
Rating
40
CONS
7
34
Rating
40
CONS

64.The Frail
64.The Frail
Chapter 2
Boss
5
34
Rating
29
CONS
5
34
Rating
29
CONS

65.Turdlings
65.Turdlings
Chapter 1
Boss
6
32
Rating
44
CONS
6
32
Rating
44
CONS

66.The Gate
66.The Gate
Chapter 3
Boss
5
31
Rating
35
CONS
5
31
Rating
35
CONS

67.Death (Boss)
67.Death (Boss)
Chapter 4
Boss
5
31
Rating
42
CONS
5
31
Rating
42
CONS

68.The Wretched
68.The Wretched
Chapter 2
Boss
5
31
Rating
42
CONS
5
31
Rating
42
CONS

69.Gemini
69.Gemini
Chapter 1
Boss
6
30
Rating
39
CONS
6
30
Rating
39
CONS

70.Fistula
70.Fistula
Chapter 2
Boss
5
30
Rating
34
CONS
5
30
Rating
34
CONS

71.Mega Maw
71.Mega Maw
Chapter 2
Boss
6
30
Rating
29
CONS
6
30
Rating
29
CONS

72.The Siren
72.The Siren
Chapter 3.5
Boss
6
29
Rating
47
CONS
6
29
Rating
47
CONS

73.Little Horn
73.Little Horn
Chapter 1
Boss
6
28
Rating
43
CONS
6
28
Rating
43
CONS

74.Dingle
74.Dingle
Chapter 1
Boss
7
27
Rating
32
CONS
7
27
Rating
32
CONS

75.The Fallen
75.The Fallen
Boss
5
27
Rating
34
CONS
5
27
Rating
34
CONS

76.Mega Fatty
76.Mega Fatty
Chapter 2
Boss
6
26
Rating
32
CONS
6
26
Rating
32
CONS

77.Baby Plum
77.Baby Plum
Chapter 1
Boss
6
26
Rating
48
CONS
6
26
Rating
48
CONS

78.C.H.A.D.
78.C.H.A.D.
Chapter 2
Boss
5
25
Rating
35
CONS
5
25
Rating
35
CONS

79.Conquest
79.Conquest
Chapter 4
Boss
5
24
Rating
41
CONS
5
24
Rating
41
CONS

80.Mr. Fred
80.Mr. Fred
Chapter 4
Boss
6
23
Rating
34
CONS
6
23
Rating
34
CONS

81.Chub
81.Chub
Chapter 2
Boss
5
23
Rating
42
CONS
5
23
Rating
42
CONS

82.The Matriarch
82.The Matriarch
Chapter 4
Boss
5
22
Rating
40
CONS
5
22
Rating
40
CONS

83.Larry Jr.
83.Larry Jr.
Chapter 1
Boss
6
21
Rating
44
CONS
6
21
Rating
44
CONS

84.Gish
84.Gish
Chapter 3
Boss
5
21
Rating
41
CONS
5
21
Rating
41
CONS

85.Dangle
85.Dangle
Chapter 1
Boss
6
21
Rating
42
CONS
6
21
Rating
42
CONS

86.Clog
86.Clog
Chapter 1.5
Boss
5
20
Rating
41
CONS
5
20
Rating
41
CONS

87.The Husk
87.The Husk
Chapter 2
Boss
5
20
Rating
40
CONS
5
20
Rating
40
CONS

88.Loki
88.Loki
Chapter 3
Boss
5
20
Rating
40
CONS
5
20
Rating
40
CONS

89.Gurglings
89.Gurglings
Chapter 1
Boss
6
18
Rating
41
CONS
6
18
Rating
41
CONS

90.The Forsaken
90.The Forsaken
Chapter 2
Boss
5
17
Rating
46
CONS
5
17
Rating
46
CONS

91.The Shell
91.The Shell
Chapter 2.5
Boss
6
17
Rating
51
CONS
6
17
Rating
51
CONS

92.Big Horn
92.Big Horn
Chapter 2
Boss
5
17
Rating
46
CONS
5
17
Rating
46
CONS

93.Lokii
93.Lokii
Chapter 4
Boss
6
17
Rating
41
CONS
6
17
Rating
41
CONS

94.Blastocyst
94.Blastocyst
Chapter 4
Boss
5
15
Rating
47
CONS
5
15
Rating
47
CONS

95.Brownie
95.Brownie
Chapter 3
Boss
5
15
Rating
45
CONS
5
15
Rating
45
CONS

96.The Headless Horseman
96.The Headless Horseman
Boss
5
15
Rating
49
CONS
5
15
Rating
49
CONS

97.Monstro
97.Monstro
Chapter 1
Boss
6
11
Rating
49
CONS
6
11
Rating
49
CONS

98.Polycephalus
98.Polycephalus
Chapter 2
Boss
5
9
Rating
53
CONS
5
9
Rating
53
CONS

99.Pin
99.Pin
Chapter 1
Boss
7
9
Rating
50
CONS
7
9
Rating
50
CONS

100.Lil Blub
100.Lil Blub
Chapter 1.5
Boss
5
7
Rating
57
CONS
5
7
Rating
57
CONS

101.The Duke of Flies
101.The Duke of Flies
Chapter 1
Boss
6
3
Rating
58
CONS
6
3
Rating
58
CONS

102.The Hollow
102.The Hollow
Chapter 2
Boss
5
2
Rating
64
CONS
5
2
Rating
64
CONS

103.Gurdy
103.Gurdy
Chapter 2
Boss
5
0
Rating
67
CONS
5
0
Rating
67
CONS