The Hardest Binding of Isaac Bosses

A list of all bosses from The Binding of Isaac: Rebirth, ranked from hardest to easiest. We combined votes from 6 players to create this list. Based on the latest version of The Binding of Isaac: Repentance.

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27 Enemies

72 Votes

6 Voters

Tier List

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1.The Visage
1.The Visage
Chapter 3.5
Boss
2
100
Rating
0.6
Spread
2
100
Rating
0.6
Spread

2.Mega Satan
2.Mega Satan
Chapter 6
Final Boss
Boss
4
98
Rating
0.7
Spread
4
98
Rating
0.7
Spread

3.Ultra Greedier
3.Ultra Greedier
Final Boss
Greed Mode
Boss
3
98
Rating
0.9
Spread
3
98
Rating
0.9
Spread

4.Delirium
4.Delirium
Final Boss
Boss
The Void
3
95
Rating
8.1
Spread
3
95
Rating
8.1
Spread

5.The Pile
5.The Pile
Chapter 2.5
Boss
2
94
Rating
10.1
Spread
2
94
Rating
10.1
Spread

6.Mother
6.Mother
Final Boss
Boss
Corpse
3
93
Rating
8.8
Spread
3
93
Rating
8.8
Spread

7.Hush
7.Hush
Final Boss
Boss
???
3
91
Rating
8.8
Spread
3
91
Rating
8.8
Spread

8.The Heretic
8.The Heretic
Chapter 3.5
Boss
2
90
Rating
2
Spread
2
90
Rating
2
Spread

9.Clutch
9.Clutch
Chapter 2.5
Boss
2
90
Rating
18.5
Spread
2
90
Rating
18.5
Spread

10.Dogma
10.Dogma
Final Boss
Boss
Home
3
81
Rating
7.4
Spread
3
81
Rating
7.4
Spread

11.The Lamb
11.The Lamb
Chapter 6
Final Boss
Boss
4
79
Rating
12.1
Spread
4
79
Rating
12.1
Spread

12.It Lives
12.It Lives
Final Boss
Chapter 4
Boss
3
75
Rating
12.3
Spread
3
75
Rating
12.3
Spread

13.Ultra Greed
13.Ultra Greed
Final Boss
Greed Mode
Boss
3
62
Rating
6
Spread
3
62
Rating
6
Spread

14.Tuff Twins
14.Tuff Twins
Chapter 2.5
Boss
2
58
Rating
9.1
Spread
2
58
Rating
9.1
Spread

15.Reap Creep
15.Reap Creep
Chapter 2.5
Boss
2
56
Rating
3.5
Spread
2
56
Rating
3.5
Spread

16.Satan
16.Satan
Chapter 5
Final Boss
Boss
3
51
Rating
2.3
Spread
3
51
Rating
2.3
Spread

17.Isaac (Boss)
17.Isaac (Boss)
Chapter 5
Final Boss
Boss
3
50
Rating
3.8
Spread
3
50
Rating
3.8
Spread

18.Mom
18.Mom
Final Boss
Chapter 3
Boss
3
49
Rating
4.7
Spread
3
49
Rating
4.7
Spread

19.Mom's Heart
19.Mom's Heart
Final Boss
Chapter 3.5
Boss
4
48
Rating
3.6
Spread
4
48
Rating
3.6
Spread

20.The Beast
20.The Beast
Final Boss
Boss
Home
3
42
Rating
9.3
Spread
3
42
Rating
9.3
Spread

21.??? (Boss)
21.??? (Boss)
Chapter 6
Final Boss
Boss
3
9
Rating
7.9
Spread
3
9
Rating
7.9
Spread

22.Hornfel
22.Hornfel
Chapter 2.5
Boss
2
6
Rating
16.4
Spread
2
6
Rating
16.4
Spread

23.Singe
23.Singe
Chapter 2.5
Boss
2
3
Rating
10.8
Spread
2
3
Rating
10.8
Spread

24.The Siren
24.The Siren
Chapter 3.5
Boss
2
1
Rating
7.6
Spread
2
1
Rating
7.6
Spread

25.Great Gideon
25.Great Gideon
Chapter 2.5
Boss
2
1
Rating
5.1
Spread
2
1
Rating
5.1
Spread

26.The Horny Boys
26.The Horny Boys
Chapter 3.5
Boss
2
0
Rating
3.6
Spread
2
0
Rating
3.6
Spread

27.The Shell
27.The Shell
Chapter 2.5
Boss
2
0
Rating
2.3
Spread
2
0
Rating
2.3
Spread

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Edit Votes

The Hardest Binding of Isaac Bosses

1.The Visage

1.The Visage

0.6

0.6

2.Mega Satan

2.Mega Satan

0.7

0.7

3.Ultra Greedier

3.Ultra Greedier

0.9

0.9

4.Delirium

4.Delirium

8.1

8.1

5.The Pile

5.The Pile

10.1

10.1

6.Mother

6.Mother

8.8

8.8

7.Hush

7.Hush

8.8

8.8

8.The Heretic

8.The Heretic

2

2

9.Clutch

9.Clutch

18.5

18.5

10.Dogma

10.Dogma

7.4

7.4

11.The Lamb

11.The Lamb

12.1

12.1

12.It Lives

12.It Lives

12.3

12.3

13.Ultra Greed

13.Ultra Greed

6

6

14.Tuff Twins

14.Tuff Twins

9.1

9.1

15.Reap Creep

15.Reap Creep

3.5

3.5

16.Satan

16.Satan

2.3

2.3

17.Isaac (Boss)

17.Isaac (Boss)

3.8

3.8

18.Mom

18.Mom

4.7

4.7

19.Mom's Heart

19.Mom's Heart

3.6

3.6

20.The Beast

20.The Beast

9.3